Health benefits of polyphenols: A concise review

Journal of Food Biochemistry, Journal Year: 2022, Volume and Issue: 46(10)

Published: June 13, 2022

Plants produce polyphenols, which are considered highly essential functional foods in our diet. They classified into several groups according to their diverse chemical structures. Flavanoids, lignans, stilbenes, and phenolic acids the four main families of polyphenols. Several vivo vitro research have been conducted so far evaluate health consequences. Polyphenols serve a vital function protection organism from external stimuli eliminating reactive oxygen species (ROS), instigators illnesses. present tea, chocolate, fruits, vegetables with potential positively influence human health. For instance, cocoa flavan-3-ols associated decreased risk myocardial infarction, stroke, diabetes. diet also help improve lipid profiles, blood pressure, insulin resistance, systemic inflammation. Quercetin, flavonoid, resveratrol, stilbene, linked improved cardiovascular Dietary polyphenols elicit therapeutic effects might be attributed, at least part, bidirectional association gut microbiome. This is because known affect microbiome composition ways that lead better Specifically, converts bioactive compounds effects. In this review, antioxidant, cytotoxicity, anti-inflammatory, antihypertensive, anti-diabetic actions described based on findings experimental trials. Practical applications The non-communicable diseases (NCDs) burden has increasing worldwide due sedentary lifestyle other factors such as smoking, junk food, etc. Scientific literature evidence supports use plant-based food agents could alleviate NCD's burden. Thus, consuming polyphenolic natural sources an effective solution mitigate NCDs concerns. It discussed how antioxidants medicinal plants prevent or repair damage caused by free radicals, oxidative stress.

Language: Английский

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The mutual interplay of gut microbiota, diet and human disease

FEBS Journal, Journal Year: 2020, Volume and Issue: 287(5), P. 833 - 855

Published: Jan. 19, 2020

The intestinal milieu harbours the gut microbiota, consisting of a complex community bacteria, archaea, fungi, viruses and protozoans that bring to host organism an endowment cells genes more numerous than its own. In last 10 years, mounting evidence has highlighted prominent influence mutualistic bacterial communities on human health. Microbial colonization occurs alongside with immune system development plays role in physiology. microbiota does not undergo significant fluctuations throughout adult life. However, infections, antibiotic treatment, lifestyle, surgery diet might profoundly affect it. Gut dysbiosis, defined as marked alterations amount function microorganisms, is correlated aetiology chronic noncommunicable diseases, ranging from cardiovascular, neurologic, respiratory metabolic illnesses cancer. this review, we focus interplay among provide perspective their unique metabolites pathogenesis and/or progression various disorders. We discuss interventions based microbiome studies, faecal transplantation, probiotics prebiotics, introduce concept correcting dysbiosis can ameliorate disease symptoms, thus offering new approach towards treatment.

Language: Английский

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Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 206 - 206

Published: Jan. 12, 2021

Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, they most abundant antioxidant human diet. Studies suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes may contribute prevention several chronic disorders like diabetes, obesity, hypertension, colon cancer. have structural diversity which impacts their bioavailability as accumulate large intestine extensively metabolized through gut microbiota (GM). Intestinal transforms into metabolites make them bioactive. Interestingly, not only GM act on metabolize but also modulate composition GM. Thus, change from pathogenic beneficial ones health associated diseases. However, overcome low PPs, various approaches been developed improve solubility transportation gut. In this review, we present evidence supporting changes occur after reactions (curcumin, quercetin, catechins) effect leads improving overall helping disorders.

Language: Английский

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Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Nutrients, Journal Year: 2020, Volume and Issue: 12(9), P. 2499 - 2499

Published: Aug. 19, 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries traditional Asian medicine, and nowadays it is widely food as dietary spice worldwide. It received considerable attention its pharmacological activities, which appear to act primarily through anti-inflammatory antioxidant mechanisms. For this reason, proposed tool management many diseases, among are gastrointestinal neurological diabetes, several types cancer. However, pharmacology curcumin remains be elucidated; indeed, discrepancy exists between well-documented vitro vivo activities poor bioavailability chemical instability that should limit any therapeutic effect. Recently, hypothesized could exert direct regulative effects tract, where high concentrations have detected after oral administration. Consequently, might directly exerts regulatory on gut microbiota, thus explaining paradox low systemic wide activities. well known microbiota important roles human physiology, composition can influenced by multitude environmental lifestyle factors. Accordingly, perturbations microbiome profile or dysbiosis key role disease progression. Interestingly, metabolites shown influence microbiota. worth noting from interaction two different phenomena arise: regulation intestinal microflora biotransformation both them potentially crucial activity. This review summarizes most recent studies topic, highlighting strong connection with final aim adding new insight into potential mechanisms effects.

Language: Английский

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Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(10), P. 1715 - 1715

Published: Oct. 17, 2021

Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to use this compound. Poor absorption, fast metabolism, rapid systemic clearance are most important factors contributing low curcumin levels in plasma tissues. Accordingly, overcome these issues, numerous strategies have been proposed investigated article. Due advances field, we describe here promising for increasing including adjuvant, complexed/encapsulated curcumin, specific formulations, nanoparticles. We analyze current strategies, already available market, advanced technologies that can offer future perspective effective formulations. focus attention on effectiveness curcumin-based formulations clinical trials, providing comprehensive summary. Clinical trial results, employing various methods showed improved bioavailability corresponds increased therapeutic efficacy. Furthermore, field nanoparticles hold great promise developing complexes as agents. Summarizing, suitable polyphenol will ensure possibility using curcumin-derived practice preventive disease-modifying therapeutics.

Language: Английский

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Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

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Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 10, 2023

The yellow polyphenolic pigment known as curcumin, originating from the rhizome of turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, well cooking and food coloring. Recently, biological activities curcumin have thoroughly investigated. studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion usage within processing industries its effect health support disease prevention. Curcumin’s bioavailability, bio-efficacy, bio-safety characteristics, side effects quality standards, are also discussed. Finally, curcumin’s multifaceted uses, appeal enhancement, agro-industrial techniques counteracting instability low nanotechnology drug delivery systems increase prospective clinical use tactics all

Language: Английский

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Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice

Food Research International, Journal Year: 2021, Volume and Issue: 143, P. 110270 - 110270

Published: March 10, 2021

Language: Английский

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Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116034 - 116034

Published: Dec. 22, 2023

The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, depression. Most these benefits due to their anti-inflammatory antioxidant properties. Curcumin consumption leads decreased bioavailability, resulting limited absorption, quick metabolism, excretion, hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with a complex. When other enhancing agents, has wide spectrum benefits. This review evaluates therapeutic potential specific emphasis on approach based molecular signaling pathways. study investigated influence progression cancer, inflammation, many health-related mechanisms, cell proliferation, apoptosis, metastasis. significant for prevention treatment various diseases. modulates several biochemical pathways targets involved cancer growth. Despite tissue accumulation administered orally, proven useful. provides in-depth analysis curcumin's applications, pathway-based approach, precision medicine human health.

Language: Английский

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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

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