Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 188 - 188
Published: Jan. 13, 2024
The
growing
interest
in
graphene
oxide
(GO)
for
different
biomedical
applications
requires
thoroughly
examining
its
safety.
Therefore,
there
is
an
urgent
need
reliable
data
on
how
GO
nanoparticles
affect
healthy
cells
and
organs.
In
the
current
work,
we
adopted
a
comprehensive
approach
to
assess
influence
of
polyethylene
glycol-modified
form
(GO-PEG)
under
near-infrared
(NIR)
exposure
several
biological
aspects.
We
evaluated
contractility
isolated
frog
hearts,
activity
two
rat
liver
enzymes–mitochondrial
ATPase
diamine
oxidase
(DAO),
production
reactive
oxygen
species
(ROS)
C2C12
skeletal
muscle
following
direct
nanoparticles.
aim
was
study
at
multiple
levels—organ;
cellular;
subcellular—to
provide
broader
understanding
their
effects.
Our
demonstrated
that
GO-PEG
negatively
heart
frogs,
inducing
stronger
arrhythmic
contractions.
They
increased
ROS
myoblasts,
whose
effects
diminished
after
NIR
irradiation.
Both
significantly
stimulated
DAO
activity,
with
amplification
this
effect
did
not
uncouple
intact
mitochondria
but
caused
concentration-dependent
decline
freeze/thaw
mitochondria.
This
multifaceted
investigation
provides
crucial
insights
into
GOs
potential
diverse
implications
systems.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(20), P. 4785 - 4808
Published: Jan. 1, 2024
This
review
focuses
on
the
versatile
applications
of
near-infrared
(NIR)-responsive
smart
carriers
in
biomedical
applications,
particularly
drug
delivery
and
photothermal
chemotherapy.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1098 - 1098
Published: April 15, 2024
In
the
last
decade,
photothermal
therapy
(PTT)
has
attracted
tremendous
attention
because
it
is
non-invasive,
shows
high
efficiency
and
antibacterial
activity,
minimizes
drug
side
effects.
Previous
studies
demonstrated
that
PTT
can
effectively
inhibit
growth
of
bacteria
promotes
cell
proliferation,
accelerating
wound
healing
tissue
regeneration.
Among
different
NIR-responsive
biomaterials,
graphene-based
hydrogels
with
properties
are
considered
as
best
candidates
for
biomedical
applications,
due
to
their
excellent
properties.
This
review
summarizes
current
advances
in
development
innovative
PTT-based
applications.
Also,
information
about
potential
applications
therapies
provided.
These
findings
provide
a
great
supporting
biomedicine.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3973 - 3989
Published: May 1, 2024
Graphene
and
graphene-based
materials
have
attracted
growing
interest
for
potential
applications
in
medicine
because
of
their
good
biocompatibility,
cargo
capability
possible
surface
functionalizations.In
parallel,
prototypic
devices
been
developed
to
diagnose,
imaging
track
tumor
growth
cancer
patients.There
is
a
number
reports
on
the
use
graphene
its
functionalized
derivatives
design
innovative
drugs
delivery
systems,
photothermal
photodynamic
therapy,
as
platform
combine
multiple
therapies.The
aim
this
review
introduce
latest
scientific
achievements
field
composite
potentially
applied
therapy.The
"Technology
Innovation
Roadmap"
published
Flagship
indicates,
that
first
anti-cancer
using
graphenederived
will
appeared
market
by
2030.However,
it
necessary
broaden
understanding
material
interactions
with
cellular
metabolism
signaling
at
functional
level,
well
toxicity.The
main
aspects
further
research
should
elucidate
how
treatment
methods
(e.g.,
combination
therapy)
physicochemical
properties
influence
ability
modulate
autophagy
kill
cells.Interestingly,
recent
also
prove
nanocomposites
cell
death
inducing
precise
dysfunctions
caused
lysosome
damage.It
turns
out
developing
oncological
treatments,
be
taken
into
account
near-infrared-II
radiation
(1000-1500
nm)
better
option
than
NIR-I
(750-1000
can
penetrate
deeper
tissues
due
less
scattering
longer
wavelengths
radiation.
Materials Advances,
Journal Year:
2024,
Volume and Issue:
5(13), P. 5482 - 5493
Published: Jan. 1, 2024
We
construct
a
simple,
biocompatible,
sequential
catalytic
nanocatalyst
PMO@GO-GOD
to
realize
enhanced
chemodynamic
therapy
and
photothermal
for
combating
breast
cancers
by
taking
advantage
of
the
peroxidase-like
activity
GO.
