Investigating the effect of heat flux on tetracycline absorption by bio-MOF-11 nanostructure: A molecular dynamics approach DOI Creative Commons

Z. Liu,

Ali Basem, Haydar A.S. Aljaafari

et al.

Case Studies in Thermal Engineering, Journal Year: 2024, Volume and Issue: 60, P. 104756 - 104756

Published: June 27, 2024

Tetracycline is a type of antibiotic that falls under the category antibiotics. Studying absorption process by bio-MOF-11 carrier important for enhancing drug delivery efficiency, optimizing dosage, and increasing bioavailability, ultimately improving treatment outcomes potentially leading to development new therapies. The present study examined effect variable amplitude heat flux (HF) on carriers' ability absorb tetracycline. Various parameters were assessed documented using molecular dynamics simulation LAMMPS software, including mean square displacement, number particles, diffusion coefficient, interaction energy. results show 0.04 W/m2, energy became more negative, decreasing from −1376.35 −1549.35 kcal/mol. Both displacement coefficient increased 72.906 Å2 75.69 28 nm2/ns 79.745 83.28 nm2/ns, respectively. Also, penetrated Tetracycline-Drug in carriers 606, but it decreased 520 with further increase HF 0.08 W/m2. different ways affected adsorption within MOF structure may be cause this change. first improvement penetration can sign improved binding mobility at moderate HFA. In contrast, subsequent decrease higher HFA levels could suggest excessive disrupts mechanism, affecting stability efficiency system.

Language: Английский

Exploring metal-organic frameworks (MOFs) in drug delivery: A concise overview of synthesis approaches, versatile applications, and current challenges DOI

Akash Vikal,

Rashmi Maurya, Preeti Patel

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102443 - 102443

Published: Sept. 21, 2024

Language: Английский

Citations

22
Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics DOI Creative Commons
Dilip Kumar Chandra, Awanish Kumar, Chinmaya Mahapatra

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

Citations

2
Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy DOI
Thomas Scattolin, Giovanni Tonon, Eleonora Botter

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3807 - 3839

Published: Jan. 1, 2024

This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.

Language: Английский

Citations

11
Chitosan-derived mesoporous N-doped carbon catalyst embedded with NiO for highly selective benzyl alcohol oxidation DOI
Marzie Sadat Mirhosseyni, Ghodsi Mohammadi Ziarani, Alireza Badiei

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129093 - 129093

Published: Jan. 5, 2024

Language: Английский

Citations

8
Cyrene™ as a tyrosinase inhibitor and anti-browning agent DOI
Joanna Cytarska, Joanna Szulc, Dominika Kołodziej

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 442, P. 138430 - 138430

Published: Jan. 21, 2024

Language: Английский

Citations

8
Fabrication and characterization of a Bi2O3-modified chitosan@ZIF-8 nanocomposite for enhanced drug loading-releasing efficacy DOI
Zahra Khalili, Negar Motakef Kazemi, Zahra Jafari Azar

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130295 - 130295

Published: Feb. 19, 2024

Language: Английский

Citations

7
Biological Metal–Organic Framework-Embedded MXene Nanocomposite as a Wearable Transducer Patch for Real-Time Monitoring of the Sleep Hormone DOI
Bartholomew Richard,

K. Niyas,

Menon Ankitha

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 9585 - 9597

Published: April 17, 2024

Sleep is an inherent property of human beings, and it mainly associated with the sleep hormone melatonin (MEL). Abnormal levels MEL can lead to disorders like hypertension, stress, dementia, Alzheimer's disease, etc. Therefore, continuous monitoring this great concern. In study, we have developed a sensing platform by combining Nb2CTx MXene nanosheets zinc-based metal–organic framework (Zn-MOF). The MOF was synthesized using zinc ion as metal part l-glutamic acid organic linker. Because linker itself biological molecule, be denoted bio-MOF whole. This novel composite (Zn-MOF-Nb2CTx MXene) offers enhanced electrocatalytic properties, improved electrical conductivity, increased active sites, making well-suitable for electrochemical detection MEL. Notably, inlay nanoflakes onto created synergistic effect that greatly performance detection. sensor made Zn-MOF-Nb2CTx nanocomposite coated on carbon yarn (CY) exhibited wide linear range MEL, spanning from 1 100 μM, limit 215 nM. Importantly, displayed high selectivity against interfering compounds commonly encountered in body fluids. Also, check practical applicability sensor, tried fluids sweat, blood serum, cerebrospinal fluid (CSF) prove its practicability real-time medical scenarios. use CY electrode material opens door potential integration into band-aid make wearable point-of-care device current health sector applications.

Language: Английский

Citations

5
Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship DOI
Parteek Prasher, Rabab Fatima, Mousmee Sharma

et al.

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 386, P. 110747 - 110747

Published: Oct. 9, 2023

Language: Английский

Citations

12
Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment DOI Creative Commons

Xiaowei Xie,

Tianxiang Yue,

Wenting Gu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2483 - 2483

Published: Oct. 17, 2023

Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA severely constrained by low serum stability and cell membrane permeability. Therefore, improving delivery efficiency cancer treatment research hotspot. Recently, mesoporous silica nanoparticles (MSNs) have emerged as bright vehicles nucleic acid drugs. A comprehensive understanding design MSN-based vectors crucial application in therapy. We discuss several surface-functionalized MSNs’ advancements effective this paper. The advantages MSNs loading regarding considerations different shapes, various options surface functionalization, customizable pore sizes are highlighted. recent investigations into strategies that efficiently improve cellular uptake, facilitate endosomal escape, promote cargo dissociation from enhanced intracellular delivery. Also, particular attention was paid to exciting progress made combining RNAi with other therapies therapeutic outcomes.

Language: Английский

Citations

12
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review DOI

Songlin Zhou,

Yutao Qin,

Anle Lei

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: Jan. 30, 2025

There are 275,000 new cases of oral cancer (OC) per year, making it the sixth most common in world. Severe adverse effects, including loss function, deformity, and systemic toxicity, familiar with traditional therapies such as radiation, chemotherapy, surgery; due to their unique properties, nanoparticles (NPs) have emerged a superior alternative over chemo/radiotherapy surgery targeting capability, bioavailability, compatibility, high solubility. Due metallic NPs garnered significant attention OC control. In addition fact that metal may be harmful human cells, reactive chemicals used make them pose same risk, which limits use medicine. Green synthesis (GS) is novel strategy uses biological materials like yeast, bacteria, fungi, plant extracts. Compared more chemical processes, these environmentally benign manageable for living organisms. This article summarizes GS made metals oxides anticancer effects on OC. The method's potential benefits drawbacks advancing NPs' shaping therapy's future were also discussed.

Language: Английский

Citations

0