Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study DOI Creative Commons

Yifan Fang,

Lan Liu, Yingying Yang

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Abstract Objective This study aimed to explore the causal effect of body mass index (BMI) on polycystic ovarian syndrome (PCOS). Methods Genome-wide association data for BMI and PCOS were sourced from Mendelian randomization (MR) base platform. Significantly associated single nucleotide polymorphisms (SNPs) served as instrumental variables in bidirectional 2-sample MR analyses investigate relationship between PCOS. Analytical techniques utilized encompassed inverse variance weighted (IVW) method, median estimator, MR-Egger regression. Results We identified 427 SNPs significantly with (P < 5 × 10−8; linkage disequilibrium r2 0.001). Various methods consistently revealed a positive (IVW: odds ratio [OR] 2.027 [95% CI 1.599-2.596]; estimator: OR 2.368 1.653-3.392]; method: 3.610 1.795-7.263]), indicating that higher correlates an increased risk Additionally, we observed genetic predisposition 1.020 1.019-1.022]; 1.017 1.015-1.019]; 1.000 0.995-1.005]). Conclusion The analysis furnished compelling evidence suggesting elevated PCOS, well severity may contribute levels.

Language: Английский

Obesity and Dyslipidemia: A Review of Current Evidence DOI
Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković

et al.

Current Obesity Reports, Journal Year: 2023, Volume and Issue: 12(3), P. 207 - 222

Published: July 6, 2023

Language: Английский

Citations

62
Trends of obesity and overweight among children and adolescents in China DOI Creative Commons
Hong Ye, Rahim Ullah, Jianbing Wang

et al.

World Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 19(12), P. 1115 - 1126

Published: March 15, 2023

Recent decades have shown a rapid increase in the prevalence of overweight and obesity among Chinese children based on several national surveys. Restrictions due to coronavirus disease 2019 outbreak worsened its epidemiology. This review updates trends adolescents analyzes underlying reasons provide evidence for better policy making.

Language: Английский

Citations

44
Insulin Resistance in Polycystic Ovarian Syndrome DOI Open Access

Ananya Purwar,

Shailesh Nagpure

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 16, 2022

Polycystic ovarian syndrome (PCOS) is one of the readily recognised endocrine gland illnesses in women, with an incidence range from 2.2% to 26% India. Patients experiencing PCOS experience issues involving irregular menstrual periods, hirsutism, acne, being overweight, and impotence. Long-term, low-grade inflammation has emerged as a crucial factor leading PCOS. A rise glucose levels may stimulate oxidative stress troubling reaction mononuclear cells (MNC) females PCOS, which normally do not rely on fat. This required because MNC-derived macrophages are major source cytokine synthesis big adipose tissue similarly encourage adipocyte production. In summary, data reveal substantial risks insulin resistance obese people who suffering The findings this specific lesson indicated that individuals conventional phenotype had obesity higher resistance, neglecting absence BMI differences other phenotypes. These show most significant pathophysiological trait

Language: Английский

Citations

51
Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors DOI Open Access
Dariusz Szukiewicz,

Seweryn Trojanowski,

Anna Kociszewska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 14663 - 14663

Published: Nov. 24, 2022

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Despite its incidence, poorly understood and remains underdiagnosed, female patients are diagnosed with a delay. The heterogenous nature this complex results from combined occurrence genetic, environmental, endocrine, behavioral factors. Primary clinical manifestations PCOS derived excess androgens (anovulation, polycystic morphology, lack or scanty, irregular menstrual periods, acne hirsutism), whereas secondary include multiple metabolic, cardiovascular, psychological disorders. Dietary lifestyle factors play important roles development course PCOS, which suggests strong epigenetic environmental influences. Many studies have shown association between chronic, low-grade inflammation both ovarian tissue throughout body. In vast majority patients, elevated values inflammatory markers their gene been reported. Development vicious cycle chronic state additionally stimulated by hyperinsulinemia obesity. Changes DNA methylation, histone acetylation noncoding RNA levels presented review context oxidative stress, reactive oxygen species, signaling PCOS. Epigenetic modulation androgenic activity response to also discussed.

Language: Английский

Citations

43
Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review DOI Creative Commons
Valeria Calcaterra, Elvira Verduci,

Chiara Milanta

et al.

