International Journal of General Medicine,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 1113 - 1121
Published: March 1, 2023
Infertility
is
highly
correlated
with
inflammation.
We
sought
to
evaluate
the
independent
relationships
between
each
inflammatory
marker
in
women
infertility.This
cross-sectional
study
included
1028
infertile
patients
who
were
hospitalized
at
Jining
Medical
University
January
2016
and
December
2022.
NLR
PLR
dependent
variables
measured
baseline,
respectively.
Age,
body
mass
index
(BMI),
menstrual
status
covariates.
Based
on
BMI,
population
was
split
into
two
groups:
Low-BMI
High-BMI.A
stratified
analysis
revealed
that
overweight
group
had
significantly
higher
levels
of
WBC,
platelet
count,
lymphocyte
neutrophil
count
NLR.
Comparing
normal
weight
group,
noticeably
group.
Significantly
positive
correlations
found
both
univariate
multiple
regression
analyses.There
a
significant
correlation
infertility
patients.
These
results
will
help
search
for
biomarkers
development
prediction
models.
Human Reproduction Update,
Journal Year:
2023,
Volume and Issue:
29(5), P. 570 - 633
Published: May 16, 2023
Abstract
BACKGROUND
A
normal
chromosomal
constitution
defined
through
PGT-A
assessing
all
chromosomes
on
trophectoderm
(TE)
biopsies
represents
the
strongest
predictor
of
embryo
implantation.
Yet,
its
positive
predictive
value
is
not
higher
than
50–60%.
This
gap
knowledge
causes
euploid
blastocysts’
reproductive
failure
known
as
‘the
black
box
implantation’.
OBJECTIVE
AND
RATIONALE
Several
embryonic,
maternal,
paternal,
clinical,
and
IVF
laboratory
features
were
scrutinized
for
their
putative
association
with
success
or
implantation
blastocysts.
SEARCH
METHODS
systematic
bibliographical
search
was
conducted
without
temporal
limits
up
to
August
2021.
The
keywords
‘(blastocyst
OR
day5
day6
day7
embryo)
(euploid
chromosomally
preimplantation
genetic
testing)
(implantation
miscarriage
abortion
live
birth
biochemical
pregnancy
recurrent
failure)’.
Overall,
1608
items
identified
screened.
We
included
prospective
retrospective
clinical
studies
randomized-controlled-trials
(RCTs)
that
assessed
any
feature
associated
live-birth
rates
(LBR)
and/or
(MR)
among
non-mosaic
blastocyst
transfer
after
TE
biopsy
PGT-A.
In
total,
41
reviews
372
papers
selected,
clustered
according
a
common
focus,
thoroughly
reviewed.
PRISMA
guideline
followed,
PICO
model
adopted,
ROBINS-I
ROB
2.0
scoring
used
assess
bias.
Bias
across
regarding
LBR
also
using
visual
inspection
funnel
plots
trim
fill
method.
Categorical
data
combined
pooled-OR.
random-effect
conduct
meta-analysis.
Between-study
heterogeneity
addressed
I2.
Whenever
suitable
meta-analysis,
simply
described
results.
study
protocol
registered
at
http://www.crd.york.ac.uk/PROSPERO/
(registration
number
CRD42021275329).
OUTCOMES
original
(335
studies,
30
7
RCTs)
reviews.
However,
most
retrospective,
characterized
by
small
sample
sizes,
thus
prone
bias,
which
reduces
quality
evidence
low
very
low.
Reduced
inner
cell
mass
(7
OR:
0.37,
95%
CI:
0.27–0.52,
I2
=
53%),
(9
0.53,
0.43–0.67,
70%),
overall
worse
Gardner’s
BB-grade
(8
0.40,
0.24–0.67,
83%),
developmental
delay
(18
0.56,
0.49–0.63,
47%),
(by
qualitative
analysis)
some
morphodynamic
abnormalities
pinpointed
time-lapse
microscopy
(abnormal
cleavage
patterns,
spontaneous
collapse,
longer
time
morula
formation
I,
blastulation
(tB),
duration
blastulation)
poorer
outcomes.
Slightly
lower
LBR,
even
in
context
PGT-A,
reported
women
≥38
years
0.87,
0.75–1.00,
31%),
while
obesity
both
(2
0.66,
0.55–0.79,
0%)
MR
1.8,
1.08–2.99,
52%).
experience
previous
repeated
failures
(RIF)
(3
0.72,
0.55–0.93,
0%).
