Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101321 - 101321
Published: Sept. 1, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 429 - 429
Published: March 30, 2024
Polyphenols, as secondary metabolites ubiquitous in plant sources, have emerged pivotal bioactive compounds with far-reaching implications for human health. Plant polyphenols exhibit direct or indirect associations biomolecules capable of modulating diverse physiological pathways. Due to their inherent abundance and structural diversity, garnered substantial attention from both the scientific clinical communities. The review begins by providing an in-depth analysis chemical intricacies polyphenols, shedding light on diversity such biological activities. Subsequently, exploration dietary origins elucidates natural plant-based sources that contribute global availability. discussion extends bioavailability metabolism within body, unraveling complex journey ingestion systemic effects. A central focus is dedicated unravelling antioxidant effects highlighting role combating oxidative stress associated health conditions. comprehensive encompasses impact concerns hypertension, allergies, aging, chronic diseases like heart stroke diabetes. Insights into beneficial further underscore potential preventive therapeutic agents. This article critically examines multifaceted aspects encompassing chemistry, origins, bioavailability/metabolism dynamics, profound synthesis information presented herein aims provide a valuable resource researchers, clinicians, enthusiasts, fostering deeper understanding intricate relationship between
Language: Английский
Citations
33
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Language: Английский
Citations
7
Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, future research directions in diabetes. A comprehensive literature search was conducted using PubMed, Medline, other medical databases identify, review, evaluate published articles on The focused studies examining pathophysiology, presentations, diagnostic approaches, strategies. current revealed that chronic hyperglycemia, insulin resistance, vascular factors are major contributing deficits Clinical manifestations include impairments attention, memory, executive function, visuospatial abilities, language. Risk encompass disease duration, glycemic control, presence complications, age, education level, comorbidities. Assessment tools screening instruments, neuropsychological testing, neuroimaging techniques. Management strategies involve control optimization, lifestyle modifications, training, pharmacological interventions. highlights prevalence impact diabetes, resulting from complex metabolic disturbances. Early detection multifaceted interventions crucial for preserving function improving patient outcomes. Future should focus neuroprotective biomarker identification, personalized approaches. Collaborative efforts between clinicians researchers essential effectively address this growing healthcare challenge enhance life individuals with diabetes-related impairment.
Language: Английский
Citations
2
Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754
Published: Jan. 1, 2025
Language: Английский
Citations
2
Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441
Published: Aug. 2, 2024
Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.
Language: Английский
Citations
12
Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 206 - 206
Published: Jan. 13, 2025
Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 203 - 203
Published: Feb. 10, 2025
The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.
Language: Английский
Citations
1
World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(7), P. 1430 - 1447
Published: July 8, 2024
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide. Recent studies indicated possible link between DM an increased risk of developing AD. Insulin, while primarily known for its role in regulating blood sugar, also plays vital protecting brain functions. Insulin resistance (IR), especially prevalent type 2 diabetes, is believed to play significant AD's development. When insulin signalling becomes dysfunctional, it can negatively affect various functions, making individuals more susceptible defining features, such as the buildup beta-amyloid plaques tau protein tangles. Emerging research suggests addressing insulin-related issues might help reduce or even reverse changes linked This review aims explore rela-tionship AD, with focus on IR. It explores molecular mechanisms by which IR lead assesses current treatments target Understanding IR's connection AD offers new possibilities highlights importance continued this interdisciplinary field.
Language: Английский
Citations
8
Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
Abstract Background and Hypothesis This review examines the evolution future prospects of prevention based on evaluation (PBE) for individuals at clinical high risk (CHR) psychosis, drawing insights from SHARP (Shanghai At Risk Psychosis) study. It aims to assess effectiveness non-pharmacological interventions in preventing psychosis onset among CHR individuals. Study Design The provides an overview developmental history study its contributions understanding needs explores limitations traditional antipsychotic approaches introduces PBE as a promising framework intervention. Results Three key implemented by team are discussed: nutritional supplementation niacin skin response blunting, precision transcranial magnetic stimulation targeting cognitive brain functional abnormalities, behavioral therapy psychotic symptoms addressing symptomatology impaired insight characteristics. Each intervention is evaluated within context PBE, emphasizing potential tailored Conclusions highlights strengths applications discussed interventions, underscoring their revolutionize preventive care also into directions populations, including efforts expand techniques enhance interventions.
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: May 16, 2024
Background It is well known that metabolic disorders, including type 1 diabetes (T1D), are often associated with reduced male fertility, mainly increasing oxidative stress and impairing the hypothalamus–pituitary–testis (HPT) axis, consequently altered spermatogenesis sperm parameters. Herein, using a rat model of T1D obtained by treatment streptozotocin (STZ), we analyzed several parameters testicular activity. Methods A total 10 adult Wistar rats were divided into two groups five: control T1D, single intraperitoneal injection STZ. After 3 months, anesthetized sacrificed; one testis was stored at -80°C for biochemical analysis, other fixed histological immunofluorescence analysis. Results The data confirmed induced and, consequently, alterations in both somatic germ cells. This aspect highlighted enhanced apoptosis, steroidogenesis Leydig cell maturity, impaired spermatogenesis. In addition, blood–testis barrier integrity compromised, as shown levels structural proteins (N-cadherin, ZO-1, occludin, connexin 43, VANGL2) phosphorylation status regulative kinases (Src FAK). Mechanistically, dysregulation SIRT1/NRF2/MAPKs signaling pathways proven, particularly nuclear translocation NRF2, affecting its ability to induce transcription genes encoding antioxidant enzymes. Finally, stimulation inflammation pyroptosis also confirmed, increased some markers, such NF-κB NLRP3. Conclusion combined allowed us confirm has detrimental effects on Moreover, better comprehension molecular mechanisms underlying association between disorders fertility could help identify novel targets prevent treat related T1D.
Language: Английский
Citations
4