Amelioration of Alcoholic Hepatic Steatosis in a Rat Model via Consumption of Poly-γ-Glutamic Acid-Enriched Fermented Protaetia brevitarsis Larvae Using Bacillus subtilis DOI Creative Commons
So-Yeon Sim, Hyun‐Dong Cho, Sae-Byuk Lee

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 861 - 861

Published: March 3, 2025

Alcoholic hepatic steatosis (AHS) is a common early-stage symptom of liver disease caused by alcohol consumption. Accordingly, several aspects AHS have been studied as potential preventive and therapeutic targets. In this study, novel strategy was employed to inhibit fatty accumulation counteract through the consumption microorganism-fermented Protaetia brevitarsis larvae (FPBs). By using an rat model, we assessed efficacy FPB examining lipid profile liver/serum function tests evaluate metabolism modulation. After administration, profile-including high-density lipoprotein, total cholesterol, triglycerides-and histopathological characteristics exhibited improvement in animal model. Interestingly, amelioration via FPBs administration potentially associated with poly-γ-glutamic acid (PγG), which produced Bacillus species during fermentation. These findings support formulation natural remedies for non-clinical studies, suggesting that PγG-enriched are valuable ingredient functional foods, providing ameliorative effect on AHS.

Language: Английский

Ten things to know about ten cardiovascular disease risk factors DOI Creative Commons
Harold Bays, Pam R. Taub,

Elizabeth Epstein

et al.

American Journal of Preventive Cardiology, Journal Year: 2021, Volume and Issue: 5, P. 100149 - 100149

Published: Jan. 23, 2021

Given rapid advancements in medical science, it is often challenging for the busy clinician to remain up-to-date on fundamental and multifaceted aspects of preventive cardiology maintain awareness latest guidelines applicable cardiovascular disease (CVD) risk factors. The "American Society Preventive Cardiology (ASPC) Top Ten CVD Risk Factors 2021 Update" a summary document (updated yearly) regarding This "ASPC reflects perspective section authors ten things know about sentinel It also includes quick access references (applicable select reviews) each factor section. factors include unhealthful nutrition, physical inactivity, dyslipidemia, hyperglycemia, high blood pressure, obesity, considerations populations (older age, race/ethnicity, sex differences), thrombosis/smoking, kidney dysfunction genetics/familial hypercholesterolemia. For individual patient, other may be relevant, beyond discussed here. However, intent provide succinct overview common cardiology.

Language: Английский

Citations

173

Microbiota and Lifestyle: A Special Focus on Diet DOI Open Access

Noemí Redondo-Useros,

Esther Nova, Natalia González-Zancada

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1776 - 1776

Published: June 15, 2020

It is widely known that a good balance and healthy function for bacteria groups in the colon are necessary to maintain homeostasis preserve health. However, lack of consensus on what defines gut microbiota multitude factors influence human composition complicate development appropriate dietary recommendations our microbiota. Furthermore, varied response intake probiotics prebiotics observed adults suggests existence potential inter- intra-individual factors, which might account changes greater extent than diet. The changing habits worldwide involving consumption processed foods containing artificial ingredients, such as sweeteners; coincident rise emotional disorders; worsening other lifestyle habits, smoking drug consumption, sleep, can together contribute dysbiosis health impairment, well chronic diseases. This review summarizes current literature effects specific ingredients (probiotics, prebiotics, alcohol, refined sugars sweeteners, fats) involved, dramatically increasing nowadays.

Language: Английский

Citations

146

Ten things to know about ten cardiovascular disease risk factors – 2022 DOI Creative Commons
Harold Bays, Anandita Agarwala, Charles German

et al.

American Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 10, P. 100342 - 100342

Published: April 6, 2022

The American Society for Preventive Cardiology (ASPC) "Ten things to know about ten cardiovascular disease risk factors - 2022" is a summary document regarding (CVD) factors. This 2022 update provides tables of 10 CVD and builds upon the foundation prior annual versions factors" published since 2020. version perspective ASPC members includes updated sentinel references (i.e., applicable guidelines select reviews) each factor section. include unhealthful dietary intake, physical inactivity, dyslipidemia, pre-diabetes/diabetes, high blood pressure, obesity, considerations populations (older age, race/ethnicity, sex differences), thrombosis (with smoking as potential contributor thrombosis), kidney dysfunction genetics/familial hypercholesterolemia. Other may be relevant, beyond discussed here. However, it intent provide tabular overview most common preventive cardiology ready access reviews.

