Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1066 - 1066

Published: July 1, 2021

Olive-derived products, such as virgin olive oil (EVOO) and/or leaf extracts (OLE), exert anti-inflammatory, insulin-sensitizing and antihypertensive properties may be useful for stabilizing omega 3 fatty acids (n-3 PUFA) due to their high content in antioxidant compounds. In this study, the addition of OLE 4:0.15 (w/w) a mixture algae (AO) rich n-3 PUFA EVOO (25:75, w/w) prevents peroxides formation after 12 months storage at 30 °C. Furthermore, treatment with (2.5 mL/Kg) (100 mg/Kg) 24 month old Wistar rats 21 days improved lipid profile, increased HOMA-IR decreased serum levels miRNAs 146a. Treatment new nutraceutical also prevented age-induced insulin resistance liver, gastrocnemius visceral adipose tissue by decreasing mRNA inflammatory oxidative stress markers. Oil + attenuated alterations vascular function muscle loss expression sarcopenia-related conclusion, based on EVOO, AO is strategy improving stability final product attenuate cardiometabolic muscular disorders associated aging.

Language: Английский

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Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 13418 - 13430

Published: Nov. 24, 2024

Obesity causes fat accumulation, and sarcopenia loss of muscle mass strength; together, they worsen insulin resistance accelerate decline, creating a harmful cycle. Some supplements, along with physical exercise, could be remedies for sarcopenic obesity (SO). In this review, we aim to draw comparison between supplements studied in experimental research those evaluated clinical studies SO. studies, Sea Buckthorn—in forms such as oil, freeze-dried powder or pomace—has been shown enhance cell growth, improve gut microbiota, provide hypoglycemic benefits increase by promoting protein synthesis. Increased consumption Omega-3 fatty acids may play protective role against SO women. Melatonin positively impact reducing oxidative stress. Elevated irisin levels, observed vitamin D supplementation, prevent wasting gain improving sensitivity inflammation. There have many highlighting the potential preventing age related sarcopenia; however, effect supplementation is under-researched appears less promising. Future trials using natural hold promise, these multiple beneficial components that work synergistically treat

Language: Английский

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The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4139 - 4139

Published: Nov. 19, 2021

We analyzed the effectiveness of two nutritional interventions alone and together, EVOO DieTBra, on inflammatory profile severely obese individuals. This study was an RCT with 149 individuals aged from 18 to 65 years, a body mass index ≥ 35 kg/m

Language: Английский

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Vitamin D in women with class II/III obesity: Findings from the DieTBra trial

Clinical Nutrition ESPEN, Journal Year: 2023, Volume and Issue: 55, P. 83 - 89

Published: March 9, 2023

ObjectiveTo assess the prevalence of vitamin D deficiency and factors associated with serum levels in adult women class II/III obesity.MethodsWe analysed baseline data from 128 obesity i.e. BMI ≥35 kg/m2 who participated DieTBra clinical trial. Sociodemographic, lifestyle, sun exposure, sunscreen, dietary intake calcium D, menopause, diseases, medication, body composition were using multiple linear regression.Results128 had mean 45.53 ± 6.36, age 39.7 8.75 30.02 ng/ml 9.80. Vitamin was 14.01%. There no association between BMI, fat percentage, total waist circumference. Age group (p = 0.004), exposure/day 0.072), use sunscreen 0.168), inadequate 0.030), 0.192), menopause 0.029) lipid-lowering drugs 0.150) included regression. The following remained low D: being 40–49 years 0.003); ≥50 0.020) 0.027).ConclusionThe lower than expected. Lifestyle, exposure not associated. over 40 significantly levels.

Language: Английский

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The effect of extra virgin olive oil (EVOO) on fat mass and fat-free mass for breastfeeding mothers (0-24 months) in Makassar City, Indonesia

Journal of Education and Health Promotion, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 1, 2024

BACKGROUND: Extra Virgin Olive Oil (EVOO) is a fat source classified as monounsaturated fatty acid. Previous studies have shown that 47.5% of breastfeeding mothers less intake when compared to the Adequacy Nutrition Rate (RDA). EVOO consumption can improve composition breast milk. However, no research has been found regarding body after consuming EVOO. This study aims determine effect on 0-24 months. MATERIALS AND METHODS: The was conducted at Sudiang Raya and Tamalanrea Health Centers in Makassar City with randomized clinical trial design from January February 2023. sample months divided into intervention group (EVOO Education, n = 17) control (Nutrition 17). Instruments Bioelectrical Impedence Analysis tools. Data analysis using t -test. RESULTS: aged between ≤19 >35 years. results showed average pre-post test, % mass (FM) P 0.426 free (FFM) 0.508 ( > 0.05), meant there significant difference. Between two groups difference end study, %FM 0.469 %FFM 0.529 0.05). CONCLUSIONS: In given EVOO, it possible maintain%FM and%FFM normal percentage range, while group, decrease less/low range.

