Endocrine Reviews,
Journal Year:
2022,
Volume and Issue:
44(3), P. 357 - 378
Published: Nov. 8, 2022
Abstract
Hypomagnesemia
is
10-fold
more
common
in
individuals
with
type
2
diabetes
(T2D)
than
the
healthy
population.
Factors
that
are
involved
this
high
prevalence
low
Mg2+
intake,
gut
microbiome
composition,
medication
use,
and
presumably
genetics.
associated
insulin
resistance,
which
subsequently
increases
risk
to
develop
T2D
or
deteriorates
glycemic
control
existing
diabetes.
supplementation
decreases
T2D-associated
features
like
dyslipidemia
inflammation,
important
factors
for
cardiovascular
disease
(CVD).
Epidemiological
studies
have
shown
an
inverse
association
between
serum
of
developing
heart
failure
(HF),
atrial
fibrillation
(AF),
microvascular
T2D.
The
potential
protective
effect
on
HF
AF
may
be
explained
by
reduced
oxidative
stress,
fibrosis,
electrical
remodeling
heart.
In
disease,
reduces
detrimental
effects
hyperglycemia
improves
endothelial
dysfunction;
however,
clinical
assessing
long-term
CVD
incidents
lacking,
gaps
remain
how
reduce
Despite
hypomagnesemia
people
T2D,
routine
screening
deficiency
provide
when
needed
not
implemented
care
as
sufficient
evidence
lacking.
conclusion,
both
cause,
probably
through
molecular
mechanisms
leading
consequence
prospectively
development
HF,
AF,
complications.
Whether
beneficial,
remains
determined.
Frontiers in Psychiatry,
Journal Year:
2019,
Volume and Issue:
10
Published: April 9, 2019
The
significant
biochemical
and
physiological
effects
of
psychological
stress
are
beginning
to
be
recognized
as
exacerbating
common
diseases,
including
osteoporosis.
This
review
discusses
the
current
evidence
for
stress-associated
mental
health
disorders
risk
factors
osteoporosis,
mechanisms
that
may
link
these
conditions,
potential
implications
treatment.
Traditional,
alternative,
adjunctive
therapies
discussed.
is
not
intended
provide
therapeutic
recommendations,
but,
rather,
goal
this
delineate
interactions
osteoporosis
highlight
multi-system
pharmacological
interventions.
Review
literature
identifies
several
potentially
overlapping
mechanistic
pathways
interest
(e.g.,
glucocorticoid
signaling,
insulin-like
growth
factor
serotonin
signaling)
further
basic
clinical
research.
Current
also
supports
cross-effects
therapeutics
disorders.
While
studies
examining
a
direct
between
chronic
limited,
reviewed
herein
suggest
multi-factorial,
personalized
approach
should
considered
improved
patient
outcomes
in
populations
experiencing
stress,
particularly
those
at
high-risk
development
Beni-Suef University Journal of Basic and Applied Sciences,
Journal Year:
2022,
Volume and Issue:
11(1)
Published: March 7, 2022
The
novel
coronavirus
has
embarked
on
a
global
pandemic
and
severe
mortality
with
limited
access
for
its
treatments
medications.
For
the
lack
of
time,
research,
enough
efficacy,
most
vaccines
are
underdeveloped
or
unreachable
to
society.
However,
many
recent
studies
suggest
various
alternative,
complementary
remedies
COVID-19,
which
functional
foods.
This
review
provides
an
overview
how
foods
can
play
great
role
through
modulating
host
immune
system,
generating
antiviral
activities,
synthesizing
biologically
active
agents
effective
against
coronavirus.
Medicina,
Journal Year:
2023,
Volume and Issue:
59(7), P. 1190 - 1190
Published: June 24, 2023
Hypermagnesemia
is
a
relatively
uncommon
but
potentially
life-threatening
electrolyte
disturbance
characterized
by
elevated
magnesium
concentrations
in
the
blood.
Magnesium
crucial
mineral
involved
various
physiological
functions,
such
as
neuromuscular
conduction,
cardiac
excitability,
vasomotor
tone,
insulin
metabolism,
and
muscular
contraction.
Hypomagnesemia
prevalent
that
can
lead
to
several
neuromuscular,
cardiac,
or
nervous
system
disorders.
has
been
associated
with
adverse
clinical
outcomes,
particularly
hospitalized
patients.
Prompt
identification
management
of
hypermagnesemia
are
prevent
complications,
respiratory
cardiovascular
negative
dysfunction,
coma.
Preventing
crucial,
high-risk
populations,
patients
impaired
renal
function
those
receiving
magnesium-containing
medications
supplements.
Clinical
involves
discontinuing
therapies,
intravenous
fluid
therapy,
dialysis
severe
cases.
Furthermore,
healthcare
providers
should
monitor
serum
concentration
at
risk
promptly
intervene
if
exceeds
normal
range.
