3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome DOI Creative Commons
Abdulsalam A. Alqahtani, Mohammed Muqtader Ahmed, Abdul Aleem Mohammed

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1152 - 1152

Published: April 5, 2023

The current healthcare system is widely based on the concept of “one size fit for all”, which emphasizes treating a disease by prescribing same drug to all patients with equivalent doses and dosing frequency. This medical treatment scenario has shown varied responses either no or weak pharmacological effects exaggerated adverse reactions preceded more patient complications. hitches fits all” have devoted attention many researchers unlocking personalized medicine (PM). PM delivers customized therapy highest safety margin an individual patient’s needs. potential revolutionize pave way alter choices according clinical responses, providing physicians best outcomes. 3D printing techniques solid-form fabrication method whereby successive layers materials computer-aided designs were deposited form structures. printed formulation achieves goals delivering desired dose needs release profile achieve personal therapeutic nutritional pre-designed attains optimum absorption distribution, exhibiting maximum efficacy profiles. review aims focus role technique as promising tool design in metabolic syndrome (MS).

Language: Английский

Revolutionizing manufacturing: A comprehensive overview of additive manufacturing processes, materials, developments, and challenges DOI
Kumar Kanishka, Bappa Acherjee

Journal of Manufacturing Processes, Journal Year: 2023, Volume and Issue: 107, P. 574 - 619

Published: Nov. 8, 2023

Language: Английский

Citations

125
Additive Manufacturing: A Comprehensive Review DOI Creative Commons
Longfei Zhou,

Jenna Miller,

Jeremiah Vezza

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(9), P. 2668 - 2668

Published: April 23, 2024

Additive manufacturing has revolutionized across a spectrum of industries by enabling the production complex geometries with unparalleled customization and reduced waste. Beginning as rapid prototyping tool, additive matured into comprehensive solution, embracing wide range materials, such polymers, metals, ceramics, composites. This paper delves workflow manufacturing, encompassing design, modeling, slicing, printing, post-processing. Various technologies are explored, including material extrusion, VAT polymerization, jetting, binder selective laser sintering, melting, direct metal electron beam multi-jet fusion, energy deposition, carbon fiber reinforced, laminated object more, discussing their principles, advantages, disadvantages, compatibilities, applications, developing trends. Additionally, future is projected, highlighting potential advancements in 3D bioprinting, food large-scale 4D AI-based manufacturing. survey aims to underscore transformative impact on global emphasizing ongoing challenges promising horizon innovations that could further elevate its role revolution.

Language: Английский

Citations

86
Synthesis, properties, applications, 3D printing and machine learning of graphene quantum dots in polymer nanocomposites DOI Creative Commons

Vimukthi Dananjaya,

Sathish Marimuthu, Chunhui Yang

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101282 - 101282

Published: March 12, 2024

This comprehensive review discusses the recent progress in synthesis, properties, applications, 3D printing and machine learning of graphene quantum dots (GQDs) polymer composites. It explores various synthesis methods, highlighting size control surface functionalization GQDs. The unique electronic structure, tunable bandgap, optical properties GQDs are examined. Strategies for incorporating into matrices their effects on mechanical, electrical, thermal, discussed. Applications GQD-based composites optoelectronics, energy storage, sensors, biomedical devices also reviewed. challenges future prospects explored, aiming to provide researchers with a understanding further advancements that should be possible related fields. Moreover, this article new developments technology can benefit from promise composite materials loaded dots, promising class wide range potential applications. In addition discussing GQDs, delves emerging role techniques optimising GQD-polymer materials. Furthermore, it how artificial intelligence data-driven approaches revolutionising design characterisation these nanocomposites, enabling navigate vast parameter space efficiently achieve desired properties. overall aim is build up common platform connecting individual subsections GQD nanocomposites together generate readers.

Language: Английский

Citations

69
Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic DOI Creative Commons
Lorca Alzoubi, Alaa A. A. Aljabali, Murtaza M. Tambuwala

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)

Published: Nov. 14, 2023

Abstract This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, medical device production. It also assesses economic, environmental, ethical considerations. In our the literature, we employed comprehensive search strategy, utilizing well-known databases like PubMed Google Scholar. Our chosen keywords encompassed essential topics, including printing, nanotechnology, related areas. We first screened article titles abstracts then conducted detailed examination selected articles without imposing any date limitations. The for inclusion, comprising research studies, clinical investigations, expert opinions, underwent meticulous quality assessment. methodology ensured incorporation high-quality sources, contributing to robust exploration role realm healthcare. highlights printing's potential customized drug delivery systems, patient-specific implants, prosthetics, biofabrication organs. These innovations have significantly improved patient outcomes. Integration nanotechnology has enhanced precision biocompatibility. demonstrates cost-effectiveness sustainability through optimized material usage recycling. healthcare sector witnessed remarkable progress promoting patient-centric approach. From implants radiation shielding offers tailored solutions. Its transformative applications, coupled economic viability sustainability, revolutionize Addressing biocompatibility, standardization, concerns is responsible adoption. Graphical

