Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1064 - 1064

Published: June 30, 2021

Soybeans are rich in proteins and lipids have become a staple part of the human diet. Besides their nutritional excellence, they also been shown to contain various functional components, including isoflavones, consequently received increasing attention as food item. Isoflavones structurally similar 17-β-estradiol bind estrogen receptors (ERα ERβ). The estrogenic activity isoflavones ranges from hundredth thousandth that itself. play role regulating effects body, depending on situation. Thus, when is insufficient, perform functions estrogen, excessive, block which binds, thus acting an antagonist. In particular, antagonistic important breast, endometrium, prostate, such suppresses cancer occurrence. Genistein, isoflavone, has cancer-suppressing receptor-positive (ER+) cancers, breast cancer. It function enzymes tyrosine protein kinase, mitogen-activated DNA polymerase II, inhibiting cell proliferation inducing apoptosis. Genistein most biologically active potent isoflavone candidate for prevention. Furthermore, among physiological best known antioxidant activities. S-Equol, metabolite genistein daidzein, strong antioxidative effects; however, ability metabolize daidzein into S-equol varies based racial individual differences. may be effective preventing dementia by phosphorylation Alzheimer's-related tau proteins. reduces allergic responses limiting expression mast IgE receptors, involved responses. addition, prevent treat diseases, cardiovascular metabolic syndromes, osteoporosis, diabetes, brain-related high blood pressure, hyperlipidemia, obesity, inflammation. Further, it positive menstrual irregularity non-menopausal women relieving menopausal symptoms middle-aged women. Recently, soybean consumption steep trend Western countries where intake was previously only 1/20-1/50 Asian countries. this review, I dealt with latest research trends substantial interest biological efficacy humans plants, related mechanisms.

Language: Английский

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Flavonoids as antiobesity agents: A review

Medicinal Research Reviews, Journal Year: 2020, Volume and Issue: 41(1), P. 556 - 585

Published: Oct. 20, 2020

Obesity is a global health problem that affects all age groups in both developing and developed countries. In recent years, the prevalence of overweight obesity has reached pandemic levels, resulting dramatic increase incidence various comorbidities, such as cardiovascular diseases, type 2 diabetes, cancer, consequently leading to massive socioeconomic burdens. Together with lifestyle changes, antiobesity pharmacotherapy gaining momentum an adjunctive treatment. However, available pharmacological approaches have limited use owing either significant adverse effects or low efficacy. Over natural products been important source lead compounds for drug discovery. Among these, flavonoids are associated biological health-promoting activities. this review, we discuss modulatory on their potential mechanisms action. The literature strongly suggests most common demonstrate pronounced effect shown by ability lower body weight, fat mass, plasma triglycerides/cholesterol, vitro vivo models. impact can be observed through different mechanisms: reducing food intake absorption, increasing energy expenditure, modulating lipid metabolism, regulating gut microbiota profile. A better understanding known will enable treat medical condition. Therefore, review focuses putative which may prevent highlights new perspectives future use.

Language: Английский

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Phytochemicals as potential candidates to combat obesity via adipose non-shivering thermogenesis

Pharmacological Research, Journal Year: 2019, Volume and Issue: 147, P. 104393 - 104393

Published: Aug. 8, 2019

Language: Английский

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Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1

Food & Function, Journal Year: 2020, Volume and Issue: 11(3), P. 2418 - 2426

Published: Jan. 1, 2020

Genistein may regulate lipid metabolism in adipose tissue of obese mice by regulating the expression miR-222 and its target genes, BTG2 adipor1.

Language: Английский

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Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome

Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 5863 - 5863

Published: Sept. 27, 2021

Isoflavones are polyphenols primarily contained in soybean. As phytoestrogens, isoflavones exert beneficial effects on various chronic diseases. Metabolic syndrome increases the risk of death due to arteriosclerosis individuals with pathological conditions, including obesity, hypertension, hyperglycemia, and dyslipidemia. Although health benefits soybean-derived widely known, their pathogenesis metabolic incompletely understood. This review aims describe association between isoflavone intake development. We reviewed studies soy isoflavones, particularly daidzein genistein, syndrome, using PubMed, ScienceDirect, Web Science. characteristics those contributing multiple conditions. Furthermore, we summarize genistein reported human epidemiological experiments vitro vivo models. In particular, emphasize role syndrome-induced cardiovascular conclusion, this focuses potential prevent by influencing onset dyslipidemia, discusses anti-inflammatory isoflavones.

Language: Английский

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Natural bioactive constituents from herbs and nutraceuticals promote browning of white adipose tissue

Pharmacological Research, Journal Year: 2022, Volume and Issue: 178, P. 106175 - 106175

Published: March 10, 2022

Language: Английский

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Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3676 - 3676

Published: Feb. 12, 2023

Cancer is one of the leading causes death worldwide. Chemotherapy and radiation therapy are currently providing basis for cancer therapies, although both associated with significant side effects. Thus, prevention through dietary modifications has been receiving growing interest. The potential selected flavonoids in reducing carcinogen-induced reactive oxygen species (ROS) DNA damage activation nuclear factor erythroid 2 p45 (NF-E2)-related (Nrf2)/antioxidant response element (ARE) pathway was studied vitro. Dose-dependent effects pre-incubated on pro-carcinogen 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKAc)-induced ROS human bronchial epithelial cells were comparison to non-flavonoids. most effective assessed Nrf2/ARE pathway. Genistein, procyanidin B2 (PCB2), quercetin significantly suppressed NNKAc-induced damage. Quercetin upregulated phosphorylated protein kinase B/Akt. PCB2 Nrf2 Akt phosphorylation. Genistein phospho-Nrf2 translocation catalase activity. In summary, genistein reduced Nrf2. Further studies required understand role regulation relation carcinogenesis.

Language: Английский

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Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Plants, Journal Year: 2023, Volume and Issue: 12(12), P. 2278 - 2278

Published: June 12, 2023

There are various herbicides which were used in the agriculture industry. Atrazine (ATZ) is a chlorinated triazine herbicide that consists of ring structure, known as ring, along with chlorine atom and five nitrogen atoms. ATZ water-soluble herbicide, makes it capable easily infiltrating into majority aquatic ecosystems. reports toxic effects on different systems body but, unfortunately, these scientific documented animals. The was reported to enter through routes. toxicity can cause deleterious respiratory, reproductive, endocrine, central nervous system, gastrointestinal, urinary human body. Alarmingly, few studies industrial workers showed exposure leading cancer. We embarked present review discuss mechanism action for there no specific antidote or drug. Evidence-based published literature effective use natural products such lycopene, curcumin, Panax ginseng, Spirulina platensis, Fucoidans, vitamin C, soyabeans, quercetin, L-carnitine, Telfairia occidentalis, E, Garcinia kola, melatonin, selenium, Isatis indigotica, polyphenols, Acacia nilotica, Zingiber officinale discussed detail. In absence any particular allopathic drug, may open doors future drug design involving their active compounds.

Language: Английский

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In silico and in vitro analysis of PPAR – α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat

Computers in Biology and Medicine, Journal Year: 2022, Volume and Issue: 147, P. 105796 - 105796

Published: June 28, 2022

Language: Английский

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Exploring the mechanism of Pueraria lobata (Willd.) Ohwi in the regulation of obesity

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118703 - 118703

Published: Aug. 16, 2024

Language: Английский

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