The
kidney
reabsorption
is
essential
for
maintaining
magnesium
homeostasis.
This
study
aims
to
explore
the
relationship
between
reabsorption-related
depletion
score
(MDS)
and
occurrence
of
cardiovascular
disease
(CVD)
prognosis
in
diabetic
(DKD)
patients.
We
included
3199
DKD
patients
from
National
Health
Nutrition
Examination
Survey
(NHANES)
database,
including
1072
CVD
Weighted
logistic
regression
analysis
was
used
MDS
CVD.
COX
proportional
hazards
mortality.
Stratified
further
validate.
Finally,
we
assessed
predictive
accuracy
on
survival
outcomes
using
time-dependent
receiver
operating
characteristic
(ROC)
curve
analysis.
Survey-weighted
multiple
revealed
that
≥
3,
incidence
increased
by
371%.
During
follow-up
period
(median
87
months),
1373
all-cause
deaths
(497
deaths)
were
recorded.
In
patients,
mortality
78%
(P
<
0.001)
cardiac
76%
=
0.08).
Consistent
results
also
shown
when
stratified
age,
sex,
race,
marital
status,
intake.
area
under
(AUC)
values
predicting
1-,2-,3-,4-,
5-year
0.86,
0.66,
0.59,
0.57,
0.55,
0.9,
0.67,
0.62,
0.58,
0.56
MDS,
reabsorption-related,
positively
correlated
with
longitudinal
Heliyon,
Journal Year:
2020,
Volume and Issue:
6(11), P. e05390 - e05390
Published: Nov. 1, 2020
Magnesium
is
essential
in
plants
where
it
associated
with
chlorophyll
pigments
and
serves
as
a
cofactor
of
enzymes
implicated
photosynthesis
metabolism.
It
an
nutrient
for
animals,
involved
hundreds
metabolic
reaction
crucial
the
biological
activity
ATP.
Not
surprisingly,
magnesium
deficiency
detrimental
health
animals.
In
humans,
subclinical
common
generates
chronic
inflammation,
which
denominator
wide
range
mental
physical
problems
from
diseases
to
cognitive
impairment,
osteopenia
sarcopenia
depression.
ascertained
that
content
fruits
vegetables
dropped
last
fifty
years,
about
80%
this
metal
lost
during
food
processing.
As
consequence,
large
percentage
people
all
over
world
does
not
meet
minimum
daily
requirement.
scoping
review,
we
summarize
how
agronomic
environmental
factors,
including
global
warming,
affect
availability
soil
and,
consequently,
chain,
aim
attracting
interest
botanists,
agronomists,
animal
human
nutritionists
physicians
work
on
strategy
grants
adequate
intake
everybody.
Nutrients,
Journal Year:
2021,
Volume and Issue:
14(1), P. 74 - 74
Published: Dec. 24, 2021
Bone
is
a
nutritionally
modulated
tissue.
Given
this
background,
aim
of
review
to
evaluate
the
latest
data
regarding
ideal
dietary
approach
in
order
reduce
bone
mineral
density
loss
and
construct
food
pyramid
that
allows
osteopenia/osteoporosis
patients
easily
figure
out
what
eat.
The
shows
carbohydrates
should
be
consumed
every
day
(3
portions
whole
grains),
together
with
fruits
vegetables
(5
portions;
orange-colored
green
leafy
are
preferred),
light
yogurt
(125
mL),
skim
milk
(200
mL,)
extra
virgin
olive
oil
(almost
20
mg/day),
calcium
water
1
l/day);
weekly
include
fish
(4
portions),
white
meat
legumes
(2
eggs
cheeses
red
or
processed
meats
(once/week).
At
top
pyramid,
there
two
pennants:
one
means
subjects
need
some
personalized
supplementation
(if
daily
requirements
cannot
satisfied
through
diet,
calcium,
vitamin
D,
boron,
omega
3,
isoflavones
could
an
effective
strategy
great
benefit/cost
ratio),
foods
banned
(salt,
sugar,
inorganic
phosphate
additives).
Finally,
three
four
times
per
week
30–40
min
aerobic
resistance
exercises
must
performed.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 25, 2024
Neurodegenerative
diseases,
which
are
characterized
by
progressive
neuronal
loss
and
cognitive
decline,
a
significant
concern
for
the
aging
population.
Neuroinflammation,
shared
characteristic
of
these
is
implicated
in
their
pathogenesis.
This
article
briefly
summarizes
role
magnesium,
an
essential
mineral
involved
numerous
enzymatic
reactions
critical
bioactivity,
context
neuroinflammation
decline.
The
potential
neuroprotective
effects
including
mechanisms
neuroprotection
magnesium
through
maintaining
ion
homeostasis,
reducing
inflammation,
preventing
excitotoxicity,
also
described.
Additionally,
we
discuss
impact
inadequate
on
its
as
therapeutic
agent
attenuating
decline
to
improve
neurodegenerative
conditions.
