Carotenoids: Dietary sources, health functions, biofortification, marketing trend and affecting factors – A review

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 14, P. 100834 - 100834

Published: Oct. 27, 2023

Nutritional deficiency is becoming a universal problem, resulting in poor health, low worker productivity, high rates of mortality and morbidity. Large-scale dietary improvements are needed to deliver healthy, sustainable diet the increasing world population. Fruits vegetables as well their valorized wastes industrial by-products constitute major sources bioactive compounds, including carotenoids. Carotenoids lipophilic pigments that occur widely nature distributed plants, fish, birds, algae, archaea, yeasts, fungi, bacteria, invertebrate animals (such insects, mites, aphids). The most significant aspects carotenoids human antioxidant provitamin A activities, also color they impart our food. researched diets commonly occurring blood β-carotene, β-cryptoxanthin, lycopene, lutein α-carotene, with β-carotene comprising portion pro-vitamin A. Phytoene phytofluene recently increasingly topical diet. Genotype, environment, climate, post-harvest handling processing among factors affecting Thus, this review, results from several studies on recent developments carotenoid sources, marketability, biofortification, new insights for valorization food agro-industrial by-products, health effects concentrations compositions critically pinpointed briefly discussed. Lastly, research needs, mainly crop waste valorization, therapeutic properties highlighted so enhance production nutritional values potentially benefits.

Language: Английский

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DeepMPF: deep learning framework for predicting drug–target interactions based on multi-modal representation with meta-path semantic analysis

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 25, 2023

Abstract Background Drug-target interaction (DTI) prediction has become a crucial prerequisite in drug design and discovery. However, the traditional biological experiment is time-consuming expensive, as there are abundant complex interactions present large size of genomic chemical spaces. For alleviating this phenomenon, plenty computational methods conducted to effectively complement experiments narrow search spaces into preferred candidate domain. Whereas, most previous approaches cannot fully consider association behavior semantic information based on several schemas represent structure heterogeneous networks. Additionally, DTI single modalities satisfy demand for accuracy. Methods We propose multi-modal representation framework ‘DeepMPF’ meta-path analysis, which utilizes predict DTI. Specifically, we first construct protein–drug-disease networks composed three entities. Then feature obtained under views, containing sequence modality, modality similarity modality. proposed six representative preserve high-order nonlinear catch hidden structural network. Finally, DeepMPF generates highly comprehensive descriptors calculates probability through joint learning. Results To evaluate predictive performance DeepMPF, comparison four gold datasets. Our method can obtain competitive all also explore influence different embedding dimensions, learning strategies classification methods. Meaningfully, repositioning COVID-19 HIV demonstrate be applied solve problems reality help The further analysis molecular docking enhances credibility candidates predicted by DeepMPF. Conclusions All results capability drug-target interactions. It utilized useful tool prescreen potential protein. web server predictor freely available at http://120.77.11.78/DeepMPF/ , relevant researchers study.

Language: Английский

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The Role of Nutrition in the COVID-19 Pandemic

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1093 - 1093

Published: March 27, 2021

SARS-CoV-2, the cause of COVID-19 disease, is posing unprecedent challenges. In literature, increasing evidence highlights how malnutrition negatively affects immune system functionality, impairing protection from infections. The current review aims to summarize complex relationship between SARS-CoV-2 infection and nutritional status effects in terms disease severity, patients' recovery time, incidence complications mortality rate. Current studies evaluating possibility modulating nutrition supplementation combination with pharmacological treatments clinical setting prevent, support, overcome are also described. discussion most recent pertinent literature lay foundations for making reasonable assumptions evaluations a "best practice" against pandemic definition sound cost-effective strategies assist healthcare systems managing patients individuals their COVID-19.

Language: Английский

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Knowledge, Attitudes, and Practices Related to Dietary Supplementation, before and during the COVID-19 Pandemic: Findings from a Cross-Sectional Survey in the Lebanese Population

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(16), P. 8856 - 8856

Published: Aug. 23, 2021

At the start of 2020, a new coronavirus (COVID-19) invaded world leading to death 3.92 million people. Sadly, date, no remedy has been discovered for this virus. Preventive vaccines have under investigation, but were unavailable until December 2020. Clinical deficiencies nutrients may increase susceptibility infections. This knowledge provided an incentive some dietary supplement (DS) manufacturers advertise their products as COVID-19 preventatives or cures without any substantiation, targeting mainly social media fans. The objective research was assess usage, and attitudes towards supplementation before during pandemic among Lebanese A cross-sectional study conducted based on convenience sample (N = 2966) information from participants aged 18 years above collected about periods pandemic. Our findings showed that DSs changed when emerged people believed can improve health strengthen immunity. Despite rise in DS prescription by healthcare professionals, prevalence use decreased 73.3% 69.9% (p < 0.001). Study results declared weekly daily estimated intake had increased compared pandemic, 14% 15.6% antioxidants 0.014), 35.3% 42.1% vitamin C 0.001), 35.5% 41% D 15.2% 17.5% E 0.002), 18.8% 29.3% zinc 0.001) other vitamins minerals (from 9% 10.9%, p Binary logistic regression indicated 4 times higher those infected with COVID-19, 30 who used take 1.5 worked medical sector. To conclude, there is crucial need awareness regarding DSs.

