Nutrients,
Journal Year:
2023,
Volume and Issue:
15(2), P. 314 - 314
Published: Jan. 8, 2023
Advances
in
cystic
fibrosis
(CF)
care
have
significantly
improved
the
quality
of
life
and
expectancy
patients.
Nutritional
therapy
based
on
a
high-calorie,
high-fat
diet,
antibiotics,
as
well
new
therapies
focused
CFTR
modulators
change
natural
course
disease.
They
do
so
by
improving
pulmonary
function
growing
BMI.
However,
increased
weight
such
patients
can
lead
to
unwanted
long-term
cardiovascular
effects.
People
with
CF
(pwCF)
experience
several
risk
factors.
Such
factors
include
diet
dietary
intake,
altered
lipid
metabolism,
decrease
level
fat-soluble
antioxidants,
heightened
systemic
inflammation,
therapeutic
interventions,
diabetes
mellitus.
PwCF
must
pay
special
attention
food
eating
habits
order
maintain
nutritional
status
that
is
close
possible
proper
physiological
one.
also
benefit
from
appropriate
counseling,
which
essential
evolution
prognosis
Growing
evidence
collected
last
years
shows
many
bioactive
components,
phytochemicals,
polyunsaturated
fatty
acids,
antioxidants
favorable
effects
management
CF.
An
important
positive
effect
prevention.
The
possibility
preventing/reducing
enhances
both
long
run.
Current Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
31(1), P. 25 - 61
Published: May 18, 2023
Obesity
is
a
complex,
chronic
and
inflammatory
disease
that
affects
more
than
one-third
of
the
world's
population,
leading
to
higher
incidence
diabetes,
dyslipidemia,
metabolic
syndrome,
cardiovascular
diseases,
some
types
cancer.
Several
phytochemicals
are
used
as
flavoring
aromatic
compounds,
also
exerting
many
benefits
for
public
health.
This
study
aims
summarize
scrutinize
beneficial
effects
most
important
against
obesity.
Systematic
research
current
international
literature
was
carried
out
in
accurate
scientific
databases,
e.g.,
Pubmed,
Scopus,
Web
Science
Google
Scholar,
using
set
critical
representative
keywords,
such
phytochemicals,
obesity,
metabolism,
etc.
studies
unraveled
potential
positive
berberine,
carvacrol,
curcumin,
quercetin,
resveratrol,
thymol,
etc.,
obesity
disorders.
Mechanisms
action
include
inhibition
adipocyte
differentiation,
browning
white
adipose
tissue,
enzymes
lipase
amylase,
suppression
inflammation,
improvement
gut
microbiota,
downregulation
obesity-inducing
genes.
In
conclusion,
multiple
bioactive
compounds-phytochemicals
exert
Future
molecular
clinical
must
be
performed
unravel
mechanisms
anti-obesity
activities
these
naturally
occurring
compounds.
European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: April 24, 2024
Abstract
The
progression
of
heart
failure
(HF)
is
complex
and
involves
multiple
regulatory
pathways.
Iron
ions
play
a
crucial
supportive
role
as
cofactor
for
important
proteins
such
hemoglobin,
myoglobin,
oxidative
respiratory
chain,
DNA
synthetase,
in
the
myocardial
energy
metabolism
process.
In
recent
years,
numerous
studies
have
shown
that
HF
associated
with
iron
dysmetabolism,
deficiencies
overload
can
both
lead
to
development
various
myocarditis
diseases,
which
ultimately
progress
HF.
toxicity
may
be
key
targets
diagnosis,
treatment,
prevention
Some
chelators
(such
desferrioxamine),
antioxidants
ascorbate),
Fer-1,
molecules
regulate
levels
lactoferrin)
been
effective
treating
protecting
myocardium
studies.
Additionally,
certain
natural
compounds
significant
by
mediating
imbalance
iron-related
signaling
pathways
expression
levels.
Therefore,
this
review
not
only
summarizes
basic
processes
body
mechanisms
they
HF,
aim
providing
new
clues
considerations
treatment
but
also
on
chemical
components
involve
ferroptosis
its
pathology,
well
naturally
occurring
products
reference
information
inhibitors
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4915 - 4915
Published: April 30, 2024
The
process
of
adipocyte
browning
has
recently
emerged
as
a
novel
therapeutic
target
for
combating
obesity
and
obesity-related
diseases.
Non-shivering
thermogenesis
is
the
biological
heat
production
in
mammals
primarily
mediated
via
brown
adipose
tissue
(BAT).
recruitment
activation
BAT
can
be
induced
through
chemical
drugs
nutrients,
with
subsequent
beneficial
health
effects
utilization
carbohydrates
fats
to
generate
maintain
body
temperature.
However,
since
potent
may
show
adverse
side
effects,
nutritional
or
natural
substances
could
safe
effective
potential
agents.
This
review
aims
provide
an
extensive
overview
food
compounds
that
have
been
shown
activate
adipocytes
humans,
animals,
cultured
cells.
In
addition,
some
key
genetic
molecular
targets
mechanisms
action
these
reported
combat
are
discussed.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(2), P. 314 - 314
Published: Jan. 8, 2023
Advances
in
cystic
fibrosis
(CF)
care
have
significantly
improved
the
quality
of
life
and
expectancy
patients.
Nutritional
therapy
based
on
a
high-calorie,
high-fat
diet,
antibiotics,
as
well
new
therapies
focused
CFTR
modulators
change
natural
course
disease.
They
do
so
by
improving
pulmonary
function
growing
BMI.
However,
increased
weight
such
patients
can
lead
to
unwanted
long-term
cardiovascular
effects.
People
with
CF
(pwCF)
experience
several
risk
factors.
Such
factors
include
diet
dietary
intake,
altered
lipid
metabolism,
decrease
level
fat-soluble
antioxidants,
heightened
systemic
inflammation,
therapeutic
interventions,
diabetes
mellitus.
PwCF
must
pay
special
attention
food
eating
habits
order
maintain
nutritional
status
that
is
close
possible
proper
physiological
one.
also
benefit
from
appropriate
counseling,
which
essential
evolution
prognosis
Growing
evidence
collected
last
years
shows
many
bioactive
components,
phytochemicals,
polyunsaturated
fatty
acids,
antioxidants
favorable
effects
management
CF.
An
important
positive
effect
prevention.
The
possibility
preventing/reducing
enhances
both
long
run.
