Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3647 - 3647

Published: Aug. 20, 2023

The first 1000 days after birth represent a critical window for gut microbiome development, which is essential immune system maturation and overall health. undergoes major changes during this period due to shifts in diet environment. Disruptions the microbiota early life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological obesity. Maternal environmental factors pregnancy infancy shape infant microbiota. In article, we will review how maintaining healthy important long-term Furthermore, briefly include fungal colonization its effects on host function, are discussed as part ecosystem. Additionally, describe potential approaches such hydrogels enriched with prebiotics probiotics, transplantation (GMT) pregnancy, age-specific microbial ecosystem therapeutics, CRISPR therapies targeting hold advancing research development. Nevertheless, thorough evaluation their safety, effectiveness, impacts crucial prior application clinical approach. article emphasizes need continued optimize development through targeted early-life interventions.

Language: Английский

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Exploring the Microbial Landscape: Gut Dysbiosis and Therapeutic Strategies in Pancreatitis—A Narrative Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 645 - 645

Published: March 14, 2024

The gut microbiota is emerging as an important contributor to the homeostasis of human body through its involvement in nutrition and metabolism, protection against pathogens, development modulation immune system. It has therefore become research topic recent decades. Although association between intestinal dysbiosis numerous digestive pathologies been thoroughly researched, pancreatic diseases constitutes a novelty specialized literature. In years, growing evidence pointed critical pancreas regulating microbiota, well impact on physiology, which implies existence bidirectional connection known "gut-pancreas axis". theorized that any change at either these levels triggers response other component, hence leading evolution pancreatitis. However, there are not enough data determine whether underlying cause or result pancreatitis; therefore, more needed this area. purpose narrative review highlight role pathogenesis acute chronic pancreatitis, evolution, prospect employing therapeutic intervention for

Language: Английский

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Clinical Perspectives of Gut Microbiota in Patients with Chronic Kidney Disease and End-Stage Kidney Disease: Where Do We Stand?

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2480 - 2480

Published: Sept. 7, 2023

The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made lay three aspects: diagnostic, predictive, therapeutic interventions. While these show promising results reducing uremic toxins inflammation, challenges remain form of patient-specific variability, potential side effects, safety concerns. Our understanding GMs is still evolving, necessitating further research elucidate causal relationship mechanistic interactions. Personalized focusing on specific signatures could enhance patient outcomes. However, comprehensive clinical trials needed validate approaches’ safety, efficacy, feasibility.

Language: Английский

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Exploring a Complex Interplay: Kidney–Gut Axis in Pediatric Chronic Kidney Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3609 - 3609

Published: Aug. 17, 2023

The human intestinal microbiota is a highly intricate structure with crucial role in promoting health and preventing disease. It consists of diverse microbial communities that inhabit the gut contribute to essential functions such as food digestion, nutrient synthesis, immune system development. composition function are influenced by variety factors, including diet, host genetics, environmental features. In pediatric patients, particularly dynamic vulnerable disruption from endogenous exogenous factors. Recent research has focused on understanding interaction between kidneys. individuals chronic kidney disease, there often significant disturbance microbiota. This imbalance can be attributed factors like increased levels harmful toxins entering bloodstream, inflammation, oxidative stress. review looks at what known about link child’s gut–kidney axis, how dysbiosis, or an microbiome, affects treatments, both pharmaceutical non-pharmaceutical, available for this condition.

Language: Английский

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Celiac disease - a pluripathological model in pediatric practice

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.

Language: Английский

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Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity?

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still rise. The literature 21st century records excess weight found in up to 1/3 children. Both determining factors systemic effects are multiple variable. Regarding involvement potentiation cardio-vascular, pulmonary, digestive, metabolic, neuro-psychic or even dermatological diseases, information already broadly outlined. connection between underlying disease associated comorbidities seems be partially attributable oxidative stress. In addition these, light recent COVID-19 pandemic, role played by stress induction, maintenance chronic inflammation among overweight children adolescents becomes a topic interest again. Thus, this review’s purpose update general data obesity, emphasis physiopathological mechanisms that underlie it involve At same time, we briefly present latest principles pathology diagnosis management. Among will mainly emphasize impact endogenous exogenous antioxidants evolutionary course pediatric obesity. order achieve our objectives, refer most studies published specialized literature.

