Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1152 - 1152
Published: April 5, 2023
The
current
healthcare
system
is
widely
based
on
the
concept
of
“one
size
fit
for
all”,
which
emphasizes
treating
a
disease
by
prescribing
same
drug
to
all
patients
with
equivalent
doses
and
dosing
frequency.
This
medical
treatment
scenario
has
shown
varied
responses
either
no
or
weak
pharmacological
effects
exaggerated
adverse
reactions
preceded
more
patient
complications.
hitches
fits
all”
have
devoted
attention
many
researchers
unlocking
personalized
medicine
(PM).
PM
delivers
customized
therapy
highest
safety
margin
an
individual
patient’s
needs.
potential
revolutionize
pave
way
alter
choices
according
clinical
responses,
providing
physicians
best
outcomes.
3D
printing
techniques
solid-form
fabrication
method
whereby
successive
layers
materials
computer-aided
designs
were
deposited
form
structures.
printed
formulation
achieves
goals
delivering
desired
dose
needs
release
profile
achieve
personal
therapeutic
nutritional
pre-designed
attains
optimum
absorption
distribution,
exhibiting
maximum
efficacy
profiles.
review
aims
focus
role
technique
as
promising
tool
design
in
metabolic
syndrome
(MS).
Sensors,
Journal Year:
2024,
Volume and Issue:
24(9), P. 2668 - 2668
Published: April 23, 2024
Additive
manufacturing
has
revolutionized
across
a
spectrum
of
industries
by
enabling
the
production
complex
geometries
with
unparalleled
customization
and
reduced
waste.
Beginning
as
rapid
prototyping
tool,
additive
matured
into
comprehensive
solution,
embracing
wide
range
materials,
such
polymers,
metals,
ceramics,
composites.
This
paper
delves
workflow
manufacturing,
encompassing
design,
modeling,
slicing,
printing,
post-processing.
Various
technologies
are
explored,
including
material
extrusion,
VAT
polymerization,
jetting,
binder
selective
laser
sintering,
melting,
direct
metal
electron
beam
multi-jet
fusion,
energy
deposition,
carbon
fiber
reinforced,
laminated
object
more,
discussing
their
principles,
advantages,
disadvantages,
compatibilities,
applications,
developing
trends.
Additionally,
future
is
projected,
highlighting
potential
advancements
in
3D
bioprinting,
food
large-scale
4D
AI-based
manufacturing.
survey
aims
to
underscore
transformative
impact
on
global
emphasizing
ongoing
challenges
promising
horizon
innovations
that
could
further
elevate
its
role
revolution.
Progress in Materials Science,
Journal Year:
2024,
Volume and Issue:
144, P. 101282 - 101282
Published: March 12, 2024
This
comprehensive
review
discusses
the
recent
progress
in
synthesis,
properties,
applications,
3D
printing
and
machine
learning
of
graphene
quantum
dots
(GQDs)
polymer
composites.
It
explores
various
synthesis
methods,
highlighting
size
control
surface
functionalization
GQDs.
The
unique
electronic
structure,
tunable
bandgap,
optical
properties
GQDs
are
examined.
Strategies
for
incorporating
into
matrices
their
effects
on
mechanical,
electrical,
thermal,
discussed.
Applications
GQD-based
composites
optoelectronics,
energy
storage,
sensors,
biomedical
devices
also
reviewed.
challenges
future
prospects
explored,
aiming
to
provide
researchers
with
a
understanding
further
advancements
that
should
be
possible
related
fields.
Moreover,
this
article
new
developments
technology
can
benefit
from
promise
composite
materials
loaded
dots,
promising
class
wide
range
potential
applications.
In
addition
discussing
GQDs,
delves
emerging
role
techniques
optimising
GQD-polymer
materials.
Furthermore,
it
how
artificial
intelligence
data-driven
approaches
revolutionising
design
characterisation
these
nanocomposites,
enabling
navigate
vast
parameter
space
efficiently
achieve
desired
properties.
overall
aim
is
build
up
common
platform
connecting
individual
subsections
GQD
nanocomposites
together
generate
readers.
AAPS PharmSciTech,
Journal Year:
2023,
Volume and Issue:
24(8)
Published: Nov. 14, 2023
Abstract
This
review
explores
recent
advancements
and
applications
of
3D
printing
in
healthcare,
with
a
focus
on
personalized
medicine,
tissue
engineering,
medical
device
production.
