Fucosylated Human Milk Oligosaccharides during the First 12 Postnatal Weeks Are Associated with Better Executive Functions in Toddlers DOI Open Access
Yvonne Willemsen, Roseriet Beijers,

Fangjie Gu

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1463 - 1463

Published: March 17, 2023

Human milk oligosaccharides (HMOs) are one of the most abundant solid components in a mother's milk. Animal studies have confirmed link between early life exposure to HMOs and better cognitive outcomes offspring. on associations with later child cognition scarce. In this preregistered longitudinal study, we investigated whether human 2'-fucosyllactose, 3'-sialyllactose, 6'-sialyllactose, grouped fucosylated HMOs, sialylated assessed during first twelve postnatal weeks, associated executive functions at age three years. At infant two, six, sample was collected by mothers who were exclusively (n = 45) or partially breastfeeding 18). HMO composition analysed use porous graphitized carbon-ultra high-performance liquid chromatography-mass spectrometry. Executive years two function questionnaires independently filled their partners, four behavioural tasks. Multiple regression analyses performed R. Results indicated that concentrations 2'-fucosyllactose functions, while worse Future frequently months experimental administration formula-fed infants can further reveal development uncover potential causality sensitive periods.

Language: Английский

Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond DOI
Cathy Lordan, Aoife K. Roche,

Dianne J. Delsing

et al.

Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(1)

Published: Jan. 11, 2024

SUMMARY Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in human breast milk. They represent an intricate mix of heterogeneous structures which reach the infant intestine intact form as they resist gastrointestinal digestion. Therefore, confer a multitude benefits, directly and/or indirectly, to developing neonate. Certain bifidobacterial species, being among earliest gut colonizers breast-fed infants, have adapted functional capacity metabolize various HMO structures. This ability is typically observed infant-associated bifidobacteria, opposed bifidobacteria associated with mature microbiota. In recent years, information has been gleaned regarding how these well certain other taxa able assimilate HMOs, including mechanistic strategies enabling their acquisition and consumption. Additionally, complex metabolic interactions occur between microbes facilitated by utilization breakdown products released from degradation. Interest HMO-mediated changes microbial composition function focal point numerous studies, times fueled availability individual biosynthetic some now commonly included formula. this review, we outline main assimilatory catabolic employed discuss that exhibit glycan degradation capacity, cover HMO-supported cross-feeding related metabolites described thus far.

Language: Английский

Citations

21
Metabolic engineering of Escherichia coli BL21(DE3) cocultured with glucose and xylose for efficient production of 2′-fucosyllactose DOI
Yunqi Zhu,

Mingli Zhao,

Hao Wang

et al.

Bioresource Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132062 - 132062

Published: Jan. 1, 2025

Language: Английский

Citations

3
Factors Contributing to Breastfeeding Cessation Among Arab Women in Israel DOI Open Access
Mahdi Tarabeih, Mohammad Sabbah,

Orsan Yahya

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 735 - 735

Published: Feb. 19, 2025

Background/Objectives: Breastfeeding provides significant health benefits for both infants and mothers, but many women discontinue earlier than recommended. This study investigates the factors contributing to early breastfeeding cessation among Arab in Israel, focusing on multiple factors, such as socio-demographic, work-related, cultural, religious, impacting duration shaping practices. Methods: A cross-sectional survey was conducted 349 women, 65% of whom were Muslim 35% Christian. Logistic regression analyses used identify key predictors cessation. Results: Findings showed that Christian more likely stop their counterparts. Mothers with four or children those balancing work demands at higher risk Contrary expectations, levels religiosity associated a greater likelihood stopping breastfeeding. Additionally, mothers who received personal guidance discontinue, suggesting potential gaps quality support provided. Conclusions: These findings underscore importance tailoring interventions address unique cultural socio-economic challenges faced by Israel. Recommendations include improving quality, workplace culturally sensitive consider role family dynamics. research valuable insights healthcare providers policymakers aiming promote sustained practices diverse populations. The highlights complexity affecting emphasizing need targeted religious influences

Language: Английский

Citations

3
Sialic acid, the secret gift for the brain DOI Creative Commons
Liu Fan,

Anna Bella Simpson,

Esmée D’Costa

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(29), P. 9875 - 9894

Published: May 9, 2022

The human brain grows rapidly in early life which requires adequate nutrition. Human milk provides optimal nutrition for the developing brain, and breastfeeding significantly improves cognition development of infants. These benefits have been largely attributed to oligosaccharides (HMOS), associated with sialic acid (Sia). Subsequently, sialylated HMOS present a vital source exogenous Sia Sialic is key molecule essential proper gangliosides, therefore critical function. Recent pre-clinical studies suggest dietary supplementation or enhances intelligence performance later life. Furthermore, emerging evidence suggests involvement homeostasis disbalance correlates common pathologies such as Alzheimer’s disease (AD). Therefore, this review will discuss health role process. Additionally, associating specific cognitive are critically assessed. assess implying potential microbiota via gut-brain axis. Finally, summarize recent advances regarding neurodegenerative roles sources.

