Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

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Therapeutic Potential of Propolis and Royal Jelly in Encephalitozoon Intestinalis Infection: An in Vitro Study

Acta Parasitologica, Journal Year: 2025, Volume and Issue: 70(1)

Published: Jan. 24, 2025

Abstract Purpose Encephalitozoon intestinalis is an obligate intracellular microsporidian fungus that causes severe gastrointestinal infections, particularly in immunocompromised individuals. Propolis (PROP), a resinous substance derived from bees, has antimicrobial, anti-inflammatory and antioxidant properties, while royal jelly (RJ) immunomodulatory, antimicrobial activities. The aim of this study was to investigate the therapeutic potential PROP RJ against E. intestinalis. Methods phenolic composition analysed by high-performance liquid chromatography with diode array detection, chemical components were evaluated according ISO12824 standards. cytotoxicity on HEK-293 cells using XTT assay. three highest non-cytotoxic concentrations each sample tested for their effects spores qRT-PCR. Trichrome-stained photomicrographs used assess spore density treated RJ. Results analysis revealed flavonoids such as quercetin, kaempferol, pinocembrin galangin, well acids caffeic cinnamic acids, known bioactive properties. contained mainly proteins, lipids, carbohydrates sugars, reflecting its role nutritionally biologically active substance. According results first evaluating effect intestinalis, all showed significant inhibitory growth compared control group. Conclusion In conclusion, we believe should be considered alternative option development antimicrosporidial drugs due medicinal pharmaceutical

Language: Английский

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Antimicrobial Properties of Hive Products and Their Potential Applications in Human and Veterinary Medicine

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 172 - 172

Published: Feb. 10, 2025

Hive products, encompassing honey, propolis, bee venom, royal jelly, and pollen, are recognized for their antimicrobial therapeutic properties. This review examines chemical composition, explores mechanisms of action, discusses potential applications in both human veterinary medicine, particularly addressing the challenge resistance. study utilized a comprehensive literature search strategy, gathering data from Google Scholar, MEDLINE PubMed, SciELO, SCOPUS databases. Relevant terms were employed to ensure thorough retrieval pertinent literature. Honey, rich bioactive compounds such as hydrogen peroxide methylglyoxal, effectively disrupts biofilms combats multi-drug-resistant pathogens, showing promise treating range infections. Propolis, with its flavonoids phenolic acids, demonstrates synergistic effects when used conjunction antibiotics. Bee component melittin, exhibits antibacterial immunomodulatory properties, although further research is needed address toxicity concerns. Pollen jelly demonstrate broad-spectrum activity, which relevant animal health. Existing pre-clinical clinical support these hive products. products represent vast largely untapped natural resource combating resistance developing sustainable therapies, field medicine. However, challenges remain due inherent variability composition lack standardized protocols preparation application. Further essential fully elucidate optimize formulations enhanced efficacy, establish safe effective use.

Language: Английский

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Molecular Insights into Royal Jelly Anti-Inflammatory Properties and Related Diseases

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1573 - 1573

Published: July 17, 2023

Royal jelly (RJ), a highly nutritious natural product, has gained recognition for its remarkable health-promoting properties, leading to widespread use in the pharmaceutical, food, and cosmetic industries. Extensive investigations have revealed that RJ possesses broad spectrum of therapeutic effects, including anti-inflammatory, antioxidant, antitumor, anti-aging, antibacterial activities. Distinctive among bee products, exhibits significantly higher water relatively lower sugar content. It is characterized by substantial protein content, making it valuable source this essential macronutrient. Moreover, contains diverse array bioactive substances, such as lipids, phenolic compounds, flavonoids, organic acids, minerals, vitamins, enzymes, hormones. This review aims provide an overview current research on components present their associated qualities. According existing literature, these substances hold great potential alternative approaches enhancing human health. Notably, emphasizes anti-inflammatory properties RJ, particularly relation inflammatory diseases, multiple sclerosis (MS), rheumatoid arthritis (RA), bowel diseases (IBD). Furthermore, we delve into antitumor antioxidant activities aiming deepen our understanding biological functions. By shedding light multifaceted benefits seeks encourage utilization inspire further investigation field.

Language: Английский

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Efficacy of propolis and royal jelly in attenuating cadmium-induced spermatogenesis and steroidogenesis dysregulation, causing infertility in rats

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(40), P. 53052 - 53073

Published: Aug. 22, 2024

Language: Английский

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Chemical Characterization and Antioxidant Activity of Apilarnil, Royal Jelly, and Propolis Collected in Banat Region, Romania

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 1242 - 1242

Published: Feb. 2, 2024

Bee products have a millennia-old tradition in human apitherapy, thanks to their numerous curative properties. The aim of this study was perform physicochemical characterization, including the percentage water content, dry matter, pH, acidity, impurity protein, ash, and macro micro minerals, evaluate antioxidant activity apiculture products, apilarnil, royal jelly, propolis. Samples were collected from our apiary Banat region Romania 2022 as well market. Apilarnil jelly analyzed pure freeze-dried form, propolis tincture form. Our results show that there is large variability chemical composition three bee studied, depending on form presentation source origin. In case commercial best obtained terms composition, content nutrients. All samples showed values within limits allowed by quality standards. own recorded highest for activity, followed fresh apiary.

Language: Английский

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Liquid chromatography-mass spectrometry profiling of propolis and royal jelly and their ameliorative effects on cadmium-instigated pathological consequences in ovarian tissues of rats

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111800 - 111800

Published: Sept. 1, 2024

Language: Английский

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Asymmetric natural wound dressing based on porous chitosan-alginate hydrogel/electrospun PCL-silk sericin loaded by 10-HDA for skin wound healing: In vitro and in vivo studies

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124976 - 124976

Published: Nov. 1, 2024

Language: Английский

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A comprehensive analysis of royal jelly protection against cypermethrin-induced toxicity in the model organism Allium cepa L., employing spectral shift and molecular docking approaches

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 203, P. 105997 - 105997

Published: June 22, 2024

Language: Английский

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Royal Jelly: A Novel Biotemplate for the Green Synthesis of Antibacterial Metal Nanoparticles

Published: Jan. 1, 2025

The application of green synthesis in nanotechnology is rapidly expanding as a safe and eco-friendly alternative to conventional methods. This study explored the potential royal jelly bio-reducing agent for synthesizing metal nanoparticles evaluated their antibacterial activity. Royal exhibited strong antioxidant activity, demonstrated by ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate)) DPPH (2,2-diphenyl-1-picrylhydrazyl) assays, comparable that Trolox. However, it showed weak effects against both Gram-positive Gram-negative bacteria. Using jelly, silver, iron, copper, zinc were synthesized, confirmed Fourier Transform Infrared Spectrometer (FTIR), ultraviolet-visible (UV-Vis), fluorescence spectroscopy, morphological analyses. significant disrupting bacterial cell walls killing bacteria, shown inhibition zone minimum inhibitory concentrations (MIC), bactericidal (MBC), scanning electron microscope (SEM) imaging. research highlights jelly's dual role reducing nanoparticle its applications.

Language: Английский

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