Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: March 31, 2022

Over the last 10 years, there has been a growing interest in relationship between gut microbiota, brain, and neurologic-associated affections. As multiple preclinical clinical research studies highlight microbiota’s potential to modulate general state of health state, it goes without saying that microbiota plays significant role neurogenesis, mental cognitive development, emotions, behaviors, progression neuropsychiatric illnesses. Gut produces important biologic products that, through gut-brain axis, are directly connected with appearance evolution neurological psychiatric disorders such as depression, anxiety, bipolar disorder, autism, schizophrenia, Parkinson’s disease, Alzheimer’s dementia, sclerosis, epilepsy. This study reviews recent on link microbiome’s shaping development most common Moreover, special attention is paid use probiotic formulations non-invasive therapeutic opportunity for prevention management neuropsychiatric-associated

Language: Английский

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Microbial transmission, colonisation and succession: from pregnancy to infancy

Gut, Journal Year: 2023, Volume and Issue: 72(4), P. 772 - 786

Published: Jan. 31, 2023

The microbiome has been proven to be associated with many diseases and used as a biomarker target in disease prevention intervention. Currently, the vital role of pregnant women newborns is increasingly emphasised. In this review, we discuss interplay corresponding immune mechanism between mothers their offspring during perinatal period. We aim present comprehensive picture microbial transmission potential imprinting before after delivery. addition, possibility utero colonisation pregnancy, which highly debated recent studies, highlight importance infant development first 3 years life. This holistic view infants will refine our current understanding pregnancy complications well early life greatly facilitate microbiome-based prenatal diagnosis treatment mother-infant-related diseases.

Language: Английский

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Prebiotics and Probiotics for Gastrointestinal Disorders

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 778 - 778

Published: March 9, 2024

The complex role of the gut microbiome in pathogenesis gastrointestinal (GI) disorders is an emerging area research, and there considerable interest understanding how diet can alter composition function microbiome. Prebiotics probiotics have been shown to beneficially modulate microbiome, which underlies their potential for benefit GI conditions. Formulating specific recommendations public regarding these dietary supplements has difficult due significant heterogeneity between strains, doses, duration treatment investigated across studies, as well safety concerns with administering live organisms. This review aims summarize existing evidence use prebiotics various disorders, paying special attention strain-specific effects that emerged any adverse noted.

Language: Английский

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The emerging role of oxidative stress in inflammatory bowel disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn’s (CD) ulcerative colitis (UC). Although exact etiology of IBD remains uncertain, dysfunctional immunoregulation gut believed to be main culprit. Amongst immunoregulatory factors, reactive oxygen species (ROS) nitrogen (RNS), components oxidative stress event, are produced at abnormally high levels in IBD. Their destructive effects may contribute disease’s initiation propagation, as they damage lining activate inflammatory signaling pathways, further exacerbating inflammation. Oxidative markers, such malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), serum-free thiols (R-SH), can measured blood stool patients with These markers elevated IBD, their correlate severity disease. Thus, used not only diagnosis but also monitoring response treatment. It targeted treatment through use antioxidants, including vitamin C, E, glutathione, N-acetylcysteine. In this review, we summarize role pathophysiology its diagnostic targets, potential application antioxidant therapies manage treat

Language: Английский

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Milk and Its Derivatives as Sources of Components and Microorganisms with Health-Promoting Properties: Probiotics and Bioactive Peptides

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 601 - 601

Published: Feb. 16, 2024

Milk is a source of many valuable nutrients, including minerals, vitamins and proteins, with an important role in adult health. dairy products naturally containing or added probiotics have healthy functional food properties. Indeed, probiotic microorganisms, which beneficially affect the host by improving intestinal microbial balance, are recognized to immune response other biological functions. In addition macronutrients micronutrients, biologically active peptides (BPAs) been identified within amino acid sequences native milk proteins; hydrolytic reactions, such as those catalyzed digestive enzymes, result their release. BPAs directly influence numerous pathways evoking behavioral, gastrointestinal, hormonal, immunological, neurological, nutritional responses. The application drug development could improve consumer health provide therapeutic strategies for treatment prevention diseases. Herein, we review scientific literature on probiotics, products, special attention from minor species (buffalo, sheep, camel, yak, donkey, etc.); safety assessment will be also taken into consideration. Finally, recent advances foodomics unveil human discover novel peptide provided.

