Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 257 - 257

Published: Feb. 7, 2021

Background: A key role of oxidative stress has been highlighted in the pathogenesis COVID-19. However, little said about status (OSS) COVID-19 patients hospitalized intensive care unit (ICU). Material and Methods: Biomarkers systemic OSS included antioxidants (9 assays), trace elements (3 inflammation markers (4 assays) damage to lipids assays). Results: Blood samples were drawn after 9 (7–11) 41 (39–43) days ICU stay, respectively 3 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene PAOT® score significantly decreased compared laboratory reference values. Selenium concentration was at limit lower value. By contrast, copper/zinc ratio (as a source stress) higher than values 55% while copper correlated with lipid peroxides (r = 0.95, p < 0.001). Inflammatory biomarkers (C-reactive protein myeloperoxidase) increased when normals. Conclusions: The strongly altered critically ill as evidenced by peroxidation but also deficits some (vitamin proteins) (selenium).

Language: Английский

---

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6803 - 6803

Published: June 24, 2021

Adequate amounts of a wide range micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient meet these micronutrient requirements. Mineral deficiency does not seem the result physically active life or athletic training but is more likely arise from disturbances in quality and quantity ingested food. The lack some minerals appears symbolic modern era reflecting either excessive empty calories negative energy balance drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary availability microbial composition gut. However, influence human gut microbiota on bioaccessibility bioavailability trace elements food has rarely been studied. Bacteria play role effecting mineral bioaccessibility, which further increased through fermentation cereals soaking germination crops. Moreover, probiotics have positive effect iron, calcium, selenium, zinc relation microbiome metabolism. current literature reveals beneficial effects bacteria supporting both overall This review focuses interactions several sport nutrition, as related lifestyle.

Language: Английский

---

Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113041 - 113041

Published: May 6, 2022

Lung diseases including chronic obstructive pulmonary disease (COPD), infections like influenza, acute respiratory distress syndrome (ARDS), asthma and pneumonia lung cancer (LC) are common causes of sickness death worldwide due to their remoteness, cold harsh climatic conditions, inaccessible health care facilities. Many drugs have already been proposed for the treatment diseases. Few them in clinical trials potential cure infectious Plant extracts or herbal products extensively used as Traditional Chinese Medicine (TCM) Indian Ayurveda. Moreover, it has involved inhibition certain genes/protiens effects promote regulation signaling pathways. Natural remedies scientifically proven with remarkable bioactivities considered a cheap safe source disease. This comprehensive review highlighted literature about traditional plants metabolites applications through experimental models humans. information mode mechanism studied retrieved by Google Scholar, ScienceDirect, SciFinder, Scopus Medline PubMed resources against In vitro, vivo computational studies explained natural derived from (like flavonoids, alkaloids, terpenoids) different types Probiotics also biologically active therapeutics cancer, anti-inflammation, antiplatelet, antiviral, antioxidants associated The results mentioned repurposed especially SARS-CoV-2 should be evaluated more advance applications, biological system, need validated so that we may able retrieve most challenging SARS-CoV-2.

Language: Английский

---

The role of selenium and nano selenium on physiological responses in plant: a review

Plant Growth Regulation, Journal Year: 2023, Volume and Issue: 100(2), P. 409 - 433

Published: March 24, 2023

Language: Английский

---

The impact of the COVID-19 pandemic on lifestyle behaviors in children and adolescents: an international overview

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2022, Volume and Issue: 48(1)

Published: Feb. 4, 2022

The adverse effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are not limited to the related infectious disease. In children and adolescents, serious risks due coronavirus disease 2019 (COVID-19) pandemic also its indirect effects. These include an unbalanced diet with increased risk weight excess or nutritional deficiencies, sedentary lifestyle, lack schooling, social isolation, impaired mental health.Pediatricians should be aware side COVID-19 on children's diet, physical health advise families according their needs financial resources. Moreover, a targeted therapy able offer protection against deleterious SARS-CoV-2 infection require greater effort by scientific societies find more effective prevention strategy. this context, much interest given support, contrast malnutrition stimulate immune system.

