Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 332, P. 312 - 336

Published: Feb. 27, 2021

Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related drug administration, from the low water-solubility poor permeability across biological barriers. With respect other nanocarriers, polymeric micelles generally display smaller size, easier preparation and sterilization processes, good solubilization properties, unfortunately associated with a lower stability fluids more complicated characterization. Particularly challenging is study their interaction environment, essential predict real vivo behavior after administration. In this review, general presentation on features different characterization techniques are discussed, ones used for determination basic characteristics (critical micellar concentration, surface charge, morphology) complex approaches figure out kinetic stability, release presence substrates (fluids, cells tissues). The presented (such as dynamic light scattering, AFM, cryo-TEM, X-ray FRET, symmetrical flow field-flow fractionation (AF4) density ultracentrifugation), each one own advantages limitations, can be combined achieve deeper comprehension behavior. set-up validation adequate methods description starting point development clinical success.

Language: Английский

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Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

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Bactericidal activity of silver nanoparticles: A mechanistic review

Materials Science for Energy Technologies, Journal Year: 2020, Volume and Issue: 3, P. 756 - 769

Published: Jan. 1, 2020

Metallic nanoparticles such as silver (AgNPs) have gained lots of attention due to the continuous upsurge in microbial infections and diseases, also inefficient treatment. Also, rapid intensification antibiotic resistance this period has revived consideration researchers scientists explore therapeutic abilities its nanoparticulate systems potential antimicrobial agents. Indeed, numerous studies suggested that AgNPs exhibited significant actions, specifically against bacterial infections. Ample been performed evaluate estimate antibacterial potentials associated products, it was noticed they these Ag-particles triggers oxidative stress, protein dysfunction, membrane DNA damage, leading cell damage. Although activities, but adverse effects over human health a major concern. Further, review we summarized significance AgNPs, various approaches for preparation mechanism probable toxicity environment. Furthermore, focused consider mechanisms behind bactericidal actions nanoparticles-based systems, followed by comprehensive ideas related their toxic potentials. This would open new robust possibilities develop nanoparticle-based with desired properties effective treatment humans.

Language: Английский

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Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 971 - 1012

Published: Feb. 28, 2022

Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup resistances. However, significant technological advancements have been made in terms superior modes delivery over the last few decades. Technical capability analyzing molecular mechanisms tumor biology, nanotechnology─particularly development biocompatible nanoparticles, surface modification techniques, microelectronics, material sciences─has increased. As a result, number nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency developed. This particular maneuver enables introduction substance body by controlling rate, time, place is defined system (NDDS). Because their versatility ability incorporate features water solubility, stability, biocompatibility, degradability, reverse resistance, they attracted interest scientific community, general, nanotechnologists well biomedical scientists. To keep pace rapid advancement nanotechnology, technical aspects recent NDDSs prospects need be reported coherently. address these ongoing issues, this review article provides an overview different lipids, polymers, inorganic nanoparticles. In addition, also reports challenges current points out prospective research directions nanocarriers. From our focused review, we conclude still now most advanced potent field application lipid-based, while significantly potential fields include polymer-based NDDSs. despite promises, remain practical implementations dosage caution should exercised regarding biocompatibility materials. Considering objectively, on will particularly small-to-large scale industrial researchers academicians expertise delivery, research, nanotechnology.

Language: Английский

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Fundamentals and developments in fluorescence-guided cancer surgery

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 19(1), P. 9 - 22

Published: Sept. 7, 2021

Language: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 883 - 883

Published: April 18, 2022

There has been an increasing demand for the development of nanocarriers targeting multiple diseases with a broad range properties. Due to their tiny size, giant surface area and feasible targetability, have optimized efficacy, decreased side effects improved stability over conventional drug dosage forms. are diverse types that synthesized delivery, including dendrimers, liposomes, solid lipid nanoparticles, polymersomes, polymer–drug conjugates, polymeric peptide micelles, nanoemulsions, nanospheres, nanocapsules, nanoshells, carbon nanotubes gold etc. Several characterization techniques proposed used past few decades control predict behavior both in vitro vivo. In this review, we describe some fundamental vitro, ex vivo, situ vivo methods most nanocarriers, emphasizing advantages limitations, as well safety, regulatory manufacturing aspects hinder transfer from laboratory clinic. Moreover, integration artificial intelligence nanotechnology, problems optimization also discussed, along future perspectives.

Language: Английский

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Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 3, 2022

Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.

Language: Английский

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Nanotechnology in ovarian cancer: Diagnosis and treatment

Life Sciences, Journal Year: 2020, Volume and Issue: 266, P. 118914 - 118914

Published: Dec. 16, 2020

Language: Английский

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Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

Molecules, Journal Year: 2021, Volume and Issue: 26(6), P. 1770 - 1770

Published: March 22, 2021

Gums are carbohydrate biomolecules that have the potential to bind water and form gels. regularly linked with proteins minerals in their construction. several forms, such as mucilage gums, seed exudate etc. Plant gums one of most important because bioavailability. Plant-derived been used by humans since ancient times for numerous applications. The main features make them appropriate use different applications high stabilization, viscosity, adhesive property, emulsification action, surface-active activity. In many pharmaceutical formulations, plant-based mucilages key ingredients due bioavailability, widespread accessibility, non-toxicity, reasonable prices. These compete polymeric materials pharmaceuticals today’s time created a significant achievement from being an excipient innovative drug carriers. particular, scientists pharmacy industries around world drawn uncover secret through deeper understanding physicochemical characteristics development safety profile information. This unique class products, useful advanced delivery applications, gene therapy, biosynthesis, has developed modification mucilages. this review, both fundamental novel medicinal aspects mucilages, along capacity pharmacology nanomedicine, were demonstrated.

Language: Английский

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