By
analysis,
hormonal
assessments,
only
abnormal
progesterone
levels
prior
Among
protocols
used,
vitrified-warmed
more
effective
fresh
1.56,
1.05–2.33,
23%)
Lastly,
multiple
vitrification-warming
cycles
0.41,
0.22–0.77,
50%)
high
cells
biopsied
may
slightly
reduce
simultaneous
zona-pellucida
opening
allowed
better
results
Day
3
hatching-based
1.41,
1.18–1.69,
WIDER
IMPLICATIONS
Embryo
selection
aims
shortening
time-to-pregnancy,
minimizing
risks.
Knowing
are
competence
blastocysts
therefore
critical
define,
implement,
validate
safer
efficient
workflows.
Future
research
should
be
directed
towards:
(i)
investigations
mechanisms
involved
aging
beyond
de
novo
abnormalities,
how
lifestyle
nutrition
accelerate
exacerbate
consequences;
(ii)
improved
evaluation
uterine
blastocyst-endometrial
dialogue,
represent
boxes
themselves;
(iii)
standardization/automation
assessment
protocols;
(iv)
additional
invasive
preferably
non-invasive
tools
selection.
Only
filling
these
gaps
we
finally
crack
riddle
behind
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 28, 2024
The
influence
of
gut
microbiota
on
physiological
processes
is
rapidly
gaining
attention
globally.
Despite
being
under-studied,
there
are
available
data
demonstrating
a
microbiota-gonadal
cross-talk,
and
the
importance
this
axis
in
reproduction.
This
study
reviews
impacts
In
addition,
possible
mechanisms
by
which
modulates
male
female
reproduction
presented.
Databases,
including
Embase,
Google
scholar,
Pubmed/Medline,
Scopus,
Web
Science,
were
explored
using
relevant
key
words.
Findings
showed
that
promotes
gonadal
functions
modulating
circulating
levels
steroid
sex
hormones,
insulin
sensitivity,
immune
system,
microbiota.
Gut
also
alters
ROS
generation
activation
cytokine
accumulation.
conclusion,
demonstrate
existence
axis,
role
functions.
However,
majority
compelling
evidences
from
animal
studies
with
great
dearth
human
data.
Therefore,
validating
reports
experimental
models
important.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(1), P. 154 - 154
Published: Jan. 2, 2024
Endometriosis
is
a
chronic,
hormone-dependent
disease
characterized
by
the
presence
of
endometrial
tissue
in
ectopic
locations.
Since
treatment
options
for
this
are
still
limited,
and
cure
rate
unsatisfactory,
search
ways
to
treat
symptoms
modify
course
key
importance
improving
quality
life
patients
with
endometriosis.
So
far,
literature
has
shown
that
nutrition
can
influence
endometriosis
through
hormonal
modification
altering
inflammatory
or
oxidative
response.
subject
scientific
research,
we
aimed
summarize
current
knowledge
on
role
dietary
modifications
Our
review
showed
nutrients
anti-inflammatory
antioxidant
properties,
including
most
vitamins
several
trace
elements,
may
pathogenesis
be
considered
as
preventing
development
However,
despite
many
discoveries
described
review,
further
interdisciplinary
research
topic
seems
extremely
important,
future,
it
result
personalized
therapies
supporting
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 21, 2025
Female
infertility
is
a
multifactorial
condition
influenced
by
various
genetic,
environmental,
and
lifestyle
factors.
Recent
research
has
investigated
the
significant
impact
of
gut
microbiome
dysbiosis
on
systemic
inflammation,
metabolic
dysfunction,
hormonal
imbalances,
which
can
potentially
impair
fertility.
The
gut-brain
axis,
bidirectional
communication
system
between
brain,
also
plays
role
in
regulating
reproductive
functions.
Emerging
evidence
suggests
that
influence
brain
functions
behavior,
further
emphasizing
importance
microbiota-gut-brain
axis
reproduction.
Given
their
as
major
modulator
microbiome,
diet
dietary
factors,
including
patterns
nutrient
intake,
have
been
implicated
development
management
female
infertility.
Hence,
this
review
aims
to
highlight
patterns,
such
Western
(WD)
Mediterranean
(MD),
decipher
modulatory
action
infertile
women.
By
contrasting
detrimental
effects
WD
with
therapeutic
potential
MD,
we
emphasize
pivotal
balanced
rich
nutrients
promoting
healthy
microbiome.
These
insights
underscore
targeted
interventions
modifications
promising
strategies
enhance
outcomes
subfertile
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 4, 2023
Observation
studies
have
confirmed
the
association
between
gut
microbiome
and
reproductive
endocrine
diseases
(REDs),
namely,
polycystic
ovary
syndrome
(PCOS),
endometriosis,
female
infertility.
However,
their
has
never
been
by
a
two-sample
Mendelian
randomization
(MR)
analysis.We
conducted
MR
analysis
to
evaluate
relationship
three
aforementioned
REDs.
