Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A DOI Creative Commons
Chelseá B. Johnson-Hence, Kathyayini P. Gopalakrishna, Darren Bodkin

et al.

The Journal of Experimental Medicine, Journal Year: 2023, Volume and Issue: 220(8)

Published: July 18, 2023

Immunoglobulin A (IgA) is secreted into breast milk and critical for both protecting against enteric pathogens shaping the infant intestinal microbiota. The efficacy of milk–derived maternal IgA (BrmIgA) dependent upon its specificity; however, heterogeneity in BrmIgA binding ability to microbiota not known. Using a flow cytometric array, we analyzed reactivity bacteria common discovered substantial between all donors, independent preterm or term delivery. Surprisingly, also observed intradonor variability response closely related bacterial isolates. Conversely, longitudinal analysis showed that antibacterial was relatively stable through time, even sequential infants, indicating mammary gland responses are durable. Together, our study demonstrates displays interindividual but intraindividual stability. These findings have important implications how shapes development protects necrotizing enterocolitis.

Language: Английский

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants DOI
Kathyayini P. Gopalakrishna,

Benjamin R. Macadangdang,

Matthew B. Rogers

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(7), P. 1110 - 1115

Published: June 17, 2019

Language: Английский

Citations

245
Host specificity of the gut microbiome DOI
Elizabeth K. Mallott, Katherine R. Amato

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(10), P. 639 - 653

Published: May 27, 2021

Language: Английский

Citations

157
Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review DOI Open Access
Elizabeth A. Miles, Caroline E. Childs, Philip C. Calder

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 247 - 247

Published: Jan. 16, 2021

The immune system is complex: it involves many cell types and numerous chemical mediators. An immature response increases susceptibility to infection, whilst imbalances amongst components leading loss of tolerance can result in immune-mediated diseases including food allergies. Babies are born with an response. develops early life breast feeding promotes maturation protects against infections may protect long-chain polyunsaturated fatty acids (LCPUFAs) arachidonic acid (AA) docosahexaenoic (DHA) considered be important milk. AA, eicosapentaenoic (EPA) DHA also present the membranes cells act through multiple interacting mechanisms influence function. effects AA mediators derived from often different n-3 LCPUFAs (i.e., EPA DHA) them. Studies supplemental pregnant women show some on cord blood their responses. These studies demonstrate reduced sensitisation infants egg, risk severity atopic dermatitis first year life, persistent wheeze asthma at ages 3 5 years, especially children mothers low habitual intake LCPUFAs. Immune markers preterm term fed formula were similar those human milk, whereas without not. Infants who received plus (both showed a allergic disease respiratory illness than standard formula. which report differences controls that suggest better they lower over years life. Taken together, these findings play role development clinical significance, particularly regard manifestations asthma.

Language: Английский

Citations

131
Microbial transmission, colonisation and succession: from pregnancy to infancy DOI Creative Commons
Liwen Xiao, Fangqing Zhao

Gut, Journal Year: 2023, Volume and Issue: 72(4), P. 772 - 786

Published: Jan. 31, 2023

The microbiome has been proven to be associated with many diseases and used as a biomarker target in disease prevention intervention. Currently, the vital role of pregnant women newborns is increasingly emphasised. In this review, we discuss interplay corresponding immune mechanism between mothers their offspring during perinatal period. We aim present comprehensive picture microbial transmission potential imprinting before after delivery. addition, possibility utero colonisation pregnancy, which highly debated recent studies, highlight importance infant development first 3 years life. This holistic view infants will refine our current understanding pregnancy complications well early life greatly facilitate microbiome-based prenatal diagnosis treatment mother-infant-related diseases.

Language: Английский

Citations

80
Maternal breastmilk, infant gut microbiome and the impact on preterm infant health DOI Creative Commons
Claire Granger, Nicholas D. Embleton, Jeremy M. Palmer

et al.

Acta Paediatrica, Journal Year: 2020, Volume and Issue: 110(2), P. 450 - 457

Published: Aug. 15, 2020

This narrative review summarises the benefits of maternal breastmilk to both infant and mother, specifically that relate modification microbiome, how this might vary in preterm infant.We used PubMed primarily identify papers, reviews, case series editorials published English until May 2020. Based on this, we report components breastmilk, their associated hypothesised implications for clinical practice.Breastmilk is recommended as exclusive diet newborn infants because it has numerous nutritional immunological benefits. Additionally, exposure microbiome may confer a lasting effect gut health. In infant, with significant reduction necrotising enterocolitis, an inflammatory gastrointestinal disease other key morbidities, together improved neurodevelopmental outcomes.These impacts have long-term child (and mother) even after weaning. benefit likely due, part, by microbes bioactive components, provide potential areas research novel therapies high-risk infants.