Language: Английский

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Oxidative Stress and Antioxidants in Pediatric Asthma’s Evolution and Management

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1331 - 1331

Published: Oct. 31, 2024

Within the pediatric population, bronchial asthma is one of most prevalent chronic respiratory system diseases. The number exacerbations, severity, and duration symptoms all have a significant impact on children's life quality. In last decades, prevention management strategies this pathology focused maintaining or even increasing pulmonary function to maximum levels in early childhood, as it has been demonstrated that functional deficits at level occurring before school age cause pathological manifestations later, adulthood. epithelium airways implicitly lung first barrier against lesions caused by pro-oxidative factors. Both oxidative antioxidative factors can be endogenous origin (produced body) exogenous (from environment diet). Good functioning antioxidant defense mechanisms from molecular tissue level, balance between anti- factors, influence occurrence compensatory epithelium, causing delay local responses stress induced inflammation (bronchial remodeling, thickening airway smooth muscles, bronchoconstriction, hyper-reactivity). These underlie pathophysiological changes asthma. Numerous studies carried out among population inclusively effectiveness antioxidants prophylaxis, slowing down preventing progression pathology. This review complements scientific articles, aiming emphasizing complexity physio-pathological pathways their importance occurrence, development, therapeutic response asthma, providing good understanding relationship being source future strategies.

Language: Английский

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The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to numerous researches aimed at its interactions with body’s homeostasis. At same time, there a peak in terms of recommendations for supplementation it. Some studies focus on link between autoimmune diseases and nutritional deficiencies, especially D3. Since specialized literature children (patients 0-18 years old) far from equal informational diversity adult-centered branch, this review aims bring up date relationship microbial balance activity pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides better understanding an adequate, individualized management affected persons reduce morbidity. center summary establish impact hypovitaminosis D development evolution erythematosus. We will address aspects related two entities played by pathophysiological cascade lupus, but also risk toxicity effects when deficiency over supplemented (hypervitaminosis D). debate modulation immune function, potentiation inflammatory processes, increase oxidative stress, perfusion cognitive brain areas, seasonal incidence SLE severity. Finally, we current knowledge, post-pandemic, regarding – pSLE relationship.

Language: Английский

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Hormonal Catalysts in the Addiction Cycle of Muscle Dysmorphia: A Neuroendocrine Perspective

The Journal of Neurobehavioral Sciences, Journal Year: 2024, Volume and Issue: 11(1), P. 1 - 9

Published: Jan. 1, 2024

Abstract Muscle dysmorphia (MD) is a subtype of body dysmorphic disorder characterized by an obsessive belief that one’s insufficiently muscular. This review provides comprehensive examination the addiction cycle in MD, particularly context anabolic steroid and performance-enhancing drug (PED) use. Utilizing systematic search across databases such as PubMed, PsycINFO, Scopus, Web Science, draws on peer-reviewed literature published past two decades to uncover roles hormonal neural alterations perpetuating this cycle. Inclusion exclusion criteria were meticulously applied ensure robust analysis relevant studies. The article details interaction between exogenous supplementation from steroids PEDs brain receptors, which significantly disrupt neurotransmitter systems affect mood, cognition, stress responses. synthesis data reveals imbalances due substance abuse lead profound changes plasticity function, instigating psychiatric disorders complicating withdrawal treatment. Therapeutic strategies are critically assessed, with emphasis success cognitive-behavioral therapy, role pharmacological management, promise emerging treatments targeting neuroendocrine disruptions. suggests integrated, holistic treatment model includes therapy neurological considerations, underscoring importance personalized sustained interventions. In conclusion, intricate fueled effects brain, calls for integrated approach Future research should focus impact these substances refine therapeutic MD.

Language: Английский

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Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.

Language: Английский

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