Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 24, 2024

Abstract Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation-induced damage. This mode differentiates from classical in terms morphology biochemistry. stands out for its exceptional biological characteristics has garnered extensive research conversations as death. Its dysfunctional activation is closely linked to the onset diseases, particularly inflammation cancer, making ferroptosis promising avenue combating these conditions. As such, exploring may offer innovative approaches treating cancer inflammatory diseases. Our review provides insights into relevant regulatory mechanisms ferroptosis, examining impact ferroptosis-related factors both physiological pathological perspectives. Describing crosstalk between tumor- inflammation-associated signaling pathways potential inducers overcoming drug-resistant cancers are discussed, aiming inform further novel therapeutic directions relation

Language: Английский

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Overview of T-2 Toxin Enterotoxicity: From Toxic Mechanisms and Detoxification to Future Perspectives

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(7), P. 3314 - 3324

Published: Feb. 8, 2024

Fusarium species produce a secondary metabolite known as T-2 toxin, which is the primary and most harmful toxin found in type A trichothecenes. widely food grain-based animal feed endangers health of both humans animals. exposure animals occurs primarily through administration; therefore, first organ that targets gut. In this overview, research progress, toxicity mechanism, detoxification were reviewed, future directions proposed. damages intestinal mucosa destroys structure barrier function; furthermore, disrupts microbiota, causes flora disorders, affects normal metabolic function, kills epidermal cells by inducing oxidative stress, inflammatory responses, apoptosis. The mechanism intestine stress. Currently, selenium plant extracts are mainly used to exert antioxidant effects alleviate enterotoxicity toxin. studies, use genomic techniques find upstream signaling molecules associated with enterotoxin will provide new ideas for prevention toxicity. purpose paper review progress on propose treatment

Language: Английский

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Ferroptosis: Promising approach for cancer and cancer immunotherapy

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216152 - 216152

Published: April 4, 2023

Language: Английский

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Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 169927 - 169927

Published: Jan. 8, 2024

Language: Английский

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NAD⁺ precursors promote the restoration of spermatogenesis in busulfan-treated mice through inhibiting Sirt2-regulated ferroptosis

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2622 - 2636

Published: Jan. 1, 2024

In recent years, nicotinamide adenine dinucleotide (NAD

Language: Английский

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Deoxynivalenol induces testicular ferroptosis by regulating the Nrf2/System Xc−/GPX4 axis

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 175, P. 113730 - 113730

Published: March 15, 2023

Language: Английский

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Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 11, 2024

Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function ferroptosis in aetiology development cancer other disorders. Consequently, harnessing for disease treatment has diverted interest researchers field basic clinical research. The ubiquitin-proteasome system (UPS) represents a primary protein degradation pathway eukaryotes. It involves labelling proteins be degraded ubiquitin (Ub), followed recognition proteasome. Dysfunction UPS can contribute diverse pathological processes, emphasizing importance maintaining organismal homeostasis. regulation stability critical component intricate molecular mechanism underlying death. Moreover, involvement regulating death-related molecules signaling pathways, providing valuable insights targeted strategies. Besides, it highlights potential as promising target therapy, combination between UPS. mechanisms ferroptosis, including key regulators such glutathione peroxidase 4 (GPX4), cysteine/glutamate transporter (system XC-), metabolism, are thoroughly examined, alongside role modulating abundance activity crucial ferroptotic death, GPX4, nuclear factor erythroid 2–related 2 (NRF2). As pivotal regulatory macromolecular homeostasis, substantially impacts directly or indirectly associated pathways. This review explores diseases with ferroptosis.

Language: Английский

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JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115247 - 115247

Published: July 13, 2023

The most prevalent contaminated mycotoxin in feed and grain is T-2 toxin. toxin's primary action target the gut because it main organ of absorption. toxin can cause intestinal damage, but, few molecular mechanisms have been elucidated. It important to discover key pathways by which causes enterotoxicity. In this research, IPEC-J2 cells are used as a cell model investigate function MAPK signaling pathway toxin-induced epithelial damage. Throughout results functional impairment reducing TJ proteins Claudin, Occludin-1, ZO-1, N-cadherin, CX-43 expression. significantly reduced survival increased LDH release dose-dependent way. induced oxidative stress raising ROS MDA content, mitochondrial damage was indicated decline MMP an increase opening degree MPTP. upregulated expression ERK, P38 JNK, triggered pathway. addition, caused inflammation responses reflected levels inflammation-related factors IL-8, p65, P-p65 IL-6, down-regulated IL-10 level. Inhibition JNK molecule ease inflammatory response. conclusion, consequence activating molecule, induced, impair cellular inflammation.

Language: Английский

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Zearalenone induces liver injury in mice through ferroptosis pathway

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 952, P. 175875 - 175875

Published: Aug. 30, 2024

Language: Английский

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Emerging roles of ferroptosis in male reproductive diseases

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 28, 2023

Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid peroxidation that leads to excessive in different cells. distinct from other forms and associated with various diseases. Iron essential for spermatogenesis male reproductive function. Therefore, it not surprising new evidence supports the role ferroptosis testicular injury. Although molecular mechanism which induces disease unknown, several genes pathways have been linked dysfunction. In this review, we discuss iron metabolism, ferroptosis, related regulatory pathways. addition, analyze endogenous exogenous factors terms metabolism dysfunction, as well summarize relationship between Finally, potential strategies target treating diseases provide directions preventing

Language: Английский

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