Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1985 - 1985
Published: July 20, 2023
The
present
study
investigates
the
brain-targeted
efficiency
of
atomoxetine
(AXT)-loaded
nanostructured
lipid
carrier
(NLC)-laden
thermosensitive
in
situ
gel
after
intranasal
administration.
AXT-NLC
was
prepared
by
melt
emulsification
ultrasonication
method
and
optimized
using
Box–Behnken
design
(BBD).
formulation
(AXT-NLC)
exhibited
particle
size
PDI,
zeta
potential,
entrapment
(EE)
108
nm,
0.271,
−42.3
mV,
84.12%,
respectively.
morphology
found
to
be
spherical,
as
confirmed
SEM
analysis.
DSC
results
displayed
that
AXT
encapsulated
within
NLC
matrix.
Further,
(AXT-NLC13)
incorporated
into
a
poloxamer
407
carbopol
gelling
agent
evaluated
for
different
parameters.
(AXT-NLC13G4)
showed
excellent
viscosity
(2532
±
18
Cps)
at
37
°C
formed
28–34
°C.
AXT-NLC13-G4
sustained
release
(92.89
3.98%
12
h)
compared
pure
(95.47
2.76%
4
h).
permeation
flux
through
goat
nasal
mucosa
from
504.37
µg/cm2·h
232.41
µg/cm2·h,
intranasally
significantly
higher
absolute
bioavailability
(1.59-fold
higher)
than
intravenous
51.91%
BTP
(28.64%)
when
administered
via
same
route
(intranasally).
BTE
(207.92%)
(140.14%)
intranasally,
confirming
high
amount
reached
brain.
With
disrupted
performance
induced
L-methionine,
(p
<
0.05)
better
activity
well
donepezil
(standard).
finding
concluded
is
novel
improvement
brain
delivery
requires
further
investigation
more
justification.
Expert Opinion on Drug Delivery,
Journal Year:
2023,
Volume and Issue:
20(12), P. 1731 - 1748
Published: Oct. 31, 2023
The
nose-to-brain
route
has
been
widely
investigated
to
improve
drug
targeting
the
central
nervous
system
(CNS),
where
lipid
nanoparticles
(solid
-
SLN
and
nanostructured
carriers
NLC)
seem
promising,
although
they
should
meet
specific
criteria
of
particle
size
(PS)
<200
nm,
polydispersity
index
(PDI)
<0.3,
zeta
potential
(ZP)
~|20|
mV
encapsulation
efficiency
(EE)
>80%.
To
optimize
NLC
formulations,
design
experiment
(DoE)
recommended
as
a
quality
by
(QbD)
tool.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
664, P. 124631 - 124631
Published: Aug. 29, 2024
Epilepsy
is
a
highly
prevalent
neurological
disease
and
valproic
acid
(VPA)
used
as
first-line
chronic
treatment.
However,
this
drug
has
poor
oral
bioavailability,
which
requires
the
administration
of
high
doses,
resulting
in
adverse
effects.
Alternative
routes
VPA
have
therefore
been
investigated,
such
nose-to-brain
route,
allows
to
be
transported
directly
from
nasal
cavity
brain.
Here,
use
nanostructured
lipid
carriers
(NLC)
encapsulate
drugs
administered
proved
advantageous.
The
aim
work
was
optimise
mucoadhesive
formulation
VPA-loaded
NLC
for
intranasal
improve
treatment
epilepsy.
Design
Experiment
(DoE)
formulation,
starting
with
component
optimisation
using
Mixture
(MD),
followed
by
manufacturing
process
parameters
Central
Composite
(CCD).
optimised
had
particle
size
76.1
±
2.8
nm,
polydispersity
index
0.190
0.027,
zeta
potential
28.1
2.0
mV
an
encapsulation
efficiency
85.4
0.8%.
vitro
release
study
showed
50
%
after
6
h
100
24
h.
biocompatibility
experiments
various
cell
lines
shown
that
safe
up
75
µg/mL,
neuronal
(SH-SY5Y),
(RPMI
2650)
hepatic
(HepG2)
cells.
Finally,
interaction
mucus
investigated
properties
were
observed.
results
suggest
may
promising
alternative
promote
targeting
brain,
thereby
improving
bioavailability
minimising
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 290 - 290
Published: Feb. 20, 2025
Objectives:
This
study
aimed
to
develop
hesperidin
solid
lipid
nanoparticles
(HESP-SLNs)
enhance
their
stability,
solubility,
and
sustained
release
for
wound
healing;
further
enhancement
was
achieved
through
prepared
nanostructured
carriers
(HESP-NLCs)
using
Tea
Tree
Oil
(TTO)
explore
synergistic
efficacy.