Language: Английский

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Beneficial Effects of a Mixture of Algae and Extra Virgin Olive Oils on the Age-Induced Alterations of Rodent Skeletal Muscle: Role of HDAC-4

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 44 - 44

Published: Dec. 25, 2020

Aging is associated with a progressive decline in skeletal muscle mass, strength and function (sarcopenia). We have investigated whether mixture of algae oil (25%) extra virgin olive (75%) could exert beneficial effects on sarcopenia. Young (3 months) old (24 male Wistar rats were treated vehicle or the (OM) (2.5 mL/kg) for 21 days. decreased gastrocnemius weight, total protein, myosin heavy chain mRNA. Treatment OM prevented these effects. Concomitantly, administration inflammatory state muscle; it increase pro-inflammatory interleukin-6 (IL-6) decrease anti-inflammatory interleukin-10 (IL-10) aged rats. The was not able to prevent aging-induced alterations either insulin-like growth factor I/protein kinase B (IGF-I/Akt) pathway increased expression atrogenes gastrocnemius. However, autophagy activity (ratio protein 1A/1B-light 3 (LC3b) II/I) induced by aging factors related senescence such as histone deacetylase 4 (HDAC-4), myogenin, IGF-I binding 5 (IGFBP-5). These data suggest that can be secondary its effect normalization HDAC-4 myogenin levels, making this treatment an alternative therapeutic tool

Language: Английский

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Which Diets Are Effective in Reducing Cardiovascular and Cancer Risk in Women with Obesity? An Integrative Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3504 - 3504

Published: Oct. 4, 2021

Women are more affected by obesity than men which increases their risk of cancer and cardiovascular disease (CVD). Therefore, it is important to understand the effectiveness different types diet in context women’s health. This review aims summarize scientific evidence on effects for women with impact CVD risk. included epidemiological clinical studies adult diets, such as Mediterranean (MED) diet, Traditional Brazilian Diet, Dietary Approach Stop Hypertension (DASH), intermittent fasting (IF), calorie (energy) restriction, food re-education, low-carbohydrate (LCD) a very (VLCD). Our main findings showed that although LCDs, VLCD IF difficult adhere over an extended period, they can be good options achieving improvements body weight cardiometabolic parameters. MED, DASH Diet based natural foods reduced processed foods. These diets have been associated better health outcomes, including lower prevention treatment obesity.

Language: Английский

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Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: May 2, 2022

Background Evidence on the effects of dietary interventions inflammatory markers in individuals with obesity and type 2 diabetes mellitus (T2DM) is scarce. Our study evaluated extra-virgin olive oil alone combination a traditional Brazilian diet glycemic profiles adults both T2DM class II/III obesity. Methods Adults aged 18-64 years were randomized into two intervention groups: 1) only 2) + (OliveOil+DietBra). Data sociodemographic characteristics, lifestyle, anthropometry, biochemical collected. The primary outcomes parameters markers. body mass index (BMI) weight secondary outcomes. Results Forty enrolled, 34 (85%) completed course. intake was 37.88 ± 12.50 mL/day group 37.71 12.23 OliveOil+DietBra group, no significant difference between groups (p = 0.484). Compared to had significantly lower levels fasting insulin 0.047) at end intervention, whereas other not altered. In serum cytokines, IL-1α 0.006) adiponectin 0.049) those TNFα higher 0.037). There reduction BMI compared baseline values 0.015). Conclusions effectively decreased insulin, adiponectin, suggesting its beneficial role improving T2DM. Clinical Trial Registration ClinicalTrials.gov , identifier: NCT02463435

Language: Английский

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Olive oil and body fat: a systematic review withmeta-analysis

Food & Function, Journal Year: 2023, Volume and Issue: 14(12), P. 5516 - 5536

Published: Jan. 1, 2023

Diet composition has a great impact on body composition.

Language: Английский

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Association of Pain, Severe Pain, and Multisite Pain with the Level of Physical Activity and Sedentary Behavior in Severely Obese Adults: Baseline Data from the DieTBra Trial

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(12), P. 4478 - 4478

Published: June 22, 2020

The study aimed to assess the prevalence of pain, severe and pain in four or more regions associated with physical activity sedentary behavior, as well other factors severely obese adults (Body Mass Index ≥ 35 kg/m2). Baseline data from DieTBra Trial were analyzed. outcome variables (yes/no) sites (yes/no), identified by Brazilian version Nordic Musculoskeletal Questionnaire, along presence based on Numerical Pain Rating Scale (≥8). main independent moderate vigorous (MVPA), light activity, assessed triaxial accelerometry. analyzed using multiple hierarchical Poisson regression. In 150 individuals (men, 14.67%; women, 85.33%), a mean age 39.6 ± 0.7 years, there was high (89.33%), (69.33%), (53.33%). shorter MVPA time (p = 0.010); arthritis/arthrosis 0.007) use muscle relaxants 0.026) pain; economic class C 0.033), D 0.003), arthritis arthrosis 0.025) sites. There no significant associations between behavior any three outcomes These findings indicate that, individuals, is higher pain. Future studies intervention may contribute reduction severity obesity.

Language: Английский

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