Language: Английский

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Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 19, 2024

Abstract Background Intestinal microbial composition not only affects the health of gut but also influences centrally mediated systems involved in mood, through “gut-brain” axis, a bidirectional communication between microbiota and brain. In this context, modulation intestinal its metabolites administration probiotics seems to represent very promising approach treatment central nervous system alterations. Early postnatal life is critical period during which brain undergoes profound essential modulations terms maturation plasticity. Maternal separation (MS), i.e., disruption mother–pup interaction, represents pivotal paradigm study stress-related mood disorders, by inducing persistent changes immune system, inflammatory processes, emotional behavior adult mammals. Results We conducted experiments investigate whether sustained consumption multi-strain probiotic formulation male mice could mitigate effects maternal separation. Our data demonstrated that with was able totally reverse anxiety- depressive-like behavior; normalize neuro-inflammatory state, restoring resting state microglia; finally induce proneurogenic effect. Mice subjected showed compared control group resulted permissive colonization administered product. As consequence, significantly affected production SCFA particular level butyrate. Conclusion Gut mediate therapeutic action mix on MS-induced dysfunctions. findings extend knowledge use as tool presence alterations sphere impact composition.

Language: Английский

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Role of probiotics and prebiotics in mitigation of different diseases

Nutrition, Journal Year: 2022, Volume and Issue: 96, P. 111602 - 111602

Published: Jan. 19, 2022

Language: Английский

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Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(3), P. 1208 - 1208

Published: Jan. 21, 2022

The consumer awareness towards healthier diets and the impact of nutrition on health has triggered an increase in production commercialization foods with claims. scientific literature classifies these food products as functional foods, a role promoting preventing diseases, they had market share almost 200 million EUR 2019. Prebiotics are considered referring to substrates that selectively utilized by host microorganisms conferring benefit, defined International Scientific Association for Probiotics Prebiotics. Several benefits associated consumption prebiotics; however, specific requirements must demonstrate causality between ingredient claimed effect. Health claims assessed European Union need be supported rigorous evidence before being authorized permitted market. Consumers’ perception this topic is influenced various stakeholders involved. current work aimed study consumers’ interest assess knowledge prebiotic concept Romania. level was quantified using web-based data tool Google Trends, questionnaire-based investigation designed. collected were analyzed help SPSS program, crosstabulation used identify influence socio-demographic characteristics diet choice prebiotics. A total 303 persons answered online applied questionnaire, grouped young consumers (15–24 years old) adults (25–64 old). Even if most responders familiar term prebiotics (74% responders), some results contradictory regarding their knowledge. emphasized carry out educational campaigns inform relationship certain ingredients outcomes clear way based assessment evidence.

Language: Английский

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Nanocarriers for Sustainable Active Packaging: An Overview during and Post COVID-19

Coatings, Journal Year: 2022, Volume and Issue: 12(1), P. 102 - 102

Published: Jan. 17, 2022

Lockdown has been installed due to the fast spread of COVID-19, and several challenges have occurred. Active packaging was considered a sustainable option for mitigating risks food systems during COVID-19. Biopolymeric-based active incorporating release compounds with antimicrobial antioxidant activity represents an innovative solution increasing shelf life maintaining quality transportation from producers consumers. However, requires certain physical, chemical, mechanical performances, which biopolymers such as proteins, polysaccharides, lipids not satisfied. In addition, low stability can easily burst when added directly into biopolymeric materials. Due these drawbacks, encapsulation lipid-based, polymeric-based, nanoclay-based nanocarriers currently captured increased interest. Nanocarriers protect control enhance performance matrices. The aim this manuscript is provide overview regarding benefits released compound-loaded in developing biopolymeric-based properties. improve properties matrix increase bioactivity compounds. Furthermore, COVID-19 pandemic brief post-COVID-19 scenario were also mentioned.

Language: Английский

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Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Gels, Journal Year: 2022, Volume and Issue: 8(8), P. 524 - 524

Published: Aug. 21, 2022

Nowadays, edible materials such as polysaccharides have gained attention due to their valuable attributes, especially gelling property. Polysaccharide-based gels (PEGs) can be classified (i) hydrogels, (ii) oleogels and bigels, (iii) aerogels, cryogels xerogels, respectively. PEGs different characteristics benefits depending on the functional groups of polysaccharide chains (e.g., carboxylic, sulphonic, amino, methoxyl) preparation method. However, are found in incipient phase research most studies related preparation, characterization, sustainable raw materials, applicability. Furthermore, all these aspects treated separately for each class PEG, without offering an overview those already obtained PEGs. The novelty this manuscript is offer classification, definition, formulation, characterization applicability food sector packaging, improving profile agent, delivery systems) medical/pharmaceutical also critically discussed. Ultimately, correlation between PEG consumption properties human health intestinal microecology, "

Language: Английский

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