A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(10), P. 1562 - 1590

Published: July 18, 2023

The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which caused havoc on medical infrastructures, economies, and cultures around the world. Determining whole scenario is essential since variants sub-variants keep appearing after vaccinations booster doses. objective this secondary meta-analysis to analysis co-infection, infections, antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases conduct systematic review an overlap evaluate pooled estimates co-infections infections. summary showed overall co-infection effect 26.19% (95% confidence intervals CI: 21.39 31.01, I2=98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection 11.13% 9.7 12.56, I2=99.14, 11 for bacteria; 9.69% 1.21 7.90, I2 =98.33) fungal 3.48% 2.15 4.81, =95.84) viruses. infection 19.03% 9.53 28.54, =85.65) was from 2 meta-analyses (Ave: 82 primary studies). first that compiles results all previous three years into single source offers strong proof infections Early detection AMR crucial order effectively effective treatment.

Language: Английский

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Cladosporium species novum Invasive Pulmonary Infection in a Patient with Post-COVID-19 Syndrome and AIDS

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 781 - 781

Published: March 20, 2025

Background and Clinical Significance: Since the prevalence of fungal lung infections is increasing, certain agents, such as Cladosporium spp., have emerged unexpected causes. spp. fungi are ubiquitous in environments soil, fruits, wine corks; they a part normal human skin flora; known respiratory allergens. Case Presentation: A patient with history post-COVID-19 syndrome AIDS presented pathology indicative an invasive infection. The initial histopathological examination revealed numerous yeast-like cells narrow-based budding, which led to mistaken diagnosis cryptococcosis. However, further detailed sparse hyphae tissue, suggesting more complex Molecular analyses sequence BLAST alignment were performed, ultimately identifying infectious agent “Cladosporium species novum”, rare cause pulmonary cladosporiasis. Conclusions: Invasive cladosporiasis condition, morphological features fungus alone insufficient establish correct diagnosis. comprehensive pathohistological molecular approach bioinformatics tools essential for identification potentially life-threatening pathogens immunocompromised patients.

Language: Английский

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Practical considerations in the use of deceased bodies for biomedical research and education

Medico-Legal Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

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Fungal infections in patients after recovering from COVID-19: a systematic review

Therapeutic Advances in Infectious Disease, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Background and aims: The presence of fungal infections has been described in patients after recovering from COVID-19. This study aims to conduct a systematic review studies that reported ( Mucor spp., Pneumocystis jirovecii, or Aspergillus spp.) adults Methods: We performed through PubMed, Web Science, OVID-Medline, Embase, Scopus. selection process was independently by at least two authors. risk bias assessment using the Newcastle–Ottawa Scale for cohort case–control studies, Joanna Briggs Institute’s Checklists Case Series Reports. Results: search found 33 meeting all inclusion criteria. There total population 774 participants, ranging 21 87 years. From them, 746 developed infection. In 19 spp. as main mycosis. 10 P. jirovecii seven Regarding quality assessment, 12 were classified low remaining high bias. Conclusion: Patients’ clinical presentation prognosis COVID-19 with infection differ those acute without

Language: Английский

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Community-acquired bacterial coinfections and COVID-19

Physiological Reviews, Journal Year: 2023, Volume and Issue: 104(1), P. 1 - 21

Published: Aug. 17, 2023

Language: Английский

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COVID-19 associated mucormycosis: A bibliometric analysis of Indian research based on Scopus

Iberoamerican Journal of Science Measurement and Communication, Journal Year: 2023, Volume and Issue: 3(2)

Published: Sept. 20, 2023

Objective. Invasive fungal infections, specifically mucormycosis, showed a massive surge during the COVID-19 pandemic, forcing global medical fraternity to research this highly fatal co-infection. India has contributed significantly COVID-19-associated mucormycosis (CAM) research, but bibliometric analysis of topic is scarce. Using established methods, we aimed provide yield and impact CAM in India. Design/Methodology/Approach. The publication data on was extracted from Scopus. Data analyzed using quality indices such as citations per paper (CPP), relative citation index (RCI), total linkage strength (TLS). Results/Discussion. 640 (61.2%) 1045 publications involving 548 authors 247 organizations. Only 62 (9.8%) 96 (15.0%) were funded collaborative. focused clinical features (36.5%), complications (21.7%), risk factors (19.2%), epidemiology (12.3%), diagnostics & imaging (6.8%), treatment outcomes (4.5%), prognosis (3.4%) pathophysiology (3.1%). average CPP Indian 7.8 compared 28.2 France, 17.8 USA, 8.7 Saudi Arabia, 8.3 Bangladesh, 8.1 Iran. major collaborations with UK, Pakistan, Malaysia, UAE. most productive organizations PGIMER-Chandigarh (n=47), AIIMS-New Delhi (n=44), AIIIMS-Jodhpur (n=17), whereas impactful SMS Medical College, Jaipur, SGPGIMS, Lucknow BJ Ahmedabad. A. Chakrabarti, V. Muthu, R. Agarwal, I.S. Sehgal, Muthu. preferred journals Journal Ophthalmology, Otolaryngology Head Neck Surgery, BMJ Case Reports. Conclusions. Even though topmost contributor its lower than those France USA. largely non-funded. There need improve international collaboration increase focus pathophysiology, epidemiology, pediatric aspects. This may lead an improved understanding survival affected patients.