Language: Английский

Citations

82

Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition DOI Creative Commons
Siwen Wang, Yanping Li, Yiyang Yue

et al.

JAMA Internal Medicine, Journal Year: 2023, Volume and Issue: 183(3), P. 232 - 232

Published: Feb. 6, 2023

Few modifiable risk factors for post-COVID-19 condition (PCC) have been identified.To investigate the association between healthy lifestyle prior to SARS-CoV-2 infection and of PCC.In this prospective cohort study, 32 249 women in Nurses' Health Study II reported preinfection habits 2015 2017. Healthy included body mass index (BMI, 18.5-24.9; calculated as weight kilograms divided by height meters squared), never smoking, at least 150 minutes per week moderate vigorous physical activity, alcohol intake (5 15 g/d), high diet quality (upper 40% Alternate Eating Index-2010 score), adequate sleep (7 9 h/d).SARS-CoV-2 (confirmed test) PCC (at 4 weeks symptoms) were self-reported on 7 periodic surveys administered from April 2020 November 2021. Among participants with infection, relative (RR) number (0 6) was estimated using Poisson regression adjusting demographic comorbidities.A total 1981 a positive test over 19 months follow-up documented. those participants, mean age 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) White; 42.8% 848) active health care workers. these, 871 (44.0%) developed PCC. associated lower dose-dependent manner. Compared without any factors, 5 6 had 49% (RR, 0.51; 95% CI, 0.33-0.78) In model mutually adjusted all BMI independently 18.5-24.9 vs others, RR, 0.85; 0.73-1.00, P .046; sleep, 7-9 h/d 0.83; 0.72-0.95, .008). If these associations causal, 36.0% cases would prevented if (population attributable percentage, 36.0%; 14.1%-52.7%). Results comparable when defined symptoms 2-month duration or having ongoing time assessment.In pre-infection substantially Future research should whether interventions may reduce developing mitigate among individuals possibly other postinfection syndromes.

Language: Английский

Citations

61

Effect of moderate alcohol intake on blood apolipoproteins concentrations: A meta-analysis of human intervention studies DOI Creative Commons

Anila Khatiwada,

Sine Højlund Christensen,

Ajay Rawal

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103854 - 103854

Published: Jan. 1, 2025

Aims: This study assessed the effect of alcohol intake (up to 40 g/d) on blood apolipoproteins (APOs) concentration in human intervention studies.Additionally, it evaluates whether APOs differs depending sex. Data synthesis:The literature search was performed PubMed, Cochrane, Embase, and Web Science databases.The Cochrane risk bias tool applied.A total 5559 articles were identified, yielding 80 for full-text screening.Twenty-five included data extraction.Compared no intake, up a dose g/d showed an increase Apolipoprotein A-I levels (ApoA-I) [mean difference (MD): 7.77 mg/dl, 95 % confidence interval (CI): 4.95 10.59 mg/dl] A-II (ApoA-II) [MD: 1.61 CI: 0.33 2.90 mg/dl], but significant change B (ApoB) -0.06 -3.38 3.27 mg/dl].Males increase, while females nonsignificant ApoA-I 9.70 6.16 13.28 mg/dl vs MD: 7.31 -0.67 15.30 mg/dl].The results had less certainty as most studies at high bias. Conclusion:Alcohol consumption increases ApoA-II levels.Further research is required ApoB.Considerations should be given when applying this practice.Highquality clinical trials with large sample sizes longer periods are required, focusing including female participants.

Language: Английский

Citations

1

Association of non-highdensity lipoprotein cholesterol to highdensity lipoprotein cholesterol ratio (NHHR) and subsequent hypertension and heart diseases: findings from the CHARLS cohort DOI Creative Commons
Feng Zhang, Zhuqing Li, Meng Wang

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 21, 2025

Abstract Purpose NHHR, the ratio of non-high-density lipoprotein cholesterol to high-density cholesterol, is a novel lipid marker associated with risk heart diseases and various health conditions. However, there limited evidence regarding relationship between NHHR onset hypertension diseases. The aim this study was investigate association new-onset among Chinese middle-aged older general population. Methods This prospective cohort utilized data from nationally representative sample residents aged 45 older, sourced China Health Retirement Longitudinal Study (CHARLS). primary outcomes were To diseases, multivariate logistic regression models restricted cubic spline (RCS) method employed. Additionally, mediating effects on assessed using bootstrap method. Results A total 5349 participants included in final analysis three groups identified, including low-stable, medium-stable, high-stable NHHR. By 2020, 1,631 (30.5%) had been newly diagnosed hypertension, while 1233 (23.1%) developed Compared those low-stable individuals other two showed significantly increased developing findings remained consistent across sensitivity analyses. According RCS analysis, partial U-shaped existed (P for nonlinear < 0.001). Furthermore, found partially mediate Conclusion closely an In addition, mediated development by promoting progression. prevention treatment managing both levels blood pressure crucial.