Language: Английский

Citations

100
Prospecting Human Milk Oligosaccharides as a Defense Against Viral Infections DOI

Rebecca E. Moore,

Lianyan L. Xu,

Steven D. Townsend

et al.

ACS Infectious Diseases, Journal Year: 2021, Volume and Issue: 7(2), P. 254 - 263

Published: Jan. 20, 2021

In addition to providing maximal nutritional value for neonatal growth and development, human milk functions as an early defense mechanism against invading pathogens. Human oligosaccharides (HMOs), which are abundant in milk, a diverse group of heterogeneous carbohydrates with wide ranging protective effects. promoting the colonization beneficial intestinal flora, HMOs serve decoy receptors, effectively blocking attachment pathogenic bacteria. also function bacteriostatic agents, inhibiting gram-positive Based on this precedence, emerging area field has focused characterizing antiviral properties HMOs. Indeed, have been evaluated many possessing activity life-threatening infections. This targeted review provides insight into known glycan-binding interactions between select influenza, rotavirus, respiratory syncytial virus, immunodeficiency norovirus. Additionally, we role preventing necrotizing enterocolitis, disease linked viral We close discussion what is broadly regarding their coronaviruses.

Language: Английский

Citations

78
Production and Function of Immunoglobulin A DOI
Timothy W. Hand, Andrea Reboldi

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 695 - 718

Published: March 1, 2021

Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal surfaces. The structure of and the associated secretory component allow survive highly proteolytic environment surfaces but also substantially limit IgA's ability activate effector functions on immune cells. Despite these characteristics, critical for both preventing enteric infections shaping local microbiome. function determined by a distinct antigen-binding repertoire, composed antibodies with variety specificities, from permissive polyspecificity cross-reactivity exquisite specificity single epitope, which act together regulate intestinal bacteria. Development specificities shaped cues provided gut-associated lymphoid tissue, driven constantly changing intestine microbiota.

Language: Английский

Citations

67
Secretory IgA: Linking microbes, maternal health, and infant health through human milk DOI Creative Commons
Katherine Donald, Charisse Petersen, Stuart E. Turvey

et al.

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(5), P. 650 - 659

Published: May 1, 2022

Language: Английский

Citations

58
Exploring the Potential of Human Milk and Formula Milk on Infants’ Gut and Health DOI Open Access
Hui-Yuan Chong, Loh Teng‐Hern Tan, Jodi Woan‐Fei Law

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3554 - 3554

Published: Aug. 29, 2022

Early-life gut microbiota plays a role in determining the health and risk of developing diseases later life. Various perinatal factors have been shown to contribute development establishment infant microbiota. One important influencing microbial colonization composition is mode feeding. While formula milk has designed resemble human as much possible, microbiome infants who receive differs from that are fed milk. A diverse population microbes seed microbiome. Human contains nutritional components promote growth bioactive components, such oligosaccharides, lactoferrin, immunoglobulins, which immunological development. In an attempt encourage formation healthy comparable breastfed infant, manufacturers often supplement with prebiotics or probiotics, known bifidogenic effect can modulate immune system. This review aims elucidate roles on infants' health.

Language: Английский

Citations

54
Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections DOI Creative Commons
Coen Govers, Philip C. Calder, Huub F. J. Savelkoul

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 28, 2022

Respiratory infections place a heavy burden on the health care system, particularly in winter months. Individuals with vulnerable immune such as very young children and elderly, those an deficiency, are at increased risk of contracting respiratory infection. Most relatively mild affect upper tract only, but other can be more serious. These lead to pneumonia life-threatening groups. Rather than focus entirely treating symptoms infectious disease, optimizing responsiveness pathogens causing these may help steer towards favorable outcome. Nutrition have role prevention through different supporting mechanisms. contributes normal functioning various nutrients acting energy sources building blocks during response. Many micronutrients (vitamins minerals) act regulators molecular responses cells It is well described that chronic undernutrition specific micronutrient deficiencies impair many aspects response make individuals susceptible diseases, especially gastrointestinal tracts. In addition, dietary components proteins, pre-, pro- synbiotics, also animal- plant-derived bioactive further support system. Both innate adaptive defense systems contribute active antiviral immunity. The initial viral airway recognition by system leading activation form cytotoxic T cells, production neutralizing antibodies induction memory B cell responses. aim this review describe effects range anti-infective propose mechanisms which they interact tract.

Language: Английский

Citations

41