Language: Английский

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Excess burden of respiratory and abdominal conditions following COVID-19 infections during the ancestral and Delta variant periods in the United States: An EHR-based cohort study from the RECOVER program

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0282451 - e0282451

Published: June 6, 2024

Importance The frequency and characteristics of post-acute sequelae SARS-CoV-2 infection (PASC) may vary by variant. Objective To characterize PASC-related conditions among individuals likely infected the ancestral strain in 2020 Delta variant 2021. Design Retrospective cohort study electronic medical record data for approximately 27 million patients from March 1, 2020-November 30, Setting Healthcare facilities New York Florida. Participants Patients who were at least 20 years old had diagnosis codes that included one viral test during period. Exposure Laboratory-confirmed COVID-19 infection, classified most common prevalent those regions time. Main outcome(s) measure(s) Relative risk (estimated adjusted hazard ratio [aHR]) absolute difference excess burden) new conditions, defined as documentation symptoms or diagnoses, persons between 31–180 days after a positive compared to without last negative test. Results We analyzed 560,752 patients. median age was 57 years; 60.3% female, 20.0% non-Hispanic Black, 19.6% Hispanic. During period, 57,616 test; 503,136 did not. For infections pulmonary fibrosis, edema (excess fluid), inflammation largest aHR, comparing with (aHR 2.32 [95% CI 2.09 2.57]), dyspnea (shortness breath) carried burden (47.6 more cases per 1,000 persons). embolism aHR 2.18 1.57, 3.01]), abdominal pain (85.3 Conclusions relevance documented substantial relative large abdomen-related As variants emerge, researchers clinicians should monitor changing develop infection.

Language: Английский

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Analyzing Co-Infection Dynamics: A Mathematical Approach Using Fractional Order Modeling and Laplace-Adomian Decomposition

Journal of Biosafety and Biosecurity, Journal Year: 2024, Volume and Issue: 6(2), P. 113 - 124

Published: May 17, 2024

The co-infection of HIV and COVID-19 is a pressing health concern, carrying substantial potential consequences. This study focuses on the vital task comprehending dynamics HIV-COVID-19 co-infection, fundamental step in formulating efficacious control strategies optimizing healthcare approaches. Here, we introduce an innovative mathematical model grounded Caputo fractional order differential equations, specifically designed to encapsulate intricate co-infection. encompasses multiple critical facets: transmission both COVID-19, host's immune responses, influence treatment interventions. Our approach embraces complexity these factors offer exhaustive portrayal dynamics. To tackle model, employ Laplace-Adomian decomposition method, potent tool for approximating solutions equations. Utilizing this technique, simulate interactions between variables, yielding profound insights into propagation Notably, identify pivotal contributors its advancement. In addition, conduct meticulous analysis convergence properties inherent series acquired through method. examination assures reliability accuracy our methodology solutions. findings hold significant implications formulation effective strategies. Policymakers, professionals, public authorities will benefit from research as they endeavor curtail proliferation impact

Language: Английский

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Quality improvement in neonatal care through enhanced patient safety and clinical risk management: a before-and-after study about neonatal sepsis

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 20, 2024

Introduction Neonatal sepsis, classified into early-onset and late-onset based on symptom timing, poses significant risks of morbidity mortality, especially in low birth weight infants. Effective clinical risk management protocols are crucial reducing these risks. Methods This before-and-after study evaluated the impact a newly implemented protocol Neonatology Intensive Care Unit (NICU) at Policlinico Hospital-University Bari. The included 399 neonates over three years, comparing pre- post-protocol outcomes. Data collection focused maternal neonatal demographics, infection rates, hospital stay lengths. Statistical analysis t -tests, Wilcoxon-Mann–Whitney tests, logistic regression models. Results found no differences pathologies or demographics between groups. However, implementation showed notable reduction umbilical venous catheter (UVC) infections ( p = 0.018) improved Blood urine cultures did not show changes microbial patterns post-protocol. Discussion findings underscore effectiveness structured enhancing outcomes, particularly specific Despite study’s limitations, including its observational nature sample size, results advocate for broader adoption further research diverse healthcare settings. positive outcomes highlight importance continuous efforts high-risk environments.

Language: Английский

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Nosocomial Bacterial Bronchopneumonia and SARS-CoV-2 Pneumonia in Patients with Traumatic Injuries: Imaging Aspects and Macroscopic and Microscopic Findings of Lung Tissue

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2737 - 2737

Published: Dec. 5, 2024

Patients with traumatic injuries often represent the best hosts for healthcare-associated infections, especially pneumonia or bronchopneumonia. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic raised serious problems in diagnosis and treatment of patients that had a SARS-CoV-2 infection associated nosocomial bacterial In forensic medicine, these aspects need to be considered when establishing cause death distinction between two types bronchopneumonia is particular importance.

Language: Английский

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