It
also
assesses
economic,
environmental,
ethical
considerations.
In
our
the
literature,
we
employed
comprehensive
search
strategy,
utilizing
well-known
databases
like
PubMed
Google
Scholar.
Our
chosen
keywords
encompassed
essential
topics,
including
printing,
nanotechnology,
related
areas.
We
first
screened
article
titles
abstracts
then
conducted
detailed
examination
selected
articles
without
imposing
any
date
limitations.
The
for
inclusion,
comprising
research
studies,
clinical
investigations,
expert
opinions,
underwent
meticulous
quality
assessment.
methodology
ensured
incorporation
high-quality
sources,
contributing
to
robust
exploration
role
realm
healthcare.
highlights
printing's
potential
customized
drug
delivery
systems,
patient-specific
implants,
prosthetics,
biofabrication
organs.
These
innovations
have
significantly
improved
patient
outcomes.
Integration
nanotechnology
has
enhanced
precision
biocompatibility.
demonstrates
cost-effectiveness
sustainability
through
optimized
material
usage
recycling.
healthcare
sector
witnessed
remarkable
progress
promoting
patient-centric
approach.
From
implants
radiation
shielding
offers
tailored
solutions.
Its
transformative
applications,
coupled
economic
viability
sustainability,
revolutionize
Addressing
biocompatibility,
standardization,
concerns
is
responsible
adoption.
Graphical
Advances in Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
324, P. 103095 - 103095
Published: Jan. 28, 2024
Direct
ink
writing
(DIW)
stands
as
a
pioneering
additive
manufacturing
technique
that
holds
transformative
potential
in
the
field
of
hydrogel
fabrication.
This
innovative
approach
allows
for
precise
deposition
inks
layer
by
layer,
creating
complex
three-dimensional
structures
with
tailored
shapes,
sizes,
and
functionalities.
By
harnessing
versatility
hydrogels,
DIW
opens
up
possibilities
applications
spanning
from
tissue
engineering
to
soft
robotics
wearable
devices.
comprehensive
review
investigates
applied
hydrogels
its
multifaceted
applications.
The
paper
introduces
diverse
range
printing
techniques
while
providing
thorough
exploration
hydrogel-based
printing.
investigation
aims
explain
progress
made,
challenges
faced,
trajectories
lie
ahead
manufacturing.
fundamental
principles
underlying
are
carefully
examined,
specifically
focusing
on
rheological
attributes
parameters,
prompting
survey
wide
variety
materials.
These
encompass
both
natural
synthetic
variations,
all
which
can
be
effectively
harnessed
this
purpose.
Furthermore,
explores
latest
biomedical
areas,
primary
focus
engineering,
wound
dressing,
drug
delivery
systems.
document
not
only
consolidates
existing
state
within
context
but
also
charts
avenues
further
research
breakthroughs.
Progress in Materials Science,
Journal Year:
2024,
Volume and Issue:
146, P. 101336 - 101336
Published: July 9, 2024
This
review
paper
comprehensively
examines
the
dynamic
landscape
of
3D
printing
and
Machine
Learning
utilizing
biodegradable
polymers
their
composites,
presenting
a
panoramic
synthesis
research
developments,
technological
achievements,
emerging
applications.
By
investigating
multitude
polymer
types,
delineates
suitability
compatibility
with
diverse
methodologies
demonstrates
merit
machine
learning
techniques,
in
future
manufacturing
processes.
Moreover,
this
focuses
on
intricacies
material
preparation,
design
adaptation
as
well
post-processing
techniques
tailored
for
polymers,
elucidating
pivotal
role
achieving
structural
integrity
functional
excellence.
From
biomedical
implants
sustainable
packaging
solutions
to
artistic
creations,
unveils
expansive
spectrum
practical
implementations,
thus
portraying
multifaceted
impact
technology.
Whilst
outlining
prevalent
challenges
such
mechanical
properties
recycling,
concurrently
surveys
ongoing
endeavors
aimed
at
addressing
these
limitations.
In
essence,
encapsulates
transformative
potential
providing
roadmap
advancements
underscoring
its
fostering
manufacturing/consumption
future.
