High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study DOI Open Access
Stephanie Ling,

Eleanor Broad,

Rebecca Murphy

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(12), P. 3799 - 3799

Published: Dec. 11, 2020

The worldwide pandemic of 2019 novel coronavirus disease (COVID-19) has posed the most substantial and severe public health issue for several generations, therapeutic options have not yet been optimised. Vitamin D (in its “parent” form, cholecalciferol) proposed in pharmacological management COVID-19 by various sources. We aimed to determine whether mortality was affected serum 25-hydroxyvitamin (25(OH)D) levels, vitamin status, or cholecalciferol therapy, elucidate any other predictors mortality. Patients hospitalised with were opportunistically recruited from three UK hospitals, their data collected retrospectively. Logistic regression used relationships between potential predictors, including 25(OH)D levels booster therapy. A total 986 participants studied, whom 151 (16.0%) received In primary cohort 444 patients, therapy associated a reduced risk mortality, following adjustment confounders (ORadj 0.13, 95% CI 0.05–0.35, p < 0.001). This finding replicated validation 541 patients 0.38, 0.17–0.84, = 0.018). this observational study, treatment regardless baseline appears be acute in-patients admitted COVID-19. Further work large population studies needs carried out adequate as well multi-dose clinical trials assess maximum efficacy.

Language: Английский

Enhancing immunity in viral infections, with special emphasis on COVID-19: A review DOI Open Access
Ranil Jayawardena, Piumika Sooriyaarachchi, Michail Chourdakis

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2020, Volume and Issue: 14(4), P. 367 - 382

Published: April 16, 2020

Language: Английский

Citations

554

Covid-19 and the Subsequent Lockdown Modified Dietary Habits of Almost Half the Population in an Italian Sample DOI Creative Commons
Federico Scarmozzino, Francesco Visioli

Foods, Journal Year: 2020, Volume and Issue: 9(5), P. 675 - 675

Published: May 25, 2020

The Covid-19 pandemic led to lockdowns in several parts of the world and, hence, changed some daily habits, including social interactions, ability perform sports, and-possibly-diet. Italian government established and promulgated lockdown policies on 9 March 2020. We aim at assessing effects Covid-19-induced confinement self-reported food consumption self-selected Italians by means a questionnaire that was created diffused Internet. Nearly half, i.e., 49.6% responders did not substantially modify their diet during lockdown; however, 46.1% them reported they were eating more confinement, 19.5% gained weight. In particular, we report an increase "comfort food" consumption, notably chocolate, ice-cream, desserts (42.5%) salty snacks (23.5%). addition, 42.7% percent this cohort attributed higher anxiety levels. Related this, 36.8% decrease alcohol even though 10.1% increase. Interestingly, 21.2% increased fresh fruit vegetables. Only 33.5% those who declared decreased change lower availability ease purchasing such items. Equally interesting, over half responders, 56.2%, admitted vegetables appeal while lockdown. Purchases ready-made meals reduced nearly 50%. Future large-scale similar studies should be undertaken worldwide will help public health authorities shape reactions future, unavoidable pandemics.

Language: Английский

Citations

548

COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation DOI Open Access
Ioannis Zabetakis, Ronan Lordan, Catherine Norton

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1466 - 1466

Published: May 19, 2020

The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there been considerable economic distress globally and significant loss of life. Sadly, vulnerable immunocompromised in our societies seem to be susceptible COVID-19 complications. Global public health bodies governments have ignited strategies issued advisories on various handwashing hygiene guidelines, social distancing strategies, and, most extreme cases, some countries adopted “stay place” or lockdown protocols prevent spread. Notably, are several risk factors for infection. These include presence poor nutritional status pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular (CVD), obesity, other that render patient immunocompromised. characterized systemic inflammation, which may common feature these NCDs, outcomes against COVID-19. In this review, we discuss anti-inflammatory therapies currently under investigation intended dampen cytokine storm infections. Furthermore, role diet lifestyle is considered, it known affect infections play This review speculates importance nutrition mitigation strategy support immune function amid pandemic, identifying food groups key nutrients

Language: Английский

Citations

504

Diet and physical activity during the coronavirus disease 2019 (COVID-19) lockdown (March–May 2020): results from the French NutriNet-Santé cohort study DOI Creative Commons
Mélanie Deschasaux, Nathalie Druesne‐Pecollo, Younes Esseddik

et al.

American Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 113(4), P. 924 - 938

Published: Oct. 22, 2020

Language: Английский

Citations

364

Selenium Deficiency Is Associated with Mortality Risk from COVID-19 DOI Open Access

Arash Moghaddam,

Raban Heller, Qian Sun

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(7), P. 2098 - 2098

Published: July 16, 2020

SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects those with comorbidities. Selenium (Se) is an essential trace element of importance human health well-balanced immune response. The mortality risk from severe like sepsis or polytrauma inversely related to Se status. We hypothesized that this relation also applies COVID-19. Serum samples (

Language: Английский

Citations

338

Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic DOI Open Access
Amin Gasmi, Sàdaf Noor, Torsak Tippairote

et al.

Clinical Immunology, Journal Year: 2020, Volume and Issue: 215, P. 108409 - 108409

Published: April 7, 2020

Language: Английский

Citations

304

Altered nutrition behavior during COVID-19 pandemic lockdown in young adults DOI Creative Commons
Bruno Hüber, Julius Steffen,

Jenny Schlichtiger

et al.

European Journal of Nutrition, Journal Year: 2020, Volume and Issue: 60(5), P. 2593 - 2602

Published: Dec. 1, 2020

The COVID-19 pandemic and the implemented lockdown strongly impact on everyone's daily life. Stressful situations are known to alter eating habits increase risk for obesity. In our study, we aimed investigate effect of measures nutrition behavior among young adults.In this cross-sectional enrolled 1964 voluntary participants from Bavarian universities. All were asked complete an online questionnaire, semi-quantitatively evaluating amount type food before during lockdown. Study subjects inquired give information about acquisition procurement. primary outcome was change in amount, secondary outcomes included alterations composition procurement.Our study cohort (mean age 23.3 ± 4.0 years, 28.5% male) had a mean body mass index 22.1 4.5 kg/m2. overall increased 31.2% (n = 610) decreased 16.8% 328). A multinominal regression model revealed that intake less likely male (OR, 0.7 [CI 0.6-0.9]) more with increasing BMI 1.4 1.3-2.0]), sports activity 1.3 1.2-1.8]), augmented mental stress (OR [1.1-1.7]), alteration alcohol consumption (reduced OR, 1.1-1.7], alcohol, 1.9 1.4-2.5]). Increase mainly triggered by bread (increased 46.8%, n 284) confectionary 64.4%, 389).The significantly affected adults. Further investigation evaluate long-term effects weight comorbidities warranted.

Language: Английский

Citations

284

Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol DOI Open Access
Riccardo Caccialanza, Alessandro Laviano, Federica Lobascio

et al.

Nutrition, Journal Year: 2020, Volume and Issue: 74, P. 110835 - 110835

Published: April 3, 2020

Language: Английский

Citations

259

Nutritional status of patients with COVID-19 DOI Creative Commons
Jae Hyoung Im,

Young Soo Je,

Ji Hyeon Baek

et al.

International Journal of Infectious Diseases, Journal Year: 2020, Volume and Issue: 100, P. 390 - 393

Published: Aug. 11, 2020

The relationship between immunity and nutrition is well known its role in coronavirus disease 2019 (COVID-19) also being paid great attention. However, the nutritional status of COVID-19 patients unknown. Vitamin B1, B6, B12, vitamin D (25-hydroxyvitamin D), folate, selenium, zinc levels were measured 50 hospitalized with COVID-19. Overall, 76% deficient 42% selenium deficient. No significant increase incidence deficiency was found for vitamins group showed significantly lower values than healthy control (150 people, matched by age/sex). Severe (based on a cut-off ≤10 ng/dl) 24.0% 7.3% group. Among 12 respiratory distress, 11 (91.7%) at least one nutrient. without distress 30/38 cases (78.9%; p = 0.425). These results suggest that or may decrease immune defenses against cause progression to severe disease. more precise large-scale studies are needed.

Language: Английский

Citations

258

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19 DOI Open Access
Jan Alexander, Alexey A. Tinkov, Tor A. Strand

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(8), P. 2358 - 2358

Published: Aug. 7, 2020

The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of lack vaccines specific treatments. A common factor for conditions that predispose progress is low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, heart failure, which micronutrient deficiencies may contribute. aim the present article was explore usefulness early intervention, with focus on zinc, selenium, vitamin D, relieve escalation COVID-19.

Language: Английский

Citations

242