Conductive and Thermo-Responsive Composite Hydrogels with Poly(N-isopropylacrylamide) and Carbon Nanotubes Fabricated by Two-Step Photopolymerization DOI Open Access
Gianluca Ciarleglio, Elisa Toto, M. Gabriella Santonicola

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 1022 - 1022

Published: Feb. 18, 2023

Biocompatible and conductive polymer hydrogels are the subject of intensive research in bioengineering field because their use bioelectronic devices for fabrication electro-responsive tissues drug delivery systems. In this study, we report synthesis composite consisting a poly(N-isopropylacrylamide) (PNIPAM) matrix embedding carboxyl-functionalized multi-walled carbon nanotubes (MWCNT-COOH) using two-step photopolymerization method. Thermo-responsive with controlled hydrophilicity conductivity were prepared by varying nanotube concentration range 0.5–3 wt%. The thermal response PNIPAM-based was measured differential scanning calorimetry both ultrapure water PBS solution as swelling liquid. Results show that endothermic peak associated temperature-induced volume phase transition (VPT) shifts to higher temperatures upon increasing nanotubes, indicating more energy is required dissociate hydrogen bonds polymer/filler network. solution, ratios VPT reduced salt-induced screening oppositely charged assembly, electrical resistivity decreases factor 10 respect water-swollen hydrogels.

Language: Английский

Chitosan hydrogels in 3D printing for biomedical applications DOI
Mina Rajabi, Michelle McConnell, Jaydee D. Cabral

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 260, P. 117768 - 117768

Published: Feb. 10, 2021

Language: Английский

Citations

290
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays DOI Creative Commons
Zahra Faraji Rad, Philip D. Prewett,

Graham J. Davies

et al.

Microsystems & Nanoengineering, Journal Year: 2021, Volume and Issue: 7(1)

Published: Sept. 3, 2021

Abstract Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are manufactured using a variety of additive subtractive micromanufacturing techniques. In decade, attention has been paid to manufacturing techniques both research industry, such 3D printing, fused deposition modeling, inkjet two-photon polymerization (2PP), with 2PP being most flexible method fabrication microneedle arrays. is one versatile precise processes, which enables arbitrary three-dimensional (3D) prototypes directly from computer-aided-design (CAD) models resolution down 100 nm. Due its unprecedented flexibility high spatial resolution, use this technology widespread bio-microdevices bio-nanodevices microneedles microfluidic devices. This pioneering transformative that facilitates complex miniaturized structures cannot be fabricated established multistep methods injection molding, photolithography, etching. Thus, microstructures designed according structural dynamics considerations rather than constraints imposed by machining etching processes. article presents fundamentals recent development array through unique manufacture microstructures, may overcome shortcomings conventional

Language: Английский

Citations

181
Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review DOI Creative Commons
Preethi Lakkala, Siva Ram Munnangi,

Suresh Bandari

et al.

International Journal of Pharmaceutics X, Journal Year: 2023, Volume and Issue: 5, P. 100159 - 100159

Published: Jan. 3, 2023

Three-dimensional (3D) printing or Additive Manufacturing (AM) technology is an innovative tool with great potential and diverse applications in various fields. As 3D has been burgeoning recent times, a tremendous transformation can be envisaged medical care, especially the manufacturing procedures leading to personalized medicine. Stereolithography (SLA), vat-photopolymerization technique, that uses laser beam, known for its ability fabricate complex structures ranging from micron-size needles life-size organs, because of high resolution, precision, accuracy, speed. This review presents glimpse varied techniques, mainly expounding SLA terms materials used, orientation printing, working mechanisms. The previous works focused on developing pharmaceutical dosage forms, drug-eluting devices, tissue scaffolds are presented this paper, followed by challenges associated industrial regulatory perspective. Due excellent advantages, could transform conventional "one dose fits all" concept bring digitalized patient-centric medication into reality.

Language: Английский

Citations

160
Current and emerging trends in polymeric 3D printed microfluidic devices DOI
Gustavo González, Ignazio Roppolo, Candido Fabrizio Pirri

et al.

Additive manufacturing, Journal Year: 2022, Volume and Issue: 55, P. 102867 - 102867

Published: May 5, 2022

Language: Английский

Citations

123
Recent Trends in Advanced Photoinitiators for Vat Photopolymerization 3D Printing DOI Creative Commons
Yinyin Bao

Macromolecular Rapid Communications, Journal Year: 2022, Volume and Issue: 43(14)

Published: May 17, 2022

3D printing has revolutionized the way of manufacturing with a huge impact on various fields, in particular biomedicine. Vat photopolymerization-based techniques such as stereolithography (SLA) and digital light processing (DLP) attract considerable attention owing to their superior print resolution, relatively high speed, low cost, flexibility resin material design. As one key element SLA/DLP resin, photoinitiators or photoinitiating systems have experienced significant development recent years, parallel exploration (macro)monomers. The design new cannot only offer faster speed enable low-energy visible fabrication, but also can bring functions printed products even generate methods combination advanced optics. This review evaluates trends application for vat photopolymerization printing, wide range small molecules, polymers, nanoassemblies involved. Personal perspectives current limitations future directions are eventually provided.

