Pullulan/Poly(vinyl alcohol) Hydrogels Loaded with Calendula officinalis Extract: Design and In Vitro Evaluation for Wound Healing Applications DOI Creative Commons
Irina Mihaela Pelin, Mihaela Silion, Irina Popescu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1674 - 1674

Published: June 7, 2023

The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due high capacity absorb exudates and enhanced performance in loading releasing extracts. In this work, pullulan/poly (vinyl alcohol) (P/PVA) hydrogels were first prepared using an eco-friendly method based on both a covalent physical cross-linking approach. Then, the loaded with hydroalcoholic extract Calendula officinalis simple post-loading immersion method. Different capacities investigated terms physico-chemical properties, chemical composition, mechanical water absorption. exhibited hydrogen bonding interactions between polymer extract. retention well properties decreased increase amount hydrogel. However, higher amounts hydrogel improved bioadhesiveness. release from was controlled Fickian diffusion mechanism. Extract-loaded expressed antioxidant activity, reaching 70% DPPH radical scavenging after 15 min buffer solution at pH 5.5. Additionally, showed antibacterial activity against Gram-positive Gram-negative bacteria non-cytotoxic HDFa cells.

Language: Английский

Biomedical materials for wound dressing: recent advances and applications DOI Creative Commons
Hien Minh Nguyen,

Tam Thi Ngoc Le,

An Thanh Nguyen

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(8), P. 5509 - 5528

Published: Jan. 1, 2023

Wound healing is vital to maintain the physiological functions of skin.

Language: Английский

Citations

217

Bacterial Cellulose and Its Applications DOI Open Access
Soon Mo Choi,

Kummara Madhusudana Rao,

Sun Mi Zo

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(6), P. 1080 - 1080

Published: March 8, 2022

The sharp increase in the use of cellulose seems to be increasing demand wood; much more research related sustainable or alternative materials is necessary as a lot arable land and natural resources unsustainable. In accordance, attention has focused on bacterial new functional material. It possesses three-dimensional, gelatinous structure consisting with mechanical thermal properties. Moreover, while plant-originated composed cellulose, hemi-cellulose, lignin, attributable composition pure nanofiber mesh spun not elimination other components. due its hydrophilic nature caused by binding water, consequently being hydrogel well biocompatibility, it only used medical fields including artificial skin, cartilage, vessel, wound dressing, but also delivery; some products have even been commercialized. addition, widely various technologies food, paper, textile, electronic electrical applications, considered highly versatile green material tremendous potential. However, many efforts conducted for evolution novel sophisticated environmental affinity, which accompany empowerment enhancement specific this review article, we summarized industry status regarding BC contemplated potential BC.

Language: Английский

Citations

150

Progress in Hydrogels for Skin Wound Repair DOI

Liangfa Qi,

Chenlu Zhang, Bo Wang

et al.

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(7)

Published: April 7, 2022

Abstract As the first defensive line between human body and outside world, skin is vulnerable to damage from external environment. Skin wounds can be divided into acute (mechanical injuries, chemical surgical wounds, etc.) chronic (burns, infections, diabetes, etc.). In order manage wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, hydrogels. Recently, hydrogels received much attention because their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, facile bioactive substance delivery capability. They show great potential application in repair. This paper introduces anatomy function skin, process healing conventional dressings, then composition construction methods Next, this necessary properties repair latest research progress hydrogel for Finally, future development goals materials field are proposed.

Language: Английский

Citations

146

Recent advances in regenerative biomaterials DOI
Dinglingge Cao, Jiandong Ding

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring

Language: Английский

Citations

143

A Brief Review on the Development of Alginate Extraction Process and Its Sustainability DOI Open Access

Sijin Saji,

Andrew Hebden, Parikshit Goswami

et al.

