Long COVID: Long-Term Impact of SARS-CoV2

Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 711 - 711

Published: March 28, 2024

Four years post-pandemic, SARS-CoV-2 continues to affect many lives across the globe. An estimated 65 million people suffer from long COVID, a term used encapsulate post-acute sequelae of infections that multiple organ systems. Known symptoms include chronic fatigue syndrome, brain fog, cardiovascular issues, autoimmunity, dysautonomia, and clotting due inflammation. Herein, we review COVID symptoms, proposed theories behind pathology, diagnostics, treatments, clinical trials underway explore treatments for viral persistence, autonomic cognitive dysfunctions, sleep disturbances, fatigue, exercise intolerance.

Language: Английский

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Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

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Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Foods, Journal Year: 2022, Volume and Issue: 11(18), P. 2884 - 2884

Published: Sept. 17, 2022

The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment

Language: Английский

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Importance of Magnesium Status in COVID-19

Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 735 - 735

Published: May 18, 2023

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for outcome COVID-19 and Mg could be protective during COVID disease course. As an essential element, plays basic biochemical, cellular, physiological roles required cardiovascular, immunological, respiratory, neurological functions. Both low serum dietary been associated with severity outcomes, including mortality; both are also risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular hypertension, asthma. In addition, populations high rates mortality hospitalization tend consume diets in modern processed foods, which generally Mg. this review, we review describe consider possible impact on showing (1) between 2.19 2.26 mg/dL intakes > 329 mg/day course (2) inhaled improve oxygenation hypoxic patients. spite promise, oral has thus far studied only combination other nutrients. deficiency is involved occurrence aggravation neuropsychiatric complications COVID-19, memory loss, cognition, loss taste smell, ataxia, confusion, dizziness, headache. Potential zinc and/or useful increasing drug therapy effectiveness or reducing adverse effect anti-COVID-19 drugs reviewed. Oral trials patients warranted.

Language: Английский

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Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets, Mechanisms, and Insights for Therapeutic Interventions

Biology, Journal Year: 2023, Volume and Issue: 12(6), P. 843 - 843

Published: June 10, 2023

MMPs are enzymes involved in SARS-CoV-2 pathogenesis. Notably, the proteolytic activation of can occur through angiotensin II, immune cells, cytokines, and pro-oxidant agents. However, comprehensive information regarding impact different physiological systems with disease progression is not fully understood. In current study, we review recent biological advances understanding function examine time-course changes during COVID-19. addition, explore interplay between pre-existing comorbidities, severity, MMPs. The reviewed studies showed increases MMP classes cerebrospinal fluid, lung, myocardium, peripheral blood serum, plasma patients COVID-19 compared to non-infected individuals. Individuals arthritis, obesity, diabetes, hypertension, autoimmune diseases, cancer had higher levels when infected. Furthermore, this up-regulation may be associated severity hospitalization period. Clarifying molecular pathways specific mechanisms that mediate activity important developing optimized interventions improve health clinical outcomes better knowledge will likely provide possible pharmacological non-pharmacological interventions. This relevant topic might add new concepts implications for public near future.

Language: Английский

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Role of dietary supplements in the continuous battle against COVID‐19

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(2), P. 1071 - 1088

Published: Jan. 2, 2024

Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.

Language: Английский

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Oligosaccharides as Potential Regulators of Gut Microbiota and Intestinal Health in Post-COVID-19 Management

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(6), P. 860 - 860

Published: June 9, 2023

The COVID-19 pandemic has had a profound impact worldwide, resulting in long-term health effects for many individuals. Recently, as more and people recover from COVID-19, there is an increasing need to identify effective management strategies post-COVID-19 syndrome, which may include diarrhea, fatigue, chronic inflammation. Oligosaccharides derived natural resources have been shown prebiotic effects, emerging evidence suggests that they also immunomodulatory anti-inflammatory could be particularly relevant mitigating the of COVID-19. In this review, we explore potential oligosaccharides regulators gut microbiota intestinal management. We discuss complex interactions between microbiota, their functional metabolites, such short-chain fatty acids, immune system, highlighting improve manage syndrome. Furthermore, review with angiotensin-converting enzyme 2 expression alleviating Therefore, offer safe, natural, approach potentially improving health, overall outcomes

Language: Английский

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Influence Diet on Cognitive Function and Brain Health

Journal of Biomedical and Sustainable Healthcare Applications, Journal Year: 2024, Volume and Issue: unknown, P. 10 - 21

Published: Jan. 5, 2024

The functionality of an individual's brain is influenced by the interaction between various environmental factors, including diet, and genetic predispositions. objective diet in maintaining optimal function may significantly contribute to treatment prevention mental health illness. Experimental models epidemiological studies have provided evidence demonstrating that both collective specific constituents human exert influence on function. This narrative review examines five primary dimensions impact performance. topics interest include: (1) development brain; (2) networks neurotransmitters involved signaling; (3) memory cognitive processes; (4) symmetry protein synthesis breakdown; (5) detrimental consequences resulting from persistent inflammatory processes.

Language: Английский

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The osteo-metabolic phenotype of COVID-19: an update

Endocrine, Journal Year: 2022, Volume and Issue: 78(2), P. 247 - 254

Published: July 20, 2022

Language: Английский

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Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Therapeutic Advances in Musculoskeletal Disease, Journal Year: 2023, Volume and Issue: 15

Published: Jan. 1, 2023

Bone fragility is the susceptibility to fracture due poor bone strength. This condition usually associated with aging, comorbidities, disability, quality of life, and increased mortality. International guidelines for management patients include a nutritional approach, mainly aiming at optimal protein, calcium, vitamin D intakes. Several biomechanical features skeleton, such as mineral density (BMD), trabecular cortical microarchitecture, seem be positively influenced by micro- macronutrient intake. Patients major fractures are consumers dairy products, fruit, vegetables well nutrients modulating gut microbiota. The COVID-19 pandemic has further aggravated health status skeletal fragility, also in terms unhealthy dietary patterns that might adversely affect health. In this narrative review, we discuss role macro- micronutrients during pandemic.

Language: Английский

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