Language: Английский

Citations

1

Short-Term Changes in Behaviors Resulting from COVID-19-Related Social Isolation and Their Influences on Mental Health in Ghana DOI Creative Commons
Nestor Asiamah, Frank Frimpong Opuni,

Edwin Mends-Brew

et al.

Community Mental Health Journal, Journal Year: 2020, Volume and Issue: 57(1), P. 79 - 92

Published: Oct. 8, 2020

This study assessed the behavioral outcomes of Coronavirus 2019 (COVID-19) social distancing protocols and their influences on mental health. An online survey hosted by Survey Monkey was utilized to collect data from residents three Ghanaian cities Accra, Kumasi Tamale. A total 621 surveys were analyzed, with a sensitivity analysis select covariates for regression model. The average age participants about 36 years. Findings indicate that reduced physical activity time change in sexual smoking frequency are some short-term changes behavior resulting isolation during lockdown. increase sedentary had negative influence For most part, behaviors associated lower health scores. implied COVID-19 measures should be implemented alongside public education discouraging unhealthy behaviors.

Language: Английский

Citations

54

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential DOI Creative Commons
Ravinder Naik Dharavath,

Celeste Pina‐Leblanc,

Victor M. Tang

et al.

Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17

Published: Oct. 20, 2023

Alcohol is one of the most widely used substances. use accounts for 5.1% global disease burden, contributes substantially to societal and economic costs, leads approximately 3 million deaths yearly. disorder (AUD) includes various drinking behavior patterns that lead short-term or long-lasting effects on health. Ethanol, main psychoactive molecule acting in alcoholic beverages, directly impacts GABAergic system, contributing dysregulations vary depending intensity duration alcohol consumption. A small number interventions have been developed target but there are promising future therapeutic avenues explore. This review provides an overview impact current available AUD novel being explored could be included among first-line therapies treatment AUD.

Language: Английский

Citations

19

Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review DOI Creative Commons
Valbona Govori, Hrvoje Budinčević,

Sandra Morović

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 504 - 504

Published: March 19, 2024

Despite being highly preventable, stroke is the second-most common cause of death and disability in world. Secondary prevention critical as recurrence risk 6- to 15-fold higher than general population. Stroke associated with mortality rates increased levels. Lifestyle modifications should address not single but multiple cardiovascular factors effectively reduce stroke. on a personal level include adequate physical activity, healthy diet, cessation smoking alcohol consumption, stress reduction. Physical activities be performed environment without air pollution. According recent studies, up 90% strokes might prevented by addressing treating ten modifiable factors, half which are related lifestyle modifications. These modifications, behavioral interventions, could impact other such arterial hypertension, hyperlipidemia, obesity, diabetes, atrial fibrillation. The most obstacles effective secondary motor impairment, post-stroke cognitive depression, subtype. Long-term difficult sustain require comprehensive, individualized interventions. This review underlines benefits adhering measure.

Language: Английский

Citations

6

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years DOI Creative Commons
Simona Minzer,

Ramón Estruch,

Rosa Casas

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(21), P. 5045 - 5045

Published: Oct. 30, 2020

Dietary habits are a determining factor of the higher incidence and prevalence chronic non-communicable diseases (NCDs). In aim to find possible preventive intervention strategy, Mediterranean diet (MedDiet) has been proposed as an effective approach. Within MedDiet, moderate wine consumption with meals is positive item in MedDiet score; however, recent studies have reported dose-response association between alcohol risk large number NCDs. This review aimed evaluate NCDs framework simple 22 highest-level literature published over last five years. We found that information regarding effects different health outcomes not varied widely past years, finding inconclusive results among evaluated. Most agrees light intake seems beneficial some extent NCDs, such hypertension, cancer, dyslipidemia dementia, but no definitive recommendations can be made on specific dose benefit most diseases.

Language: Английский

Citations

40