Children, Journal Year: 2023, Volume and Issue: 10(4), P. 695 - 695

Published: April 7, 2023

Childhood obesity represents a serious public health burden. Despite excessive dietary consumption, children with present high rates of micronutrient deficiencies, such as deficiencies in minerals and specific vitamins; may have pathogenic role obesity-related metabolic comorbidities. In this narrative review, we analyzed the main associated obesity, their clinical consequences, evidence about possible supplementation. Iron; vitamins A, B, C, D, E; folic acid; zinc; copper represent most common deficient microelements. The relationship between multiple remains unclear, different mechanisms been proposed. medical care plan for pediatric should include food choices nutritional content part crucial approach to complications. Unfortunately, only few studies are available regarding efficacy oral supplementation or weight loss treating them; thus, continuous monitoring is necessary.

Language: Английский

Citations

28
Effect of High Fat Diet on Disease Development of Polycystic Ovary Syndrome and Lifestyle Intervention Strategies DOI Open Access

Yingxue Han,

Hao Wu, Siyuan Sun

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2230 - 2230

Published: May 8, 2023

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects premenopausal women. The etiology of PCOS multifaceted, involving various genetic epigenetic factors, hypothalamic–pituitary–ovarian dysfunction, androgen excess, insulin resistance, adipose-related mechanisms. High-fat diets (HFDs) has been linked to the development disorders weight gain, exacerbating obesity impairing function axis. This results in increased hyperinsulinemia, release inflammatory adipokines, leading heightened fat synthesis reduced breakdown, thereby worsening reproductive consequences PCOS. Effective management requires lifestyle interventions such as dietary modifications, loss, physical activity, psychological well-being, well medical or surgical some cases. article systematically examines pathological basis influence HFDs on its development, with aim raising awareness connection between diet health, providing robust approach interventions, serving reference for targeted drug treatments.

Language: Английский

Citations

27
Probiotics and Polycystic Ovary Syndrome: A Perspective for Management in Adolescents with Obesity DOI Open Access
Valeria Calcaterra, Virginia Rossi,

Giulia Massini

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3144 - 3144

Published: July 14, 2023

Polycystic ovary syndrome (PCOS) affects a considerable percentage of females reproductive age. PCOS is an obesity-related condition and its effects are greatly amplified by obesity. Even though the pathogenesis remains complex has not been fully elucidated, link between obesity, PCOS, dysbiosis described. The potential role gut microbiota in development progression associated symptoms also reported. aim this narrative review to present non-systematic analysis available literature on topic probiotics adolescents with obesity order revise beneficial probiotics/symbiotic supplementation hormonal metabolic profiles inflammatory conditions. effectiveness probiotics/synbiotics supported. suggests that probiotic/symbiotic may ameliorate profiles, indicators, lipid metabolism disturbances caused PCOS. Studies show improvements weight, BMI, insulin, HOMA-IR, including it plays protecting fertility. further studies needed confirm these findings, particularly adolescent patients, probiotic be considered solution for managing

Language: Английский

Citations

27
Adipose-derived extracellular vesicles – a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome DOI
Dušan Mladenović, Milena Vesković, Nikola Šutulović

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 18 - 34

Published: Jan. 29, 2024

Language: Английский

Citations

14
Multivitamin Supplementation and Fertility Outcome: A Retrospective Single-Center Cohort Study and the Clinical and Medicolegal Value of Nutritional Counseling DOI Creative Commons
Giuseppe Gullo, Simona Zaami,

Adriana Vita Streva

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 48 - 48

Published: Jan. 2, 2025

Resveratrol can beneficially affect growth and follicle development lead to improved sperm function parameters in pre-clinical studies, while information from clinical studies is still inconclusive. This study aims evaluate the biological impact of a resveratrol-based multivitamin supplement on level II assisted reproduction cycles (IVF intracytoplasmic injection [ICSI]). A retrospective, case-control study, involving 70 infertile couples undergoing IVF/ICSI cycles, was conducted at Assisted Reproductive Center, Obstetrics Gynecology Unit-Villa Sofia-Cervello Hospital Palermo. The group underwent pre-treatment with daily nutraceutical based resveratrol, whereas control received 400 mcg/day folic acid. Primary endpoints be evaluated were number mature follicles developed (>16 mm), total oocytes Metaphase (MII) retrieved, fertilization rate, embryos/blastocysts obtained, semen quality. Secondary objectives our evaluation duration dosage gonadotropins, starting dose, blastocysts transferred frozen, implantation and, ultimately, biochemical pregnancy rates. In group, significantly higher follicles, oocytes, MII collected compared group. rate as well numbers cleavage embryos per patient, frozen obtained. shorter administration time lower dosages gonadotropins required reach maturity also observed controls, fewer dose adjustments during stimulation dose. No significant differences found or 12-month period dietary supplementation leads better effects ICSI cycles.

Language: Английский

Citations

1
The Promising Biological Role of Postbiotics in Treating Human Infertility DOI
Nader Khani, Amir Hesam Shakeri, Sousan Houshmandi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

1