Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093
Published: July 25, 2024
Language: Английский
Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1473 - 1473
Published: Feb. 3, 2023
The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hydrogels have frequently been used for hemostasis due their unique biocompatibility, tunable mechanical properties, injectability, and ease handling. Moreover, chitosan (CS) absorbs red blood cells activates platelets promote hemostasis. Benefiting from these desired the application CS attracting ever-increasing research attention. This paper reviews recent progress CS-based advantageous characteristics compared traditional materials. effects mechanism, deacetylation degree, relative molecular mass, chemical modification on performance are summarized. Meanwhile, some typical applications introduced provide references preparation efficient hydrogels. Finally, future perspectives presented.
Language: Английский
Citations
95
Polymers, Journal Year: 2022, Volume and Issue: 14(16), P. 3266 - 3266
Published: Aug. 11, 2022
Bleeding control plays a very important role in worldwide healthcare, which also promotes research and development of wound dressings. The healing process involves four stages hemostasis, inflammation, proliferation remodeling, is complex process, dressings play huge it. Electrospinning technology simple to operate. Electrospun nanofibers have high specific surface area, porosity, oxygen permeability, excellent mechanical properties, show great utilization value the manufacture As one most popular reactive functional synthetic polymers, polyacrylonitrile (PAN) frequently explored create for wide variety applications. In recent years, researchers invested application PAN Research on spun reviewed, future directions prospects electrospun are proposed.
Language: Английский
Citations
84
Journal of Polymer Science, Journal Year: 2023, Volume and Issue: 61(14), P. 1389 - 1414
Published: March 27, 2023
Abstract Wound healing is a complicated system that necessitates an appropriate environment to aid healing. dressing among the most important external variables in wound repair. Technology advancements have led creation of variety dressings treat various types by focusing on four stages Simplicity application, sterility, antibacterial, non‐adherent, gaseous exchange, non‐toxicity, and other qualities are necessary for dressings. In order fully regenerate restore structure functionality skin, ideal should address demands wound. So, kind used based type injury. This review focuses different natural polymers such as κ‐carrageenan, chitosan, cellulose, gelatin, collagen, alginate, hyaluronic acid, silk fibroin development materials hydrogels, nanofibers, sponges, films, scaffolds owing their features, example, biocompatibility, biodegradability, similarity human extracellular matrix (ECM) which aids process. The commercially available products these also discussed review. However, majority polymer‐based still exhibit number problems like adherence, opaque, fast degradability, lack multifunctionality, thus need be addressed. A naturally inspired smart hour individual monitoring multiple pH, temperature, electrical potentials eases incorporated drug biological molecules per progress with delivery systems.
Language: Английский
Citations
78
Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 140(22)
Published: April 12, 2023
Abstract Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that widely used in wound healing. This is due to their biocompatibility chemical structural similarity extracellular matrix (ECM). Wound healing a complex process requires multidisciplinary approach appropriate treatment product enable full recovery. Chronic nonhealing wounds significantly caused reduction. Currently, diabetic considered unmet clinical need new effective will benefit patients economy. research was aimed critically review both literature as well industrial products carbohydrates proteins dressing for wound. The outcome chitosan (CS), carbohydrate, has most application it readily available affordable, shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr not yet found use when compared CS.
Language: Английский
Citations
49
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130296 - 130296
Published: Feb. 19, 2024
Language: Английский
Citations
25
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115217 - 115217
Published: Feb. 27, 2024
Language: Английский
Citations
24
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 1, 2024
Disturbing or disrupting the regular healing process of a skin wound may result in its progression to chronic state. Chronic wounds often lead increased infection because their long time, malnutrition, and insufficient oxygen flow, subsequently affecting progression. Gelatin—the main structure natural collagen—is widely used biomedical fields low cost, wide availability, biocompatibility, degradability. However, gelatin exhibit diverse tailored physical properties poor antibacterial activity. Research on gelatin-based biomaterials has identified challenges improving gelatin’s mechanical properties. In wounds, can promote hemostasis, enhance peri-wound anti-inflammatory properties, vascular epithelial cell regeneration. this article, we first introduce healing. Second, present role as an additive Finally, future implications biomaterials.
Language: Английский
Citations
20
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: Jan. 2, 2025
Abstract The field of chronic wound care has been rapidly evolving. With a market size for wounds in billions USD, this is not an insignificant area to encourage more sustainable practices and processes. sourcing starting materials dressings from renewable resources the first crucial step ensuring that environmental impact minimized. Next important choice select methodologies accordance with principles green chemistry. This involves utilizing solvents as reaction media chemical processes preparing dressing materials. In many cases, like production hydrogels, crosslinking reagents are often employed. These can be, general, easily replaced by enzymes peroxidases, tyrosinases sortases. Process intensification strategies have emerged powerful approach ensure economy sustainability at large scale. Use microwave radiations ultrasonication instead heat accelerate rates helps cases inject wounds. review attempts highlight ongoing efforts future possibilities development cost-effective methods. Graphical
Language: Английский
Citations
4
Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435
Published: Feb. 7, 2025
Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141570 - 141570
Published: Feb. 27, 2025
Language: Английский
Citations
4