In
order
get
more
comprehensive
results,
two
different
thresholds
were
adopted
select
instrumental
variables
(IVs):
one
was
locus-wide
significance
threshold
(P
<1.0×10-5)
other
genome-wide
level
(P<
5×10-8).
Summary-level
statistics
for
REDs
collected
from
public
databases.
Inverse-variance
weighted
(IVW)
main
method
used
estimate
causality,
sensitivity
analyses
validate
results.At
level,
we
identified
that
genera
Streptococcus
(OR=1.52,
95%CI:
1.13-2.06,
P=0.006)
RuminococcaceaeUCG005
(OR=1.39,
1.04-1.86,
P=0.028)
associated
with
high
risk
of
PCOS,
while
Sellimonas
(OR=
0.69,
0.58-0.83,
P=0.0001)
RuminococcaceaeUCG011(OR=0.76,
0.60-0.95,
P=0.017)
linked
low
PCOS
risk.
The
genus
Coprococcus2
(OR=1.20,
1.01-1.43,
P=0.039)
correlated
an
increased
infertility,
Ruminococcus
torques
(OR=0.69,
0.54-0.88,
P=0.002)
negatively
Olsenella
1.11,
1.01-1.22,
P=0.036),
Anaerotruncus
1.25,
1.03-1.53,
P=0.025),
Oscillospira
1.21,
1.01-1.46,
P=0.035)
endometriosis.
results
showed
did
not
possess
causal
link
based
on
level.
Sensitivity
further
robustness
results.Our
study
provides
evidence
is
closely
related
Subsequent
should
be
promote
microbiome-orientated
therapeutic
strategies
managing
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2413 - 2413
Published: May 22, 2023
The
emphasis
on
healthy
nutrition
is
gaining
a
forefront
place
in
current
biomedical
sciences.
Nutritional
deficiencies
and
imbalances
have
been
widely
demonstrated
to
be
involved
the
genesis
development
of
many
world-scale
public
health
burdens,
such
as
metabolic
cardiovascular
diseases.
In
recent
years,
bee
pollen
emerging
scientifically
validated
candidate,
which
can
help
diminish
conditions
through
nutritional
interventions.
This
matrix
being
extensively
studied,
has
proven
very
rich
well-balanced
nutrient
pool.
this
work,
we
reviewed
available
evidence
interest
source.
We
mainly
focused
richness
nutrients
its
possible
roles
main
pathophysiological
processes
that
are
directly
linked
imbalances.
scoping
review
analyzed
scientific
works
published
last
four
focusing
clearest
inferences
perspectives
translate
cumulated
experimental
preclinical
into
clinically
relevant
insights.
promising
uses
for
malnutrition,
digestive
health,
disorders,
other
bioactivities
could
helpful
readjust
homeostasis
(as
it
also
true
case
anti-inflammatory
or
anti-oxidant
needs),
well
benefits
diseases,
were
identified.
knowledge
gaps
identified,
along
with
practical
challenges
hinder
establishment
fructification
these
uses.
A
complete
data
collection
made
major
range
botanical
species
allows
more
robust
clinical
information.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(20), P. 4444 - 4444
Published: Oct. 20, 2023
Polycystic
ovary
syndrome
(PCOS)
is
the
most
common
female
endocrine
disorder,
and
it
has
two
main
pathological
aspects:
reproductive
metabolic.
Overweight/obesity
a
risk
factor
in
terms
of
adverse
effects
during
hormone
stimulation,
reduced
response
to
ovulation
induction
regimens,
success
IVF,
an
increased
obstetric
complications.
To
resolve
this
vicious
cycle
events,
weight
loss
lifestyle
modifications
are
promising
strategies.
Among
these
possible
approaches,
consumption
very-low-calorie
ketogenic
diet
(VLCKD)
or
Mediterranean
(MD)
represents
valid
option.
In
our
study,
84
obese/overweight
PCOS
patients
were
recruited
evaluate
induced
by
VLCKD
MD
on
weight,
hormonal,
metabolic
parameters.
BMI
decreased
significantly
among
VLKCD
compared
(both
presenting
p
values
<
0.0001
at
90
120
days),
significant
reduction
body
circumference
was
observed.
At
same
time,
HOMA
index
statistically
for
those
(p
value
0.001
days
0.05
phenomenon
also
observed
AFC
0.001)
AMH
0.05).
Interestingly,
ovarian
hyperstimulation
(OHSS)
incidence
lower
0.001).
We
state
that
dietary
regimes
may
improve
anthropometric
parameters
(such
as
BMI)
women’s
health,
restore
menstrual
regularity,
reduce
OHSS.
Regarding
different
nutritional
therapies,
results
suggest
optimal
choice
entry
into
especially
time
range
which
achieved.