The impact of supplementing vitamin D through different methods on the prognosis of COVID-19 patients: a systematic review and meta-analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

To analyze the impact of different methods Vitamin D administration on prognosis COVID-19 patients.

Language: Английский

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EMAS position statement: Vitamin D and menopausal health

Maturitas, Journal Year: 2022, Volume and Issue: 169, P. 2 - 9

Published: Dec. 21, 2022

Language: Английский

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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

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Susceptibility to COVID-19 Nutrition Misinformation and Eating Behavior Change during Lockdowns: An International Web-Based Survey

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 451 - 451

Published: Jan. 14, 2023

To understand the susceptibility to nutrition-health misinformation related preventing, treating, or mitigating risk of COVID-19 during initial lockdowns around world, present international web-based survey study (15 April-15 May 2020) gauged participants' (

Language: Английский

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Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 27, 2024

Background The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis randomized controlled trials (RCTs). Methods Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web Science Embase. RCTs assessing mortality, intensive care unit (ICU) admission, mechanical ventilation (MV), length hospitalization (LOH), inflammatory markers containing C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), lactate dehydrogenase (LDH) were included. 19 involved in analysis conducted subgroup analyses baseline COVID-19 severity administration. Results In subgroup, statistically significant moderate severe group observed ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008), MV 0.44, 0.27, 0.72; 0.001) LOH (SMD –0.49, –0.92, −0.06; 0.027). administration 0.39, 0.16, 0.97; 0.044), 0.18, 0.07, 0.46; 0.000) –0.50, –0.96, −0.04; 0.034) more pronounced patients supplied with multiple-dose than single-dose. Although result mortality showed no effect, it indicated a reduced trend 0.87, 0.63, 1.12; > 0.05). results reached statistical differences. Conclusion This revealed that multiple doses less apt need have shorter hospital stays.

Language: Английский

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Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

COVID-19 remains globally pandemic, and although several meta-analyses have explored the association between vitamin D relative to clinical outcomes, a unified view has not yet emerged. To summarize evidence for associations levels COVID-19-related outcomes assess strength validity of these associations. PubMed, Embase, Web Science, Scopus, Cochrane Database Systematic Reviews databases were searched from January 1, 2020, June 15, 2024. Two reviewers independently extracted data assessed study quality. Low increased risk infection by 1.26- 2.18-fold, severe illness 1.50- 5.57-fold, intensive care unit (ICU) admission more than 2-fold, death 1.22- 4.15-fold. In addition, patients with deficiency had an average increase in length hospital stay 0.54 days compared high levels. Overall, supplementation may reduce severity (eg, ICU admissions, need mechanical ventilation) shorter but nonsignificant effect on mortality rates. there significant differences individuals testing positive those negative (mean difference [MD] = -3.22 ng mL-1; 95% CI, -5.18 -1.25), cases mild (MD -4.60 -5.49 -3.71), nonsurvivors survivors -6.59 CI: -8.94 -4.24). are associated higher rates, disease, rates among COVID-19, whereas patients' disease severity. The beneficial effects remain be further explored, however, higher-quality, randomized controlled studies. Nonetheless, caution is warranted because methodological quality most level very low. PROSPERO registration No. CRD42022385036.

Language: Английский

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Vitamin D, exercise, and immune health in athletes: A narrative review

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 23, 2022

Vitamin D exerts important extra-skeletal effects, exhibiting an exquisite immune regulatory ability, affecting both innate and adaptive responses through the modulation of immunocyte function signaling. Remarkably, working skeletal muscle, which is fully recognized to behave as a secretory organ with capacity, under tight control vitamin well. status, meaning hormone sufficiency or insufficiency, can push toward strengthening/stabilization decline surveillance, consequences for health. This aspect particularly relevant when considering athletic population: while exercising is, nowadays, recommended approach maintain health counteract inflammatory processes, “too much” exercise, often experienced by athletes, increase inflammation, decrease expose them higher risk diseases. When overexercise intersects hypovitaminosis D, overall effects on system might converge into depression vulnerability paper aims provide overview how shapes human responses, acting muscle cells; some aspects exercise-related modifications are addressed, focusing athletes. The crossroad where exercise meet profile whole-body response

Language: Английский

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Prevention of COVID-19 with oral vitamin D supplemental therapy in essential healthcare teams (PROTECT): protocol for a multicentre, triple-blind, randomised, placebo-controlled trial

