Molecules,
Journal Year:
2023,
Volume and Issue:
28(7), P. 3267 - 3267
Published: April 6, 2023
Green
alga
Caulerpa
racemosa
is
an
underexploited
species
of
macroalgae,
even
though
it
characterized
by
a
green
color
that
indicates
abundance
bioactive
pigments,
such
as
chlorophyll
and
possibly
xanthophyll.
Unlike
chlorophyll,
which
has
been
well
explored,
the
composition
carotenoids
C.
its
biological
activities
have
not
reported.
Therefore,
this
study
aims
to
look
at
carotenoid
profile
racemose
determine
their
activities,
include
antidiabetic,
anti-obesity,
anti-oxidative,
anti-inflammatory,
cytotoxicity
in
vitro.
The
detected
were
all
xanthophylls,
included
fucoxanthin,
lutein,
astaxanthin,
canthaxanthin,
zeaxanthin,
β-carotene,
β-cryptoxanthin
based
on
orbitrap-mass
spectrometry
(MS)
rapid
ultra-high
performance
liquid
chromatography
(UHPLC)
diode
array
detector.
Of
seven
observed,
should
be
highlighted
β-carotene
canthaxanthin
two
most
dominant
present
racemosa.
Interestingly,
extract
good
activity
inhibiting
α-glucosidase,
α-amylase,
DPPH
ABTS,
TNF-α
mTOR,
upregulating
AMPK,
makes
drug
candidate
or
functional
antidiabetic
food,
very
promising
anti-obesity
anti-inflammatory.
More
interestingly,
value
shows
level
safety
normal
cells,
potential
for
further
development
nutraceuticals
pharmaceuticals.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(5), P. 278 - 278
Published: April 28, 2023
Exploration
of
seaweeds
to
unravel
their
bioactive
metabolites
from
the
perspective
wider
applications
gained
substantial
importance.
The
present
study
was
performed
investigate
total
phenolic,
flavonoid,
tannin
content,
antioxidant
activity
and
antibacterial
potential
various
solvent
extracts
green
seaweed
Caulerpa
racemosa.
methanolic
extract
showed
higher
phenolic
(11.99
±
0.48
mg
gallic
acid
equivalents/g),
(18.59
0.54
tannic
equivalents/g)
flavonoid
(33.17
0.76
quercetin
content
than
other
extracts.
Antioxidant
determined
by
using
2,2-diphenylpicrylhydrazyl
(DPPH)
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
assay
with
different
concentrations
C.
racemosa
scavenging
in
both
DPPH
ABTS
inhibition
value
54.21
1.39%
76.62
1.08%,
respectively.
Bioactive
profiling
also
identified
Gas
chromatography-mass
spectrometry
(GC-MS)
Fourier
transform
infrared
(FT-IR)
techniques.
These
studies
revealed
presence
valuable
compounds
these
might
be
responsible
for
antimicrobial,
antioxidant,
anticancer
anti-mutagenic
properties.
Major
GC-MS
were
3,7,11,15-Tetramethyl-2-hexadecen-1-ol,
3-hexadecene
Phthalic
acid.
In
terms
activity,
has
promising
against
aquatic
pathogens
Aeromonas
hydrophila,
veronii
salmonicida.
Further
evaluation
focusing
related
aspects
would
reveal
novel
bioproperties
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
104, P. 105555 - 105555
Published: April 24, 2023
The
exploration
of
natural
ingredients
to
prevent
or
delay
ageing
is
fascinating
develop
in
the
industrial
technologies
nutraceuticals.
Indonesian
green
algae
(Caulerpa
racemosa
and
Caulerpa
lentillifera)
are
predicted
contain
many
bioactive
substances
that
have
not
been
studied
intensively
but
potential
be
a
source
anti-ageing.
Therefore,
this
study
examine
content
with
related
proteins
play
an
important
role
process
vitro
study.
This
reveals
novel
anti-ageing
from
two
C.
lentillifera
via
modulation
mTOR-SIRT1-AMPK
pathways
their
antioxidant
abilities.
Based
on
integration
these
silico
vitro,
candidates
for
nutraceuticals
pharmaceutical
agents,
which
supported
by
synergistic
effect
capacity
against
free
radicals
oxidative
stress.
Journal of Agriculture and Food Research,
Journal Year:
2023,
Volume and Issue:
12, P. 100621 - 100621
Published: May 13, 2023
Marine
and
terrestrial
organisms
are
rich
in
chemical
compounds
with
medicinal
pharmacological
properties,
including
antitumor
agents
for
chemoprevention.
Caulerpa
racemosa,
a
marine
species,
is
potential
source
of
novel
therapeutic
human
cancer.
This
study
aimed
to
determine
the
anticancer
activity
C.
racemosa
extracts
breast
cancer
cells,
identify
compounds,
mechanism
using
computational
models.
