Human trials exploring anti-aging medicines

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 354 - 376

Published: Jan. 4, 2024

Language: Английский

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Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 16 - 16

Published: Dec. 20, 2023

The role of neurotrophic factors, oxidative stress, and inflammation in the pathogenesis Alzheimer's disease (AD) has been explored. Animal studies have reported positive effects probiotics on these factors. Some clinical also support potential improving cognitive function via gut-brain axis older adults. However, experimental evaluating efficacy targeting factors inflammatory biomarkers, particularly among AD patients, remain very limited. In this randomized, double-blinded, active-controlled trial, we used multi-strain probiotic supplements, including

Language: Английский

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Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789

Published: March 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Language: Английский

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Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 2, 2025

The exploration of microorganisms in fermented products has become a pivotal area scientific research, primarily due to their widespread availability and profound potential improve human health. Among these, Lactiplantibacillus plantarum (formerly known as Lactobacillus plantarum) stands out versatile lactic acid bacterium, prevalent across diverse ecological niches. Its appeal extends beyond its well-documented probiotic benefits include the remarkable plasticity genome, which captivated both industrial stakeholders. Despite this interest, substantial challenges persist fully understanding harnessing L. plantarum. This review aims illuminate attributes plantarum, consolidate current advancements gene editing technologies, explore multifaceted applications wild-type genetically engineered strains.

Language: Английский

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Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients, Journal Year: 2022, Volume and Issue: 15(1), P. 51 - 51

Published: Dec. 22, 2022

Probiotics could improve cognitive functions in patients with neurological disorders such as Alzheimer’s disease, but the effects on function healthy older adults without impairment need further study. The purpose of this study was to investigate effect Bifidobacterium longum BB68S (BB68S) among impairment. A randomized, double-blind, placebo-controlled trial conducted 60 who were divided into probiotic or placebo groups and required consume either a sachet (BB68S, 5 × 1010 CFU/sachet) once daily for 8 weeks. Montreal Cognitive Assessment (MoCA) used an inclusion screening tool screen elderly participants our study, Repeatable Battery Neuropsychological Status (RBANS) assess subjects before after intervention assessment tool. significantly improved subjects’ (total RBANS score increased by 18.89 points intervention, p < 0.0001), especially immediate memory, visuospatial/constructional, attention, delayed memory domains. relative abundances beneficial bacteria Lachnospira, Bifidobacterium, Dorea, Cellulosilyticum, while decreasing those related cognition impairment, Collinsella, Parabacteroides, Tyzzerella, Bilophila, unclassified_c_Negativicutes, Epulopiscium, Porphyromonas, Granulicatella. In conclusion, along having regulatory their gut microbiota. This supports probiotics strategy promote aging advances research.

Language: Английский

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Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

It is estimated that 90% of hyperuricemia cases are attributed to the inability excrete uric acid (UA). The two main organs in charge excreting UA kidney (70%) and intestine (30%). Previous studies have reported punicalagin (PU) could protect against intestinal damages, which makes it a potential candidate for alleviating hyperuricemia. However, effects deeper action mechanisms PU managing still unknown. To investigate effect ameliorating on were assessed using mice model. Phenotypic parameters, metabolomics analysis, 16S rRNA sequencing applied explore fundamental inside improving administration significantly decreased elevated serum (SUA) levels mice, effectively alleviated damage caused by In kidney, down-regulated expression resorption protein URAT1 GLUT9, while up-regulating excretion ABCG2 OAT1 as mediated via activation MAKP/NF-κB mice. Additionally, attenuated renal glycometabolism disorder, contributed dysfunction inflammation. Similarly, increased inhibiting Furthermore, restored gut microbiota dysbiosis This research revealed impacts restoring be considered development nutraceuticals used UA-lowering agent.

Language: Английский

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Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1352 - 1352

Published: April 30, 2024

In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed examine the efficacy psychobiotics—probiotics beneficial mental health via gut–brain axis—in adults with psychiatric and cognitive disorders. Out 51 studies involving 3353 patients where half received psychobiotics, there notably high measurement effectiveness specifically in treatment depression symptoms. Most participants were older female, treatments commonly utilizing strains Lactobacillus Bifidobacteria over periods ranging 4 24 weeks. Although general agreement on variability approaches presentations limits comparability generalization findings. This underscores need for more personalized optimization deeper investigation into mechanisms through which psychobiotics act. The research corroborates therapeutic potential represents progress management

Language: Английский

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Influence of human gut microbiome on the healthy and the neurodegenerative aging

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 194, P. 112497 - 112497

Published: June 27, 2024

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.

Language: Английский

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Probiotics as modulators of gut-brain axis for cognitive development

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Various microbial communities reside in the gastrointestinal tract of humans and play an important role immunity, digestion, drug metabolism, intestinal integrity, protection from pathogens. Recent studies have revealed that gut microbiota (GM) is involved communication with brain, through a bidirectional network known as gut-brain axis. This involves humoral, immunological, endocrine, neural pathways. Gut dysbiosis negatively impacts these pathways, leading to neurological complications cognitive deficits. Both pre-clinical clinical demonstrated probiotics can restore healthy GM, reduce pH, inflammation pathogenic microbes gut. Additionally, improve cell-to-cell signaling increase blood-brain-derived neurotrophic factors. Probiotics emerge potential approach for preventing managing Despite promising findings, safety concerns possible risks probiotic usage must be closely monitored addressed. review article provides brief overview significance health.

Language: Английский

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Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4175 - 4175

Published: Sept. 27, 2023

Bifidobacterium animalis subsp. lactis GCL2505 has been shown to have some positive effects on health, including improved defecation frequency and reduced visceral fat. These are thought be due GCL2505′s unique ability reach the intestine in a viable form proliferate after single intake. This leads an increased number of intestinal bifidobacteria. randomized, double-blind, placebo-controlled, parallel-group study was conducted confirm that intake inulin (a prebiotic) improve cognitive function (n = 80). Participants consumed test drinks containing 1 × 1010 colony-forming units per 100 g 2.0 for 12 weeks. The change assessment scores set as primary endpoint. There were significant improvements neurocognitive index domain, which is overall function, addition attention, flexibility, executive domains. intervention significantly fecal bifidobacteria affected levels several inflammatory markers. results suggest improves by improving environment alleviating inflammation.

Language: Английский

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