Language: Английский

Citations

40
Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life DOI Creative Commons
Henrik M. Roager, Catherine Stanton, Lindsay J. Hall

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 21, 2023

The development of infant gut microbiome is a pivotal process affecting the ecology and function microbiome, as well host health. While establishment has been interest for decades, focus on microbial metabolism resulting small molecules (metabolites) rather limited. However, technological computational advances are now enabling researchers to profile plethora metabolites in gut, allowing improved understanding how microbial-derived drive community structuring host-microbial interactions. Here, we review current knowledge microbiota within first year life, discuss these key enhancing our basic interactions during early life developmental window.

Language: Английский

Citations

37
Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria DOI Creative Commons
L.J. Kiely,

Kizkitza Busca,

Jonathan A. Lane

et al.

FEMS Microbiology Reviews, Journal Year: 2023, Volume and Issue: 47(6)

Published: Oct. 4, 2023

Abstract A number of bacterial species are found in high abundance the faeces healthy breast-fed infants, an occurrence that is understood to be, at least part, due ability these bacteria metabolize human milk oligosaccharides (HMOs). HMOs third most abundant component after lactose and lipids, represent complex sugars which possess unique structural diversity resistant infant gastrointestinal digestion. Thus, reach distal intestine intact, thereby serving as a fermentable substrate for specific intestinal microbes, including Firmicutes, Proteobacteria, especially infant-associated Bifidobacterium spp. help shape gut microbiome. Bacteria utilising equipped with genes associated their degradation carbohydrate-active enzymes known glycoside hydrolase have been identified gut, supports this hypothesis. The resulting degraded can also be used growth substrates other present microbe-microbe interaction ‘cross-feeding’. This review describes current knowledge on HMO metabolism by particular gut-associated bacteria, many currently commercial probiotics, distinct strategies employed individual utilisation.

Language: Английский

Citations

27
Biosynthesis of Human Milk Oligosaccharides: Enzyme Cascade and Metabolic Engineering Approaches DOI
Jiawei Meng, Yingying Zhu, Hao Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(5), P. 2234 - 2243

Published: Jan. 26, 2023

Human milk oligosaccharides (HMOs) have unique beneficial effects for infants and are considered as the new gold standard premium infant formula. They a collection of unconjugated glycans, more than 200 distinct structures been identified. Generally, HMOs enzymatically produced by elongation and/or modification from lactose via stepwise glycosylation. Each glycosylation requires specific glycosyltransferase (GT) corresponding nucleotide sugar donor. In this review, typical HMO-producing GTs one-pot multienzyme modules generating various donors introduced, principles designing enzyme cascade routes HMO synthesis described, important metabolic engineering strategies mass production also reviewed. addition, future research directions in biotechnological were prospected.

Language: Английский

Citations

26
Human milk oligosaccharides: potential therapeutic aids for allergic diseases DOI Open Access

Isabel Tarrant,

B. Brett Finlay

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(8), P. 644 - 661

Published: July 11, 2023

Language: Английский

Citations

25
Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health DOI Creative Commons
Chyn Boon Wong,

Huidong Huang,

Yibing Ning

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 1014 - 1014

Published: May 17, 2024

A healthy gut microbiome is crucial for the immune system and overall development of infants. Bifidobacterium has been known to be a predominant species in infant gut; however, an emerging concern apparent loss this genus, particular, longum subsp. infantis (B. infantis) infants industrialized nations, underscoring importance restoring beneficial bacterium. With growing understanding microbiome, probiotics, especially infant-type human-residential bifidobacteria (HRB) strains like B. infantis, are gaining prominence their unique ability utilize HMOs positively influence health. This article delves into physiology probiotic strain, M-63, its symbiotic relationship with HMOs, potential improving gastrointestinal allergic conditions children. Moreover, critically assesses role trend supplementing formulas prebiotic which serve as fuel bacteria, thereby emulating protective effects breastfeeding. The review highlights combining M-63 feasible strategy improve health outcomes children, acknowledging complexities requirements further research area.

Language: Английский

Citations

14
Engineered plants provide a photosynthetic platform for the production of diverse human milk oligosaccharides DOI Creative Commons
Collin R. Barnum, Bruna Paviani, Garret Couture

et al.

Nature Food, Journal Year: 2024, Volume and Issue: 5(6), P. 480 - 490

Published: June 13, 2024

Abstract Human milk oligosaccharides (HMOs) are a diverse class of carbohydrates which support the health and development infants. The vast benefits HMOs have made them commercial target for microbial production; however, producing approximately 200 structurally at scale has proved difficult. Here we produce diversity by leveraging robust carbohydrate anabolism plants. This includes high-value complex HMOs, such as lacto- N -fucopentaose I. produced in transgenic plants provided strong bifidogenic properties, indicating their ability to serve prebiotic supplement with potential applications adult infant health. Technoeconomic analyses demonstrate that provides path large-scale production specific lower prices than platforms. Our work demonstrates promise low-cost sustainable HMOs.

Language: Английский

Citations

9