Seaweed
(C.
racemosa)
was
taken
from
North
Sulawesi,
Indonesia;
Followed
by
authentication
identification
according
previously
published
protocol
extracted
three
different
solvent:
hexane,
ethyl
acetate,
ethanol.
were
evaluated
cytotoxicity
against
MCF-7
cells
MTT
(3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium
bromide)
assay.
Antioxidant
activities
assessed
based
on
free
radical
scavenging
(2,2-diphenyl-1-picrylhydrazyl
(DPPH))
ferric-reducing
antioxidant
power
(FRAP)
assays.
The
phytochemical
constituents
identified
liquid
chromatography-electrospray
ionization
quadrupole
time-of-flight
mass
spectrometry
(LC-ESI-QTOF-MS)
system.
interaction
epidermal
growth
factor
2
(HER2)
protein
achieved
molecular
docking
PyRx-vina
application
protein-ligand
complex
visualization.
hexane
extract
exhibited
highest
followed
acetate
ethanol
(IC50
23.7
±
2.0;
66.7
5.8
182.7
14.3
μg/mL).
best
sample
DPPH
21.5
2.0
μg/mL)
while
most
active
FRAP
value
(14.5
1.3
μg
gallic
acid
equivalent/g).
Data
LC-ESI-QTOF-MS
allowed
21
compounds.
showed
that
12
could
prevent
tumors
acting
as
inhibitors
anti-apoptotic
HER2
protein.
has
chemoprevention
through
its
capacity
inhibition
More
studies
needed
investigate
efficacy
Future Foods,
Journal Year:
2024,
Volume and Issue:
9, P. 100354 - 100354
Published: April 23, 2024
Novel
dietary
strategies
are
urgently
needed
to
address
the
limitations
of
current
management
and
treatment
options
Type-2
Diabetes
(T2D).
Marine
algae-derived
peptides
(MAP)
represent
a
promising
avenue,
although,
their
potential
remains
mostly
underexplored.
This
study
employs
pharmacoinformatics
in
vitro
methods
evaluate
antidiabetic
properties
MAP
provide
new
insights
mechanisms
mitigate
prevalence
T2D.
Through
systematic
search
predictive
modeling,
were
identified
assessed
for
bioactivity,
toxicity,
drug-likeness.
Furthermore,
molecular
docking
simulations
with
protein
targets
related
T2D
binding
sites
that
be
used
optimize
activity
MAP.
The
structure-activity
relationship
profile
reveals
13
candidates
probable
(Pa)
scores
>0.4,
indicative
insulin
promoter.
peptide
FDGIP
(P13;Phe-Asp-Gly-Ile-Pro)
from
Caulerpa
lentillifera
had
best
silico
assessment
value
compared
50
other
its
was
confirmed
by
data
(e.g.EC50
60.4
57.9
α-amylase
α-glucosidase
inhibitions).
Interestingly,
3T3-L1
cells,
P13
exhibited
inhibitory
activities
against
transcription
factors
hormones
(MAPK8-JNK1/PPARGC1A/Ghrelin/GLP-1/CPT-1)
can
regulate
blood
sugar
decrease
as
anti-diabetes.
then
appears
action
may
formulation
foods
manage
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 22, 2025
Background
Metabolic
syndrome
(MetS)
is
a
global
health
concern,
characterized
by
combination
of
dyslipidemia,
insulin
resistance,
obesity,
and
hypertension,
significantly
increasing
the
risk
type
2
diabetes
mellitus
(T2DM)
cardiovascular
diseases.
Gut
microbiota
plays
pivotal
role
in
MetS
pathophysiology,
with
dysbiosis
exacerbating
metabolic
impairments.
Delites™,
supplement
inspired
Traditional
Chinese
Medicine,
has
shown
potential
modulating
gut
mitigating
MetS.
Objectives
This
study
aimed
to
evaluate
effects
Delites™
supplementation
on
composition
male
Sprague
Dawley
rats
fed
cholesterol-
fat-enriched
diet
(CFED).
Methods
A
randomized
preclinical
trial
was
conducted
32
divided
into
four
groups:
control-normal,
CFED,
CFED+low-dose
(54
mg/kg),
CFED+high-dose
(108
mg/kg).
Parameters
including
lipid
profiles,
enzymatic
activity,
molecular
biomarkers,
were
analyzed.
Results
improved
reduced
inflammation
(TNF-
α
),
enhanced
anti-inflammatory
markers
(IL-10),
increased
energy
metabolism
regulator
PGC-1α.
modulation
showed
beneficial
genera
(
Bifidobacterium
,
Lactobacillus
)
pathogenic
Proteus
improving
microbial
diversity.
Conclusion
effectively
mitigates
through
modulation.
These
findings
highlight
its
for
precision
medicine
approaches
combat
disorders.
Further
research
needed
explore
long-term
translational
relevance
humans.