BMJ Open, Journal Year: 2023, Volume and Issue: 13(5), P. e064058 - e064058

Published: May 1, 2023

Introduction In the COVID-19 pandemic, healthcare workers (HCWs) were at high risk of infection due to their exposure COVID infections. HCWs backbone our response this pandemic; every HCW withdrawn or lost had a substantial impact on capacity deliver care. Primary prevention was key approach reduce infection. Vitamin D insufficiency is highly prevalent in Canadians and worldwide. supplementation has been shown significantly decrease respiratory Whether reduction would apply infections remained be determined. This study aimed determine high-dose vitamin incidence laboratory-confirmed rate severity working areas. Methods analysis PROTECT triple-blind, placebo-controlled, parallel-group multicentre trial HCWs. Participants randomly allocated 1:1 ratio variable block size intervention (one oral loading dose 100 000 IU 3 +10 weekly ) control (identical placebo dose+weekly placebo). The primary outcome infection, documented by RT-qPCR salivary (or nasopharyngeal) specimens obtained for screening diagnostic purposes, as well self-obtained seroconversion endpoint. Secondary outcomes included disease severity; duration COVID-19-related symptoms; endpoint; work absenteeism; unemployment support; adverse health events. terminated prematurely, recruitment difficulty. Ethics dissemination involves human participants approved Research Board (REB) Centre hospitalier universitaire (CHU) Sainte-Justine serving central committee participating institutions (#MP-21-2021-3044). provided written informed consent participate before taking part. Results are being disseminated medical community via national/international conferences publications peer-reviewed journals. Trial registration number https://clinicaltrials.gov/ct2/show/NCT04483635 .

Language: Английский

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Vitamin D Deficiency Meets Hill’s Criteria for Causation in SARS-CoV-2 Susceptibility, Complications, and Mortality: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 599 - 599

Published: Feb. 6, 2025

Clinical trials consistently demonstrate an inverse correlation between serum 25-hydroxyvitamin D [25(OH)D; calcifediol] levels and the risk of symptomatic SARS-CoV-2 disease, complications, mortality. This systematic review (SR), guided by Bradford Hill’s causality criteria, analyzed 294 peer-reviewed manuscripts published December 2019 November 2024, focusing on plausibility, consistency, biological gradient. Evidence confirms that cholecalciferol (D3) calcifediol significantly reduce hospitalizations, mortality, with optimal effects above 50 ng/mL. While vitamin requires 3–4 days to act, shows within 24 h. Among 329 trials, only 11 (3%) showed no benefit due flawed designs. At USD 2/patient, D3 supplementation is far cheaper than hospitalization costs more effective standard interventions. SR establishes a strong relationship 25(OH)D vulnerability, meeting criteria. Vitamin infections, deaths ~50%, outperforming all patented, FDA-approved COVID-19 therapies. With over 300 confirming these findings, waiting for further studies unnecessary before incorporating them into clinical protocols. Health agencies scientific societies must recognize significance results incorporate prophylaxis early treatment protocols similar viral infections. Promoting safe sun exposure adequate communities maintain 40 ng/mL (therapeutic range: 40–80 ng/mL) strengthens immune systems, reduces hospitalizations deaths, lowers healthcare costs. When exceed 70 ng/mL, taking K2 (100 µg/day or 800 µg/week) alongside helps direct any excess calcium bones. The recommended dosage (approximately IU/kg body weight non-obese adult) 50–100 cost-effective disease prevention, ensuring health outcomes.

Language: Английский

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Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(4), P. 98 - 98

Published: April 6, 2025

A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this related to reinfections studied little. Our aim was quantify the risk of considering VitD before reinfection. We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed. Of total 644 cases confirmed laboratory tests, 378 (58.9%) included our study, an average age 38.8 years; 241 females (63.8%), 127 occurred (33.6%). reinfection incidence rates per 1000 person-days 0.50 for (<20 ng/mL), insufficient (20-29 0.37 sufficient (≥30 ng/mL). Compared status, adjusted hazard ratios 1.79 (95% confidence interval [CI] 0.89-3.59) 1.59 CI 1.06-2.38) significant inverse dose-response (p = 0.02). These results can help improve nutritional actions against reinfections. suggest that lower than 30 ng/mL showed higher Achieving maintaining is recommended prevent

Language: Английский

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