AAPS PharmSciTech,
Journal Year:
2024,
Volume and Issue:
25(2)
Published: Feb. 14, 2024
Abstract
Hot-melt
extrusion
(HME)
is
a
globally
recognized,
robust,
effective
technology
that
enhances
the
bioavailability
of
poorly
soluble
active
pharmaceutical
ingredients
and
offers
an
efficient
continuous
manufacturing
process.
The
twin-screw
extruder
(TSE)
extremely
resourceful
customizable
mixer
used
for
compounding
granulation
by
using
different
combinations
conveying
elements,
kneading
elements
(forward
reverse
configuration),
distributive
mixing
elements.
TSE
thus
efficiently
utilized
dry,
wet,
or
melt
not
only
to
manufacture
dosage
forms
such
as
tablets,
capsules,
granule-filled
sachets,
but
also
designing
novel
formulations
dry
powder
inhalers,
drying
units
granules,
nanoextrusion,
3D
printing,
complexation,
amorphous
solid
dispersions.
Over
past
decades,
combined
academic
industry
collaborations
have
driven
innovations
HME
technology,
which
has
resulted
in
substantial
increase
published
articles
patents.
This
article
summarizes
challenges
models
executing
scale-up.
Additionally,
it
covers
benefits
manufacturing,
process
analytical
(PAT)
considerations,
regulatory
requirements.
In
summary,
this
well-designed
review
builds
upon
our
earlier
publication,
probing
deeper
into
potential
extruders
various
new
applications.
Graphical
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 10, 2024
Three-dimensional
(3D)
printing
technology
has
revolutionized
dentistry,
particularly
in
fabricating
provisional
restorations.
This
systematic
review
and
meta-analysis
aimed
to
thoroughly
evaluate
the
flexural
strength
of
restorations
produced
using
3D
while
considering
impact
different
resin
materials.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(3), P. 032001 - 032001
Published: April 3, 2024
Abstract
With
the
advent
of
personalized
medicine,
drug
delivery
system
will
be
changed
significantly.
The
development
medicine
needs
support
many
technologies,
among
which
three-dimensional
printing
(3DP)
technology
is
a
novel
formulation-preparing
process
that
creates
3D
objects
by
depositing
materials
layer-by-layer
based
on
computer-aided
design
method.
Compared
with
traditional
pharmaceutical
processes,
3DP
produces
complex
combinations,
dosage,
and
flexible
shape
structure
dosage
forms
(DFs)
demand.
In
future,
drugs
may
supplement
even
replace
their
counterpart.
We
systematically
introduce
applications
technologies
in
industry
summarize
virtues
shortcomings
each
technique.
release
behaviors
control
mechanisms
DFs
desired
structures
are
also
analyzed.
Finally,
benefits,
challenges,
prospects
to
discussed.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3836 - 3836
Published: March 29, 2024
Presently,
millions
worldwide
suffer
from
degenerative
and
inflammatory
bone
joint
issues,
comprising
roughly
half
of
chronic
ailments
in
those
over
50,
leading
to
prolonged
discomfort
physical
limitations.
These
conditions
become
more
prevalent
with
age
lifestyle
factors,
escalating
due
the
growing
elderly
populace.
Addressing
these
challenges
often
entails
surgical
interventions
utilizing
implants
or
grafts,
though
treatments
may
entail
complications
such
as
pain
tissue
death
at
donor
sites
for
along
immune
rejection.
To
surmount
challenges,
engineering
has
emerged
a
promising
avenue
injury
repair
reconstruction.
It
involves
use
different
biomaterials
development
three-dimensional
porous
matrices
scaffolds,
alongside
osteoprogenitor
cells
growth
factors
stimulate
natural
regeneration.
This
review
compiles
methodologies
that
can
be
used
develop
are
important
replacement
Biomaterials
orthopedic
implants,
several
scaffold
types
production
methods,
well
techniques
assess
biomaterials’
suitability
human
use—both
laboratory
settings
within
living
organisms—are
discussed.
Even
researchers
have
had
some
success,
there
is
still
room
improvements
their
processing
techniques,
especially
ones
make
scaffolds
mechanically
stronger
without
weakening
biological
characteristics.
Bone
therefore
area
rise
bone-related
injuries.