Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27
Published: Jan. 1, 2025
Language: Английский
Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110497 - 110497
Published: April 6, 2024
Language: Английский
Citations
11
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Citations
9
Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142916 - 142916
Published: Jan. 15, 2025
Language: Английский
Citations
1
Published: Jan. 1, 2025
Language: Английский
Citations
1
Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 31(1), P. 103878 - 103878
Published: Nov. 25, 2023
Tamarindus indica L., is widely used tree in ayurvedic medicine. Here, we aimed to understand the presence of important constituents seeds and peel Tamarind fruits their biological activities. Hence, are for further extraction process by soxhlet method (chloroform ethyl acetate solvents). Results suggest that extract (seeds) consists terpenoids (72.29 ± 0.513 mg/g), phenolic content (68.67 2.11 mg/g) flavonoids (26.36 2.03 whereas chloroform has (42.29 0.98 mg/g). Similarly, (peel) (25.96 3.20 (46.36 (62.93 0.987 Furthermore, anti-inflammation activity results revealed was found be more effective with IC50 226.14 µg/ml protein denaturation analysis 245.5 on lipoxygenase inhibition activity. Chloroform (peel seeds) shown better antioxidant using DPPH than seeds). Ethyl showed impressive potency inhibiting growth fungus, Candida albicans. Additionally, Escherichia coli Bacillus cereus. GC-MS existence diverse set phytochemicals each extract. Overall, comparative studies highlight effectiveness extracts extracts. Moreover, acetate) contains a wide range compounds (including flavonoids, isovanillic acid, fatty acids compounds) which can utilized therapeutic purpose.
Language: Английский
Citations
22
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 29, 2024
Flavonoids, a diverse group of polyphenolic compounds found in various plant-based foods, have garnered attention for their potential combating Hepatitis B Virus (HBV) infection. Flavonoids demonstrated promising anti-HBV activities by interfering with multiple stages the HBV life cycle, making them candidates novel antiviral agents. Certain plant families, such as Theaceae , Asteraceae Lamiaceae and Gentianaceae are particular interest flavonoid-rich members activities. Evidences, both vitro vivo supports flavonoids. These subsets compound exert effects through mechanisms, including inhibiting viral entry, disrupting replication, modulating transcription factors, enhancing immune response, inducing autophagy. The antioxidant properties flavonoids play crucial role oxidative stress associated Several like epigallocatechin gallate (EGCG), proanthocyanidin (PAC), hexamethoxyflavone, wogonin, baicalin shown significant potential, holding promise therapeutic Synergistic between existing therapies offer approach to enhance efficacy reduce drug resistance. Challenges, limited bioavailability, translation from preclinical studies clinical practice, understanding precise targets, need be addressed. Future research should focus on trials, combination therapies, development flavonoid derivatives improved optimizing effectiveness managing chronic infections.
Language: Английский
Citations
8
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)
Published: May 1, 2024
Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems
Language: Английский
Citations
8
Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 309 - 330
Published: June 21, 2024
Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.
Language: Английский
Citations
7
Life, Journal Year: 2023, Volume and Issue: 13(12), P. 2270 - 2270
Published: Nov. 28, 2023
Mango and its by-products have traditional medicinal uses. They contain diverse bioactive compounds offering numerous health benefits, including cardioprotective metabolic properties. This study aimed to explore the impact of mango fruit on human health, emphasizing syndrome components. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR were searched following PRISMA guidelines, COCHRANE handbook was utilized assess bias risks. In vivo in vitro studies shown several benefits by-products. For this systematic review, 13 met inclusion criteria. The collective findings indicated that utilization various forms—ranging from fresh slices puree by-products, leaf extract, powder, mangiferin—yielded many favorable effects. These encompassed enhancements glycemic control improvements plasma lipid profiles. Additionally, reduces food intake, elevates mood scores, augments physical performance during exercise, improves endothelial function, decreases incidence respiratory tract infections. Utilizing supports demand for healthier products. approach also aids environmental conservation. Furthermore, development mango-derived nanomedicines aligns with sustainable goals offers innovative solutions healthcare challenges whilst being environmentally conscious.
Language: Английский
Citations
16
Foods, Journal Year: 2023, Volume and Issue: 12(21), P. 3969 - 3969
Published: Oct. 30, 2023
Anthocyanins are natural flavonoid polyphenolic compounds widely found in fruits and vegetables. They exhibit antioxidant properties prophylactic effects the immune cardiovascular systems, confer protection against cancer, contribute to prevention of diseases. Thus, their incorporation into functional foods, pharmaceuticals, supplements, cosmetic formulations aims at promoting human well-being. This review comprehensively outlined structural attributes anthocyanins, expanding upon diverse methodologies employed for extraction production. Additionally, stability, metabolic pathways, manifold physiological functions anthocyanins were discussed. However, constrained fat solubility, susceptibility instability, restricted bioavailability collectively curtail applicability therapeutic efficacy. Consequently, a multidimensional approach was imperative, necessitating exploration innovative pathways surmount these limitations, thereby amplifying utilitarian significance furnishing pivotal support continual advancement broader application.
Language: Английский
Citations
14