The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1224 - 1224

Published: June 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Language: Английский

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Flavonoids—Natural Gifts to Promote Health and Longevity

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2176 - 2176

Published: Feb. 16, 2022

The aging of mammals is accompanied by the progressive atrophy tissues and organs accumulation random damage to macromolecular DNA, protein, lipids. Flavonoids have excellent antioxidant, anti-inflammatory, neuroprotective effects. Recent studies shown that flavonoids can delay prolong a healthy lifespan eliminating senescent cells, inhibiting senescence-related secretion phenotypes (SASPs), maintaining metabolic homeostasis. However, only few systematic described in clinical treatment for anti-aging, which needs be explored further. This review first highlights association between damage. Then, we discuss advances role flavonoid molecules prolonging health span organisms. study may provide crucial information drug design developmental applications based on flavonoids.

Language: Английский

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The Interaction between Flavonoids and Intestinal Microbes: A Review

Foods, Journal Year: 2023, Volume and Issue: 12(2), P. 320 - 320

Published: Jan. 9, 2023

In recent years, research on the interaction between flavonoids and intestinal microbes have prompted a rash of food science, nutriology biomedicine, complying with future trends. The gut microbiota plays an essential role in maintenance homeostasis human health, but once flora dysregulation occurs, it may contribute to various diseases. Flavonoids shown variety physiological activities, are metabolized or biotransformed by microbiota, thereby producing new metabolites that promote health modulating composition structure flora. Herein, this review demonstrates key notion as well dysbiosis, aiming provide comprehensive understanding about how regulate diseases microbiota. Emphasis is placed microbiota-flavonoid bidirectional affects metabolic fate their metabolites, influencing mechanism, biotransformation, bioavailability bioactivity. Potentially focusing abundance diversity such bile acids, we discuss influence mechanism protecting barrier function immune system. Additionally, crucial regulating We explain underlying regulation several typical including gastrointestinal diseases, obesity, diabetes cancer, theoretical basis guideline for promotion treatment

Language: Английский

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Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations

Food Research International, Journal Year: 2022, Volume and Issue: 157, P. 111442 - 111442

Published: May 30, 2022

Language: Английский

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Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8344 - 8344

Published: July 28, 2022

Diets high in bioactive compounds, such as polyphenols, have been used to mitigate metabolic syndrome (MetS). Polyphenols are a large group of naturally occurring classified into two main classes: non-flavonoids and flavonoids. Flavonoids distributed foods, fruits, vegetables, tea, red wine, cocoa. Studies already demonstrated the benefits flavonoids on cardiovascular nervous systems, well cancer cells. The present review summarizes results clinical studies that evaluated effects components MetS associated complications when offered supplements over long term. show can significantly modulate several parameters, lipid profile, blood pressure, glucose. Only theaflavin catechin were unable affect parameters. Moreover, only body weight mass index unaltered. Thus, evidence presented this systematic offers bases support flavonoid supplementation, held for at least 3 weeks, strategy improve parameters and, consequently, reduce risk diseases with MetS. This fact becomes stronger due rare side reported

Language: Английский

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Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 21, 2023

Diet may influence biological aging and the discrepancy (∆age) between a subject's age (BA) chronological (CA). We aimed to investigate correlation of dietary flavonoids with ∆age organs (heart, kidney, liver) whole body.A total 3193 United States adults were extracted from National Health Nutrition Examination Survey (NHANES) in 2007-2008 2017-2018. Dietary intake was assessed using 24-h recall method. Multiple linear regression analysis performed evaluate association body. BA computed based on circulating biomarkers, resulting tested as an outcome analysis.The body, heart, liver inversely associated higher (the body β = - 0.58, cardiovascular 0.96, 3.19) after adjustment for variables. However, positively related renal (β 0.40) participants chronic kidney disease (CKD). Associations influenced by population characteristics, such age, health behavior, or diseases. Anthocyanidins, isoflavones flavones had strongest inverse associations among all subclasses.Flavonoids contributes delaying process, especially organ, which be beneficial reducing long-term risk disease.

Language: Английский

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Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

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A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2023, Volume and Issue: 22(3), P. 1763 - 1793

Published: March 4, 2023

Abstract Citrus is an important source of flavonoids in our daily diet. have antioxidant, anticancer, anti‐inflammatory, and cardiovascular disease prevention functions. Studies shown that some pharmaceutical values may be related to their binding bitter taste receptors, thus activating downstream signal transduction pathways; however, the underlying mechanism has not been systematically elucidated. In this paper, biosynthesis pathway absorption metabolism citrus were briefly reviewed, relationship between flavonoid structure intensity was investigated. addition, pharmacological effects activation receptors combating various diseases discussed. This review provides basis for targeted design structures make them more biologically active attractive as powerful drugs effective treatment chronic such obesity, asthma, neurological diseases.

Language: Английский

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Clinical development and informatics analysis of natural and semi-synthetic flavonoid drugs: A critical review

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 63, P. 269 - 284

Published: Nov. 8, 2023

Flavonoids are one of the most important metabolites with vast structural diversity and a plethora potential pharmacological applications, which have drawn considerable attention in laboratory. Nevertheless, it remains uncertain how many candidates were progressed to clinical application. Review: We carried out critical review natural semi-synthetic flavonoid drugs undergoing different phases worldwide by applying an adequate search method conducted brief cheminformatic bioinformatic analysis. It was expected that obtained results might narrow screening scope reduce cost drug research development. Key scientific Concepts To our knowledge, this is systematic summarization flavonoid-based date. found total 19 been approved for market, these, flavonoids accounted 52.6%. Besides, 36 or suspended phases, account 44.4%. Thus, remain best option finding novel agents/active templates, when investigated conjunction synthetic chemicals biologicals, they offer discover structures can lead effective agents against variety human diseases. Additionally, marketed successful cardiovascular treatment, related more than 30% drugs. However, use as antineoplastic immunomodulating not likely approximately 50% stage. Interestingly, covered broader range chemical spaces based on size, polarity, three-dimensional structure compared candidates. In addition, glycosides poor oral bioavailability 36.8% drugs, thus, could be thoroughly investigated.

Language: Английский

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Inflammation and Obesity: The Pharmacological Role of Flavonoids in the Zebrafish Model

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2899 - 2899

Published: Feb. 2, 2023

A Mediterranean-style diet is highly encouraged thanks to its healthy food pattern, which includes valuable nutraceuticals such as polyphenols. Among these, flavonoids are associated with relevant biological properties through they prevent or fight the onset of several human pathologies. Globally, enhanced incidence overweight and obese people has caused a dramatic increase in comorbidities, raising need provide better therapies. Therefore, development sophisticated animal models metabolic dysregulation allowed for deepening knowledge on this subject. Recent advances using zebrafish (Danio rerio) model disease have yielded fundamental insights into potential anti-obesity effects flavonoids. Chronic low-grade inflammation immune system activation seem characterize pathogenesis obesity; thus, their reduction might improve lipid profile patients illnesses. In review, we highlight beneficial role obesity related diseases linked anti-inflammatory properties. light summarized studies, suggest that therapies could place prevention treatment disorders.

Language: Английский

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