KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites DOI Creative Commons
Ludovica Mana, Fang Chen, Xiaoxia Yuan

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Background Alzheimer’s disease (AD) is a degenerative of the central nervous system characterized by progressive cognitive impairment and memory loss. Chinese medicine’s therapeutic effect on AD has become promising treatment option in recent years, herbal compound Kai Xin San-Jia Wei (KXSJW) one its representatives. This study employed comprehensive approach, including 16S rRNA Gaschromatography-mass spectrometry (GC-MS) analysis, to investigate efficacy intrinsic mechanism KXSJW AD. Methods 50 3-month-old APP swe /PS1 dE9 transgenic mice were randomly divided into 5 groups (n = 10): model group (M), donepezil (Don), KXSJW-low dose (KJW-L), KXSJW- medium (KJW-M), KXSJW-high (KJW-H), Ten C57BL/6 J wild-type selected as control (C). The administered saline gavage, was (0.92 mg/kg/d), KXSJW-low/medium/high extract (0.9/1.8/3.6 mL/kg/d); each treated once daily for 2 months. Morris Water Maze (MWM) evaluate learning abilities. Pathological changes colon tissue assessed through hematoxylin eosin (HE) staining. Analysis gut microbiota conducted using sequencing, microbial metabolite (short chain fatty acids, SCFAs) content detected GC-MS. Colonic barrier integrity examined immunohistochemistry western blot, while β-amyloid deposition brain assessed. ELISA used measure serum intestinal peptide hormones (Glucagon, GHRP-Ghrelin). Results enhanced ability memory, reduced amyloid mice. able restore balance flora regulate concentration metabolites, especially represented Firmicutes major butyric acid. Meanwhile, restored function improved release level GHRP-Ghrelin) indicates that can improve internal environment Conclusion may homeostasis AD, with focus regulation microorganisms their subsequently Traditional Medicine (TCM) potential intervene multilevel interaction brain-gut-axis.

Language: Английский

Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders DOI Creative Commons
Maria Scuto,

Francesco Rampulla,

Giuseppe Maria Reali

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

Citations

29
Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications DOI Creative Commons
Zhiqi Zhang, Huifeng Niu,

Qiu Qu

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 2, 2025

The exploration of microorganisms in fermented products has become a pivotal area scientific research, primarily due to their widespread availability and profound potential improve human health. Among these, Lactiplantibacillus plantarum (formerly known as Lactobacillus plantarum) stands out versatile lactic acid bacterium, prevalent across diverse ecological niches. Its appeal extends beyond its well-documented probiotic benefits include the remarkable plasticity genome, which captivated both industrial stakeholders. Despite this interest, substantial challenges persist fully understanding harnessing L. plantarum. This review aims illuminate attributes plantarum, consolidate current advancements gene editing technologies, explore multifaceted applications wild-type genetically engineered strains.

Language: Английский

Citations

2
Beyond the Hayflick limit: How microbes influence cellular aging DOI
Mohammad Abavisani,

Saba Faraji,

Negar Ebadpour

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

Citations

2
Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review DOI Open Access
Manuel Reiriz, Ana Isabel Beltrán-Velasco, Víctor Echeverry‐Alzate

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 391 - 391

Published: Jan. 22, 2025

Background/Objectives: This systematic review focused on collecting the most significant findings impact of administration Bifidobacterium infantis (or longum subps. infantis) and breve, alone, in conjunction, or combination with other strains, treatment neurodegenerative diseases including Alzheimer’s disease (AD) Parkinson’s (PD). These are characterized by progressive degeneration neurons, resulting a broad spectrum clinical manifestations. AD is typified decline cognitive abilities, while PD marked motor symptoms associated loss dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, Web Science (WoS), were reviewed studies screened for inclusion following criteria: (i) that specifically evaluated use infantis, subsp. breve as therapeutic intervention, either human animal models, context diseases; (ii) required to address one more pathologies examined this article, included, but not limited to, neurodegeneration, disease, oxidative stress; (iii) full text was accessible online; (iv) article written English. Results: The data suggest these probiotics have neuroprotective effects may delay progression. Conclusions: study provides updated insights into strains like PD, main limitation being number trials available.

Language: Английский

Citations

2
The gut microbiota–brain axis in neurological disorders DOI Creative Commons

Mingming You,

Nan Chen, Yuanyuan Yang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

Citations

15
Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits DOI Creative Commons
Yeonhee Pyo, Ki Han Kwon,

Yeon Ja Jung

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386

Published: July 28, 2024

Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,

Language: Английский

Citations

11
Modulation of gut microbiome in the treatment of neurodegenerative diseases: A systematic review DOI Creative Commons

A. Mincic,

Miklós Antal, Lorena Filip

et al.

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(7), P. 1832 - 1849

Published: May 31, 2024

Language: Английский

Citations

10
Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double‐Blind Randomized Placebo‐Controlled Crossover Trial DOI Creative Commons
Cristofer Ruiz‐González,

Diana Cardona,

Lola Rueda-Ruzafa

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Abstract As the population ages, cognitive decline becomes more common. Strategies targeting gut-brain axis using probiotics are emerging to achieve improvements in neuropsychiatric and neurological disorders. However, beneficial role of on brain function healthy older adults remains unclear. Our aim was evaluate a multi-species probiotic formulation as therapeutic approach reduce emotional associated with aging adults. A randomized double-blind placebo-controlled crossover trial conducted. The study involved 10-week intervention where participants consumed assigned product daily, followed by 4-week washout period before second condition started. Cognitive assessed Mini-Mental State Examination (MMSE) Psychological Experiments Construction Language Test Battery. At level, Beck Depression Inventory (BDI) State-Trait Anxiety (STAI) were used. Thirty-three participants, recruited between July 2020 April 2022, ingested multispecies ( Lactobacillus rhamnosus Bifidobacterium lactis ). After intervention, noticeable enhancements observed (mean difference 1.90, 95% CI 1.09 2.70, p < 0.005), memory 4.60, 2.91 6.29, 0.005) MMSE digit task, depressive symptoms 4.09, 1.70 6.48, BDI. Furthermore, there significant planning problem-solving skills, selective attention, flexibility, impulsivity, inhibitory ability. Probiotics administration improved Limited research supports this, requiring scientific evidence for an effective therapy decline. This has been prospectively registered at ClinicalTrials.gov (NCT04828421; 2020/July/17).

Language: Английский

Citations

9
Health-Promoting Effects of Lactobacillus acidophilus and Its Technological Applications in Fermented Food Products and Beverages DOI Creative Commons
Yanyan Liu,

Hira Nawazish,

Muhammad Salman Farid

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(8), P. 380 - 380

Published: July 25, 2024

Lactobacillus acidophilus is a probiotic bacterium that possesses numerous health-promoting properties and has significant technological applications in the fermentation of wide range food products beverages. This review discusses health benefits L. acidophilus, including its ability to enhance immunity; promote digestive wellness; exhibit antioxidant, antitumor, antimicrobial properties. also production bioactive peptides extracellular polysaccharides (EPS) by acidophilus. Factors, such as salinity, temperature, carbon sources, nutrient availability, influence growth which can affect survival potential fermented products. The proteolytic effects contribute protein breakdown, leads release with various benefits. dairy products, cereal beverages, soymilk, fruit vegetable juices, other functional preparations, highlighting for improving nutritional value, organoleptic properties, delivery these highlights importance understanding controlling conditions maximize beverage

Language: Английский

Citations

8
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Marius Turnea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

Citations

7