Language: Английский

---

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(3), P. 424 - 424

Published: Jan. 19, 2023

Selenium is an important dietary supplement and essential trace element incorporated into selenoproteins with growth-modulating properties cytotoxic mechanisms of action. However, different compounds selenium usually possess a narrow nutritional or therapeutic window low degree absorption delicate safety margins, depending on the dose chemical form in which they are provided to organism. Hence, nanoparticles (SeNPs) emerging as novel diagnostic platform decreased toxicity capacity enhance biological Se-based compounds. Consistent exciting possibilities offered by nanotechnology diagnosis, treatment, prevention diseases, SeNPs useful tools current biomedical research exceptional benefits potential therapeutics, enhanced bioavailability, improved targeting, effectiveness against oxidative stress inflammation-mediated disorders. In view need for developing eco-friendly, inexpensive, simple, high-throughput agents that can also ally theranostic purposes exhibit negligible side effects, biogenic receiving special attention. The present manuscript aims be reference its kind providing readership thorough comprehensive review emphasizes current, yet expanding, field promise hold among selenium-derived products to, eventually, elicit future developments. First, recalls physiological importance oligo-element introduces unique biological, physicochemical, optoelectronic, catalytic Se nanomaterials. Then, it addresses significance nanosizing pharmacological activity (pharmacokinetics pharmacodynamics) cellular interactions SeNPs. Importantly, discusses detail role biosynthesized innovative personalized nanomedicine-based therapies. Finally, this explores ongoing context SARS-CoV-2 pandemic presents key prospects translational nanomedicine.

Language: Английский

---

Selenization of Small Molecule Drugs: A New Player on the Board

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 7759 - 7787

Published: May 8, 2024

There is an urgent need to develop safer and more effective modalities for the treatment of a wide range pathologies due increasing rates drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout years, selenium (Se) has attracted great deal attention its important role in human health. Besides, growing body work unveiled that inclusion Se motifs into number molecules promising strategy obtaining novel therapeutic agents. In current Perspective, we have gathered most recent literature related incorporation different moieties scaffolds known drugs their feasible pharmaceutical applications. addition, highlight representative examples as well provide our perspective on possible future directions, promises, opportunities, challenges this ground-breaking area research.

Language: Английский

---

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1649 - 1649

Published: May 13, 2021

This review answers the question of why selenium is such an important trace element in human diet. Daily dietary intake and its content various food products discussed this paper, as well effects deficiency excess body. Moreover, biological activity selenium, which it performs mainly through selenoproteins, discussed. These specific proteins are responsible for thyroid hormone management, fertility, aging process, immunity, but their key role to maintain a redox balance cells. Furthermore, taking into account world news current SARS-CoV-2 virus pandemic, impact on course COVID-19 also Another worldwide problem number new cancer cases cancer-related mortality. Thus, last part article discusses risk based clinical trials (including NPC SELECT), systematic reviews, meta-analyses. Additionally, possible mechanisms action that prevent development.

Language: Английский

---

Nutrition and immunity: lessons for COVID-19

Nutrition and Diabetes, Journal Year: 2021, Volume and Issue: 11(1)

Published: June 23, 2021

Abstract The role of the immune system is to protect individual against pathogenic organisms. Nutrition one multiple factors that determines response and good nutrition important in supporting response. Immunity can be impaired older people, particularly those who are frail, living with obesity, malnourished low intakes micronutrients. impairments associated nutritional inadequacy increase susceptibility infection permit infections become more severe, even fatal. adverse impact poor on system, including its inflammatory component, may explanations for higher risk severe outcomes from SARS-CoV-2 seen people obesity. Studies micronutrients vitamin D zinc suggest roles reducing severity SARS-CoV-2. Good also promoting a diverse gut microbiota, which turn supports system. importance applies assuring robust responses vaccination. There many lessons study immunity relevant battle

Language: Английский

---

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: Sept. 4, 2020

SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, majority which are elderly. Selenium, a natural trace element, has key and complex role in immune system. It well documented Selenium deficiency associated with higher susceptibility to viral infections severe disease outcome. In this article, we firstly present evidence on how promotes mutations, replication virulence viruses. Next, review might be beneficial via restoration host antioxidant capacity, reduction apoptosis endothelial cell damages platelet aggregation. also appears low status common finding conditions considered at risk COVID-19, especially Finally, rationale use different stages COVID-19. been overlooked but may have significant place spectrum management, particularly vulnerable elderly, represent game changer global response

Language: Английский

---