Language: Английский

Citations

110
Light-based vat-polymerization bioprinting DOI
Riccardo Levato, Oksana Y. Dudaryeva, Carlos Ezio Garciamendez‐Mijares

et al.

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: June 22, 2023

Language: Английский

Citations

82
Chitosan Poly(vinyl alcohol) Methacrylate Hydrogels for Tissue Engineering Scaffolds DOI Creative Commons

Nghia Le Ba Thai,

Henry T. Beaman,

M. M. Perlman

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

A major challenge in tissue engineering scaffolds is controlling scaffold degradation rates during healing while maintaining mechanical properties to support formation. Hydrogels are three-dimensional matrices that widely applied as based on their unique can mimic the extracellular matrix. In this study, we develop a hybrid natural/synthetic hydrogel platform tune for applications. We modified chitosan and poly(vinyl alcohol) (PVA) with photo-cross-linkable methacrylate functional groups then synthesized library of PVA hydrogels (ChiPVAMA) two different photoinitiators, Irgacure 2959 (I2959) lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). ChiPVAMA showed tunability both polymer content photoinitiator type. This could enable application range 2D scratch wound assay, all samples induced faster closure compared gauze clinical dressing control. NIH/3T3 cells encapsulated high viability (∼92%) over 14 days, demonstrating capacity system supportive cell scaffold. addition, containing higher demonstrated antibacterial capacity. Overall, provide potential tunable, degradable, suitable growth.

Language: Английский

Citations

19
Two-photon polymerization nanolithography technology for fabrication of stimulus-responsive micro/nano-structures for biomedical applications DOI Creative Commons
Zhenjia Huang,

Gary Chi-Pong Tsui,

Yu Deng

et al.

Nanotechnology Reviews, Journal Year: 2020, Volume and Issue: 9(1), P. 1118 - 1136

Published: Jan. 1, 2020

Abstract Micro/nano-fabrication technology via two-photon polymerization (TPP) nanolithography is a powerful and useful manufacturing tool that capable of generating two dimensional (2D) to three (3D) arbitrary micro/nano-structures various materials with high spatial resolution. This has received tremendous interest in cell tissue engineering medical microdevices because its remarkable fabrication capability for sophisticated structures from macro- nano-scale, which are difficult be achieved by traditional methods limited microarchitecture controllability. To fabricate precisely designed 3D biomedical applications TPP nanolithography, the use photoinitiators (PIs) photoresists needs considered comprehensively systematically. In this review, widely used commercially available PIs first discussed, followed elucidating synthesis strategies water-soluble initiators applications. addition conventional photoresists, distinctive properties customized stimulus-responsive discussed. Finally, current limitations challenges material aspects an outlook future prospects based on different biocompatible photosensitive composites discussed comprehensively. all, review provides basic understanding important roles fabricating high-precision wide range

Language: Английский

Citations

92
Recent advances on chalcone-based photoinitiators of polymerization DOI Creative Commons
Malika Ibrahim‐Ouali, Frédéric Dumur

European Polymer Journal, Journal Year: 2021, Volume and Issue: 158, P. 110688 - 110688

Published: Aug. 5, 2021

Language: Английский

Citations

86
Systematic optimization of visible light-induced crosslinking conditions of gelatin methacryloyl (GelMA) DOI Creative Commons
Sina Sharifi,

Hannah Sharifi,

Ali Akbari

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Dec. 2, 2021

Gelatin methacryloyl (GelMA) is one of the most widely used photo-crosslinkable biopolymers in tissue engineering. In presence an appropriate photoinitiator, light activation triggers crosslinking process, which provides shape fidelity and stability at physiological temperature. Although ultraviolet (UV) has been extensively explored for photo-crosslinking, its application linked to numerous biosafety concerns, originated from UV phototoxicity. Eosin Y, combination with TEOA VC, a biosafe photoinitiation system that can be activated via visible instead bypasses those concerns; however, needs fine-tuning optimization. order systematically optimize conditions, we herein independently varied concentrations Y [(EY)], triethanolamine (TEOA), vinyl caprolactam (VC), GelMA precursor, times assessed effect parameters on properties hydrogel. Our data showed except EY, exhibited optimal concentration (~ 0.05 mM), increasing [TEOA], [VA], [GelMA], or time improved mechanical (tensile strength/modulus compressive modulus), adhesion (lap shear strength), swelling, biodegradation However, reagents ([TEOA], [GelMA]) reduced cell viability 3-dimensional (3D) culture. This study enabled us conditions improve hydrogel generate library hydrogels defined essential different biomedical applications.

Language: Английский

Citations

74