Sustainability, Journal Year: 2022, Volume and Issue: 14(9), P. 5181 - 5181

Published: April 25, 2022

Alginate is an attractive marine resource-based biopolymer, which has been widely used in pharmaceutical, food and textile industries. This paper reviewed the latest development of conventional alternative processes for alginate extraction from brown seaweed. To improve yield product quality, various studies have carried out to optimize operation condition. Based on literature survey, most commonly protocol soaking milled seaweed 2% (w/v) formaldehyde, overnight, solid loading ratio 1:10–20 (dry weight biomass solution), then collecting acid pre-treatment with HCl 0.2–2% (w/v), 40–60 °C, 1:10–30 2–4 h. Next, residue extracted using Na2CO3 at 2–4% 2–3 h, ratio. Then liquid portion precipitated by ethanol (95%+) a 1:1 (v/v). Finally, output dried oven 50–60 °C. Novel methods ultrasound, microwave, enzymes extrusion improved properties, but financial benefits not fully justified yet. sustainable production alginate, it required promote cultivation, reduce water footprint, decrease organic solvent usage co-produce other value-added products.

Language: Английский

Citations

118

Carrageenan-Based Compounds as Wound Healing Materials DOI Open Access
Bogdan Neamțu, Andreea Barbu, Mihai Octavian Negrea

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9117 - 9117

Published: Aug. 14, 2022

The following review is focused on carrageenan, a heteroglycan-based substance that very significant wound healing biomaterial. Every biomaterial has advantages and weaknesses of its own, but these drawbacks are typically outweighed by combining the material in various ways with other substances. Carrageenans' key benefits include their water solubility, which enables them to keep periwound damp absorb exudate. They have low cytotoxicity, antimicrobial antioxidant qualities, do not stick bed, hence cause pain when removed from wounded region. When combined materials, they can aid hemostasis. This emphasizes using carrageenan for healing, including use several mixes improve properties.

Language: Английский

Citations

84

Biomaterials technology and policies in the building sector: a review DOI Creative Commons
Lin Chen, Yubing Zhang, Zhonghao Chen

et al.

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(2), P. 715 - 750

Published: Jan. 29, 2024

Abstract Traditional building materials have some drawbacks in the construction industry, particularly terms of greenhouse gas emissions and energy consumption. Biomaterials derived from renewable sources are a promising alternative, significantly reducing effect enhancing efficiency. However, traditional still dominate sector, there is lack understanding among policymakers developers regarding biomaterials. Here, we review biomaterials their policies life cycle assessment through case studies. Bio-based potential to reduce over 320,000 tons carbon dioxide by 2050. They also exhibit advantages like decreasing water absorption 40%, consumption 8.7%, acoustic 6.7%, improving mechanical properties. We summarize recent advancements mycelial materials, bioconcrete, natural fibers, fiber-reinforced composites. explore contributions nanotechnology microalgae technology biomaterials' thermal insulation eco-friendliness.

Language: Английский

Citations

80

Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management DOI

Wen Fang,

Ling Yang, Yi‐Hao Chen

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 50 - 66

Published: Jan. 12, 2023

Language: Английский

Citations

68

Exopolysaccharides Producing Bacteria: A Review DOI Creative Commons
А. И. Нетрусов, Elena V. Liyaskina,

Irina V. Kurgaeva

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1541 - 1541

Published: June 9, 2023

Bacterial exopolysaccharides (EPS) are essential natural biopolymers used in different areas including biomedicine, food, cosmetic, petroleum, and pharmaceuticals also environmental remediation. The interest them is primarily due to their unique structure properties such as biocompatibility, biodegradability, higher purity, hydrophilic nature, anti-inflammatory, antioxidant, anti-cancer, antibacterial, immune-modulating prebiotic activities. present review summarizes the current research progress on bacterial EPSs properties, biological functions, promising applications various fields of science, industry, medicine, technology, well characteristics isolation sources EPSs-producing strains. This provides an overview latest advances study important industrial xanthan, cellulose, levan. Finally, limitations future directions discussed.

Language: Английский

Citations

61

Intelligent biobased hydrogels for diabetic wound healing: A review DOI
Hanzhang Wang, Liming Zhang

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

Citations

56