Mechanisms of Ageing and Development, Journal Year: 2022, Volume and Issue: 202, P. 111620 - 111620
Published: Jan. 13, 2022
Language: Английский
Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 188 - 188
Published: Jan. 28, 2021
This review presents the comprehensive knowledge about bidirectional relationship between polyphenols and gut microbiome. The first part is related to polyphenols’ impacts on various microorganisms, especially bacteria, their influence intestinal pathogens. research data mechanisms of polyphenol action were collected together organized. impact groups bacteria both whole “microbiota” particular species, including probiotics, are presented. Moreover, present in food (bound matrix) was compared with purified (such as dietary supplements) well form derivatives glycosides) those aglycones. second paper discusses detail (pathways) role bacterial biotransformation most important polyphenols, production bioactive metabolites a significant human organism (both positive negative).
Language: Английский
Citations
265
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 147, P. 112658 - 112658
Published: Jan. 20, 2022
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more than three hundred million individuals and resulted in five deaths worldwide. ongoing pandemic underscored urgent need for effective preventive therapeutic measures to develop anti-viral therapy. natural compounds possess various pharmaceutical properties are reported as anti-virals. interest an drug against novel severe acute respiratory syndrome (SARS-CoV-2) from increased globally. Here, we investigated potential selected promising products. Sources data this paper current literature published context uses phytoconstituents their mechanism action reputed peer-reviewed journals. An extensive survey was done were critically analyzed get deeper insights into a few important phytoconstituents. consumption products such thymoquinone, quercetin, caffeic acid, ursolic ellagic vanillin, thymol, rosmarinic acid could improve our immune response thus possesses excellent potential. This review focuses on functions phytoconstituent alkaloids implications SARS-CoV-2. Our comprehensive analysis provides mechanistic restrain viral infection provide better solution through natural, therapeutically active agents.
Language: Английский
Citations
76
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 188 - 188
Published: Feb. 6, 2025
(Poly)phenols are a wide and heterogeneous class of substances with several potential health benefits. Their role in neuroprotection cognition is still questionable. This study’s scope to examine the possible association between total individual (poly)phenol intake, major dietary sources, severity multiple sclerosis (MS) cohort MS patients. Participants’ demographics, physical activity, smoking, information were collected, alongside clinical parameters including Expanded Disability Status Score (EDSS), Multiple Sclerosis Severity (MSSS), phenotype, current therapy. A validated 110-item food frequency questionnaire (FFQ) was used assess participants’ habits. The content foods estimated using Phenol-Explorer database. Data from 106 participants analyzed. high intake vegetables associated 4.6-fold higher probability mild (95% CI: 1.49, 14.28), whereas no found for other beverage sources. Hydroxycinnamic acids significantly related MSSS (OR: 6.55, 95% 2.15, 19.92). Although coffee differed patients severe (90.5 ± 53.9 vs. 59.4 40.8 mL/d, respectively), linear regression analysis did not confirm an MSSS. hydroxycinnamic may impact severity. Coffee’s remains unclear needs be further investigated.
Language: Английский
Citations
3
Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11
Published: Nov. 27, 2020
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial cytostatic. More recently, several synthetic analogs have also shown similar properties, some the advantage added stability. The actions these compounds on cardiovascular system not been thoroughly explored despite presenting potential. Indeed mechanisms underlying vascular effects particularly need clarifying. aim this paper is to provide a comprehensive up-to-date review current knowledge about CA derivatives in system. acid, CAPE caffeic amide (CAPA) exhibit vasorelaxant activity by acting endothelial smooth muscle cells. Vasorelaxant include increased NO secretion, modulation calcium potassium channels, adrenergic receptors. Together negative chronotropic effect, contributes lower blood pressure, as preclinical studies show. Their anti-inflammatory anti-angiogenic properties contribute important anti-atherosclerotic protect tissues against ischemia/reperfusion injuries cellular dysfunction caused different physico-chemical agents. There obvious shortage vivo further explore compounds’ potential physiology. Nevertheless, their favorable pharmacokinetic profile overall lack toxicity make suitable for clinical studies.