Language: Английский

Citations

56
Innovations in hydrogel-based manufacturing: A comprehensive review of direct ink writing technique for biomedical applications DOI Creative Commons
Hossein Baniasadi, Roozbeh Abidnejad, Mahyar Fazeli

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 324, P. 103095 - 103095

Published: Jan. 28, 2024

Direct ink writing (DIW) stands as a pioneering additive manufacturing technique that holds transformative potential in the field of hydrogel fabrication. This innovative approach allows for precise deposition inks layer by layer, creating complex three-dimensional structures with tailored shapes, sizes, and functionalities. By harnessing versatility hydrogels, DIW opens up possibilities applications spanning from tissue engineering to soft robotics wearable devices. comprehensive review investigates applied hydrogels its multifaceted applications. The paper introduces diverse range printing techniques while providing thorough exploration hydrogel-based printing. investigation aims explain progress made, challenges faced, trajectories lie ahead manufacturing. fundamental principles underlying are carefully examined, specifically focusing on rheological attributes parameters, prompting survey wide variety materials. These encompass both natural synthetic variations, all which can be effectively harnessed this purpose. Furthermore, explores latest biomedical areas, primary focus engineering, wound dressing, drug delivery systems. document not only consolidates existing state within context but also charts avenues further research breakthroughs.

Language: Английский

Citations

56
3D printing of biodegradable polymers and their composites – Current state-of-the-art, properties, applications, and machine learning for potential future applications DOI Creative Commons
S. A. V. Dananjaya, Venkata S. Chevali, John P. Dear

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101336 - 101336

Published: July 9, 2024

This review paper comprehensively examines the dynamic landscape of 3D printing and Machine Learning utilizing biodegradable polymers their composites, presenting a panoramic synthesis research developments, technological achievements, emerging applications. By investigating multitude polymer types, delineates suitability compatibility with diverse methodologies demonstrates merit machine learning techniques, in future manufacturing processes. Moreover, this focuses on intricacies material preparation, design adaptation as well post-processing techniques tailored for polymers, elucidating pivotal role achieving structural integrity functional excellence. From biomedical implants sustainable packaging solutions to artistic creations, unveils expansive spectrum practical implementations, thus portraying multifaceted impact technology. Whilst outlining prevalent challenges such mechanical properties recycling, concurrently surveys ongoing endeavors aimed at addressing these limitations. In essence, encapsulates transformative potential providing roadmap advancements underscoring its fostering manufacturing/consumption future.

Language: Английский

Citations

35
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now? DOI Creative Commons

Hemlata Patil,

Sateesh Kumar Vemula, Sagar Narala

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(2)

Published: Feb. 14, 2024

Abstract Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) extremely resourceful customizable mixer used for compounding granulation by using different combinations conveying elements, kneading elements (forward reverse configuration), distributive mixing elements. TSE thus efficiently utilized dry, wet, or melt not only to manufacture dosage forms such as tablets, capsules, granule-filled sachets, but also designing novel formulations dry powder inhalers, drying units granules, nanoextrusion, 3D printing, complexation, amorphous solid dispersions. Over past decades, combined academic industry collaborations have driven innovations HME technology, which has resulted in substantial increase published articles patents. This article summarizes challenges models executing scale-up. Additionally, it covers benefits manufacturing, process analytical (PAT) considerations, regulatory requirements. In summary, this well-designed review builds upon our earlier publication, probing deeper into potential extruders various new applications. Graphical

Language: Английский

Citations

33
The flexural strength of 3D-printed provisional restorations fabricated with different resins: a systematic review and meta-analysis DOI Creative Commons

Ravinder Saini,

Vishwanath Gurumurthy,

Syed Altafuddin Quadri

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 10, 2024

Three-dimensional (3D) printing technology has revolutionized dentistry, particularly in fabricating provisional restorations. This systematic review and meta-analysis aimed to thoroughly evaluate the flexural strength of restorations produced using 3D while considering impact different resin materials.

Language: Английский

Citations

27
3D printing processes in precise drug delivery for personalized medicine DOI Creative Commons
Haisheng Peng, Bo Han, Tianjian Tong

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032001 - 032001

Published: April 3, 2024

Abstract With the advent of personalized medicine, drug delivery system will be changed significantly. The development medicine needs support many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing materials layer-by-layer based on computer-aided design method. Compared with traditional pharmaceutical processes, 3DP produces complex combinations, dosage, and flexible shape structure dosage forms (DFs) demand. In future, drugs may supplement even replace their counterpart. We systematically introduce applications technologies in industry summarize virtues shortcomings each technique. release behaviors control mechanisms DFs desired structures are also analyzed. Finally, benefits, challenges, prospects to discussed.

Language: Английский

Citations

26
An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells DOI Open Access
María Pía Ferraz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

Citations

20