Language: Английский

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Use of vitamin/zinc supplements, medicinal plants, and immune boosting drinks during COVID-19 pandemic: A pilot study from Benha city, Egypt

Heliyon, Journal Year: 2021, Volume and Issue: 7(3), P. e06538 - e06538

Published: March 1, 2021

The COVID-19 infection is characterized by a wide spectrum of severity that ranges from mild to severe lethal symptoms. optimal status vitamins and minerals in the body important maintain proper immune response overcome infections including COVID-19. Certain foods medicinal plants have been shown boost system.In current study, use vitamin zinc supplements, plants, honey, garlic, immune-boosting drinks among Egyptian living Benha city were investigated during corona pandemic.An online questionnaire was distributed through Google forms. A total 301 adult participants (age range: 18-82) city, Egypt included study. Chi2 goodness fit test used determine differences distribution participant responses.The C D reported 27% 17.7% participants. About one-third drinks, garlic pandemic strengthen immunity. Zingiber officinale Curcuma longa 47.2% 31.6% respectively. Concerning only 5.6% sample using it pandemic. examined nutrients found be associated with age (P < 0.05) fear score virus 0.05), but not other factors such as sex, income, educational level.The uses system common present findings may help comprehend some health practices related might considered policymakers.

Language: Английский

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COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?

Computational and Structural Biotechnology Journal, Journal Year: 2021, Volume and Issue: 19, P. 1371 - 1378

Published: Jan. 1, 2021

Coronavirus disease-19 (COVID-19)-induced severe acute respiratory syndrome is a global pandemic. As preventive measure, human movement restricted in most of the world. The Centers for Disease Control and Prevention (CDC), National Institutes Health (NIH), along with World Organization (WHO) have laid out some therapeutic guidelines infected patients. However, other than handwashing vigilance surrounding commonly encountered oronasal symptoms fever, no universally available prophylactic measure has yet been established. In pandemic, accessibility biologically active substance crucial. Ideally, it would be something readily at low price to larger percentage population minimal risk. Studies demonstrated that zinc may reduce viral replication increase immune responses. While consuming (within recommended upper safety limits), as might provide an additional shield against initiation progression COVID-19 need clinical studies, potential clearly exists. Even after vaccination, status affect vaccination

Language: Английский

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A Review of the Role of Micronutrients and Bioactive Compounds on Immune System Supporting to Fight against the COVID-19 Disease

Foods, Journal Year: 2021, Volume and Issue: 10(5), P. 1088 - 1088

Published: May 14, 2021

Micronutrients are critical for an adequate function of the immune system and play a vital role in promoting health nutritional well-being. The present work is aimed at reviewing (1) micronutrients helping to fight against COVID-19 disease through diet with food or supplements (2) potential use claims regarding according European Food Safety Authority (EFSA) requirements. Till date, there some authorized by Commission that refer certain essential nutrients (vitamins B

Language: Английский

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Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID‐19

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 94(1), P. 141 - 146

Published: Aug. 18, 2021

Due to the known anti-inflammatory and antiviral effects of zinc, 25(OH)D, vitamin B12, in this study, we explored association between serum levels these micronutrients coronavirus disease 2019 (COVID-19) patients at time admission clinical outcomes. This study was carried out on 293 with COVID-19, who were hospitalized Imam Hassan hospital (Bojnourd, Iran). We collected demographic data, characteristics, values biochemical parameters first week admission, outcomes from electronic medical records. also measured B12 within 3 days admission. Of hospitalized, median age 53 years, 147 (50.17%) female. Thirty-seven (12.62%) admitted intensive care unit (ICU), forty-two (14.32%) died. found that 25(OH)D lower died than those ICU or non-ICU survived; however, differences not statistically significant for (p > 0.05). The concentrations did affect length stay COVID-19. In general, it seems especially zinc can COVID-19 patients.

Language: Английский

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Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

Clinical Nutrition ESPEN, Journal Year: 2021, Volume and Issue: 47, P. 9 - 27

Published: Nov. 6, 2021

Language: Английский

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The effects of some essential and toxic metals/metalloids in COVID-19: A review

Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 152, P. 112161 - 112161

Published: March 29, 2021

Language: Английский

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