Methods:
A
factorial
design
of
24
trials
established
evaluate
the
influence
type
(X1),
conc
(%)
(X2),
surfactant
(X3),
sonication
amplitude
(X4)
HESP-SLNs
on
particle
size
(nm)
(Y1),
polydispersibility
index
(Y2),
zeta
potential
(Y3),
encapsulation
efficiency
(Y4).
The
optimized
formula
selected
utilizing
Design
Expert®
software
version
13,
which
additionally
enhanced
by
preparing
TTO-loaded
HESP-NLCs.
In
vitro
release,
Raman
spectroscopy,
transmission
electron
microscopy
were
carried
out
both
nanoparticles.
Cytotoxicity,
in
vivo
wound-healing
assessments,
skin
irritancy
tests
performed
performance
TTO-incorporated
HESP-NLCs
compared
HESP-SLNs.
Results:
demonstrated
PS
(280
±
1.35
nm),
ZP
(−39.4
0.92
mV),
PDI
(0.239
0.012),
EE%
(88.2
2.09%).
NLCs
Q6%
(95.14%)
vs.
(79.69%),
SLNs
showed
superior
antimicrobial
Both
exhibited
spherical
morphology
compatibility
between
HESP
excipients.
highest
closure
percentage,
supported
histological
analysis
inflammatory
biomarker
outcomes.
Cytotoxicity
evaluation
87%
cell
viability
untreated
HSF
cells,
test
confirmed
safety
NLCs.
Conclusions:
are
promising
candidates
exhibiting
capabilities,
making
them
a
therapeutic
option
cutaneous
management.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6590 - 6590
Published: April 1, 2023
Intranasal
drug
delivery
is
convenient
and
provides
a
high
bioavailability
but
requires
the
use
of
mucoadhesive
nanocarriers.
Chitosan
well-established
polymer
for
applications
can
suffer
from
poor
cytocompatibility
stability
upon
administration.
In
this
work,
we
present
method
to
obtain
stable
cytocompatible
crosslinked
chitosan
nanoparticles.
We
used
2,6-pyridinedicarboxylic
acid
as
biocompatible
crosslinker
compared
obtained
particles
with
those
prepared
by
ionotropic
gelation
using
sodium
tripolyphosphate.
Nanoparticles
were
tested
evaluate
size
surface
charge,
well
their
in
storage
conditions
(4
°C),
at
nasal
cavity
temperature
(32
body
(37
°C).
The
nanoparticles
showed
around
150
nm
charge
10.3
mV
±
0.9
mV,
both
compatible
intranasal
Size
parameters
did
not
significantly
vary
over
time,
indicating
good
these
finally
vitro
SHSY5Y
human
neuroblastoma
RPMI
2650
epithelial
cells,
positive
results.
conclusion,
proposed
synthetic
system
shows
an
interesting
potential
carrier
delivery.
Gels,
Journal Year:
2023,
Volume and Issue:
9(8), P. 640 - 640
Published: Aug. 8, 2023
Smart
and
intelligent
xanthan
gum/pluronic
F-127
hydrogels
were
fabricated
for
the
controlled
delivery
of
atomoxetine
HCl.
Different
parameters
such
as
DSC,
TGA,
FTIR,
XRD,
SEM,
drug
loading,
porosity,
swelling
index,
release,
kinetics
modeling
appraised
prepared
matrices
hydrogels.
FTIR
confirmed
successful
synthesis
hydrogel,
while
TGA
DSC
analysis
indicated
that
thermal
stability
reagents
was
improved
after
polymerization
technique.
SEM
revealed
hard
surface
XRD
a
reduction
in
crystallinity
reagents.
High
gel
fraction
achieved
with
high
incorporated
contents
polymers
monomer.
An
increase
swelling,
release
observed
concentrations
gum
acrylic
acid,
whereas
Pluronic
showed
opposite
effect.
A
negligible
index
shown
at
pH
1.2
4.6
greater
7.4,
indicating
pH-responsive
nature
designed
Furthermore,
higher
found
7.4
compared
to
4.6,
respectively.
The
first
order
followed
by
hydrogel
formulations.
Thus,
it
is
signified
from
discussion
smart
have
potential
control
HCl
colon
an
extended
period
time.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(2), P. 834 - 860
Published: Feb. 5, 2024
Lipids
originate
from
plant
and
animal
sources
have
significant
roles
in
various
fields,
like
pharmaceuticals,
cosmetics,
food,
paint,
leather,
agriculture,
microfluidics,
oil
industries.
