Technological advances in three-dimensional skin tissue engineering

REVIEWS ON ADVANCED MATERIALS SCIENCE, Journal Year: 2023, Volume and Issue: 62(1)

Published: Jan. 1, 2023

Abstract Tissue engineering is an enabling technology that can be used to repair, replace, and regenerate different types of biological tissues holds great potential in various biomedical applications. As the first line defense for human body, skin has a complex structure. When injured by trauma or disease, may under natural conditions, though often resulting irreversible aesthetically unpleasant scarring. The development tissue strategies was reviewed. Although traditional approaches have made good progress, they are still unable effectively deal with large-area injuries produce full-thickness grafts. In vitro three-dimensional (3D) constructs equivalent substitutes promoted many major innovative discoveries biology medicine. 3D manufacturing divided into two categories: scaffold-free scaffold-based. representatives transwell/Boyden chamber approach organotypic culture. Because its low cost high repeatability, model currently commonly cytotoxicity analysis, cell biochemical high-throughput function. At present, drug experiments use artificial developed replace animal models. bioprinting scaffold-based approach. novel technology, it quickly design build multi-functional model. This offers new opportunities organs layer layer, now regenerative medicine meet increasing need suitable transplantation. generate improved quality complexity wound healing disease modeling. this review, we analyze conventional techniques engineer compare them bioprinting. We also summarized equipment, bioinks, scaffolds engineering. these culture techniques, focus on technology. While maturing improvements protocols required, promise skin-related

Language: Английский

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Biodegradable Polymers for 3D Printing of Tissue Engineering Scaffolds: Challenges and Future Directions

˜The œminerals, metals & materials series, Journal Year: 2024, Volume and Issue: unknown, P. 469 - 483

Published: Jan. 1, 2024

Language: Английский

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Polymeric nanomaterials in 3D bioprinting for tissue engineering and drug delivery applications

Bioprinting, Journal Year: 2024, Volume and Issue: 40, P. e00345 - e00345

Published: May 8, 2024

Language: Английский

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Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1638 - 1638

Published: Oct. 1, 2024

The 3D bioprinting technique has made enormous progress in tissue engineering, regenerative medicine and research into diseases such as cancer. Apart from individual cells, a collection of organoids, can be printed combination with various hydrogels. It hypothesized that will even become promising tool for mechanobiological analyses organoids their matrix environments highly defined precisely structured environments, which the mechanical properties cell environment individually adjusted. Mechanical obstacles or bead markers integrated bioprinted samples to analyze deformations forces within these constructs, perform biophysical analysis complex systems, are still not standard techniques. review highlights advances 4D printing technologies integrating cues so next step detailed key future directions organoid generation development disease model regeneration drug testing perspective. Finally, hydrogels, pure natural synthetic hydrogels mixtures, organoid–cell co-cultures, organ-on-a-chip systems organoid-organ-on-a chip combinations introduces use assembloids determine mutual interactions different types cell–matrix interferences specific biological environments.

Language: Английский

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Advances in electrospinning and 3D bioprinting strategies to enhance functional regeneration of skeletal muscle tissue

Biomaterials Advances, Journal Year: 2022, Volume and Issue: 142, P. 213135 - 213135

Published: Sept. 29, 2022

Language: Английский

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