Language: Английский
Citations
83
Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3709 - 3709
Published: Sept. 8, 2022
Alzheimer’s disease (AD) is a progressive degenerative disorder of the central nervous system, characterized by neuroinflammation, neurotransmitter deficits, and neurodegeneration, which finally leads to neuronal death. Emerging evidence highlighted that hyperglycemia brain insulin resistance represent risk factors for AD development, thus suggesting existence an additional form, associated with glucose metabolism impairment, named type 3 diabetes. Owing limited pharmacological options, novel strategies, especially dietary approaches based on consumption polyphenols, have been addressed prevent or, at least, slow down progression. Among ferulic acid hydroxycinnamic derivative, widely distributed in nature, cereal bran fruits, known be endowed many bioactivities, antioxidant, anti-inflammatory antidiabetic, it could exploited as possible neuroprotective strategy. Considering importance bioactive molecule its widespread distribution foods medicinal plants, aim present narrative review provide overview existing preclinical clinical about properties mechanisms action acid, also focusing ability modulate homeostasis, order support further therapeutic interest
Language: Английский
Citations
43
Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7653 - 7653
Published: Nov. 7, 2022
Despite the immense therapeutic advances in field of health sciences, cancer is still to be found among global leading causes morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for treatment several types gained notable attention. Ferulic acid, a compound derived seeds, nuts, leaves, fruits, exhibits variety pharmacological effects cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, anti-inflammatory activities. This review study presents thorough overview molecular targets cellular signaling pathways modulated by ferulic acid diverse malignancies, showing high potential this phenolic developed as candidate agent novel anticancer therapeutics. In addition, current investigations develop promising synergistic formulations are also discussed.
Language: Английский
Citations
43
Food Science and Human Wellness, Journal Year: 2022, Volume and Issue: 12(2), P. 378 - 396
Published: Sept. 7, 2022
Mushrooms are experiencing a kind of renaissance as part the contemporary human diet. These valuable organisms more than food, they fit in perfectly novel market group known nutra-mycoceuticals. Immune-balancing mushroom dietary fibers and secondary metabolites such polyphenols main focus healthcare industry. Wellness cosmetic companies increasingly using extracts rich these ingredients. This review considers basic molecular immunomodulatory mechanisms action most commonly used fibers, β-glucans. The literature data on their bioavailability, metabolic transformations, preclinical clinical research, safety discussed. Immunomodulatory polyphenol ingredients also considered. molecules present great potential design new immunity balancer formulations according to widespread structural diversity. Finally, we draw attention perspectives modern trends nutraceutical cosmeceutical strengthen balance immunity.
Language: Английский
Citations
40
Ultrasonics Sonochemistry, Journal Year: 2022, Volume and Issue: 90, P. 106213 - 106213
Published: Oct. 28, 2022
Language: Английский
Citations
40
Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386
Published: July 28, 2024
Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,
Language: Английский
Citations
13
Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2502 - 2502
Published: Dec. 4, 2024
This review describes the enhanced classification of polyphenols into flavonoids, lignans, phenolic acids, stilbenes, and tannins. Its focus is natural sources an in-depth discussion their antibacterial, antifungal, antiviral activity. Besides a broad literature overview, this paper contains authors' experimental data according to some daily consumed vegetables such as tomatoes, different varieties onion, garlic, parsley, cayenne pepper probable relation these activities polyphenols. The isolation via conventional ultrasonic, pressurized liquids pulse-field extractions, well methods for detection determination, are interpreted well. main mechanisms by which inhibit growth bacteria, fungi, viruses, protein synthesis, cell membrane destabilization, ROS production induction, in focus. Data on polyphenol concentrations respective MIC or inhibition zone diameters bacterial fungal species suppressing viral replication depicted. toxicity vitro, ex vivo, vivo towards microorganisms human/animal cells, safety applied clinical industrial applications expanded. also characterizes antimicrobial effects chemically synthesized derivatives. Biotechnological advances reported, especially entrapment biocompatible nanoparticles enhance bioavailability efficacy. Polyphenols promising exploring molecules' novel substances paving path effective agents' discovery, taking consideration positives negatives.
Language: Английский
Citations
13