Over
the
years,
with
development
of
technology,
different
types
lipids
been
synthesized
or
extracted
used
based
on
their
industrial
need.
are
heterogeneous
group
compounds
related
to
fatty
acids
insoluble
water
but
soluble
organic
solvents.
One
category
great
importance
is
solid
lipids.
Solid
a
type
that
remain
at
ambient
temperature.
In
past,
were
obtained
natural
they
mainly
as
bulking
agents
bases
for
dosage
forms.
due
course
time,
after
industrialization,
evolved
gained
more
significance.
drug
targeting
controlled
delivery
release
rate
modifiers,
solubilizers,
stabilizers,
permeation
enhancers
improved
biopharmaceutical
performance
drugs.
These
also
popular
diversified
applications
industries
mentioned
above.
this
review,
authors
selected
some
Stearic
acid,
Compritol®ATO
888,
Precirol®ATO
5,
Glyceryl
Monostearate,
Witepsol®,
Carnauba
wax,
Softisan®,
Cholesterol,
Dynasan®,
Cetyl
palmitate
discussed
about
properties
applications.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12343 - 12368
Published: Nov. 1, 2024
The
intranasal
(IN)
route
of
drug
delivery
can
effectively
penetrate
the
blood-brain
barrier
and
deliver
drugs
directly
to
brain
for
treatment
central
nervous
system
(CNS)
disorders
via
intra-neuronal
or
extra-neuronal
pathways.
This
approach
has
several
advantages,
including
avoidance
first-pass
metabolism,
high
bioavailability,
ease
administration,
improved
patient
compliance.
In
recent
years,
an
increasing
number
studies
have
been
conducted
using
encapsulated
in
solid
lipid
nanoparticles
(SLNs)
nanostructured
carriers
(NLCs),
delivering
them
IN
pathway.
SLNs
are
first-generation
nanocarriers,
known
their
excellent
biocompatibility,
drug-loading
capacity,
remarkable
stability.
NLCs,
regarded
as
second-generation
SLNs,
not
only
retain
advantages
but
also
exhibit
enhanced
stability,
preventing
leakage
during
storage.
this
review,
we
examined
vivo
between
2019
2024
that
used
NLCs
address
CNS
route.
By
statistical
methods
evaluate
pharmacokinetic
parameters,
found
markedly
accumulation
targeting
within
brain.
Additionally,
pharmacodynamic
evaluations
indicated
method
substantially
therapeutic
effectiveness
alleviating
symptoms
rat
models
diseases.
addition,
enhancing
efficacy
nose-to-brain
discussed,
well
advances
clinical
trials
regarding
NLCs.
PubMed,
Journal Year:
2024,
Volume and Issue:
27(7), P. 904 - 913
Published: Jan. 1, 2024
"Quality
by
Design"
(QbD)
is
a
novel
approach
to
product
development
that
involves
understanding
the
and
process,
as
well
relationship
between
critical
quality
attributes
(CQA)
process
parameters
(CPP).
This
study
aimed
optimize
gabapentin-loaded
solid
lipid
nanoparticle
formulation
(GP-SLN)
using
QbD
evaluate
in
vitro
ex
vivo
performance.
Vertex Revista Argentina de Psiquiatría,
Journal Year:
2024,
Volume and Issue:
35(165), P. 67 - 73
Published: Oct. 20, 2024
El
trastorno
por
déficit
de
atención/hiperactividad
(TDAH)
es
un
del
neurodesarrollo
caracterizado
niveles
problemáticos
inatención,
desorganización
y/o
hiperactividad-impulsividad.
Afecta
diversos
campos
la
vida
paciente
como
conducta
y
su
desenvolvimiento
social
académico.
TDAH
tiene
una
etiología
multifactorial,
con
implicaciones
genéticas,
ambientales,
socioeconómicas,
entre
otras.
Es
principalmente
diagnosticado
en
niños;
sin
embargo,
puede
permanecer
hasta
edad
adulta
o
bien,
ser
haber
pasado
desapercibido
durante
niñez.
Existe
posibilidad
que
los
síntomas
sean
compensados
al
llegar
a
adultez
no
producir
dificultades,
pero
cuando
hay
alteraciones
ambientales
comorbilidades,
pueden
evidentes,
se
enfrenta
estrés
escolar,
laboral
dado
las
cargas
trabajo
universidad
exigente.
