Published: Jan. 1, 2025
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 314, P. 120965 - 120965
Published: April 28, 2023
Over the last years, polysaccharides have been linked to antioxidant effects using both in vitro chemical and biological models. The reported structures, claimed act as antioxidants, comprise chitosan, pectic polysaccharides, glucans, mannoproteins, alginates, fucoidans, many others of all type sources. structural features action include polysaccharide charge, molecular weight, occurrence non-carbohydrate substituents. establishment structure/function relationships can be, however, biased by secondary phenomena that tailor behavior systems. In this sense, review confronts some basic concepts chemistry with current claim carbohydrates antioxidants. It critically discusses how fine structure properties define Polysaccharides is highly dependent on their solubility, sugar ring structure, positive or negatively charged groups, protein moieties covalently phenolic compounds. However, compounds contaminants leads misleading results methodologies often used for screening characterization purposes, well vivo Despite falling concept role must be defined according matrices where they are involved.
Language: Английский
Citations
242
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1364 - 1364
Published: April 28, 2023
Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, microbial-based resources processes can be chemically modified. The biocompatibility biodegradability of polysaccharides enable their increased use in nanoscale synthesis engineering for drug encapsulation release. This review focuses on sustained release studies the fields nanotechnology biomedical sciences. Particular emphasis is placed kinetics relevant mathematical models. An effective model used to envision behavior specific polysaccharide matrices reduce impending experimental trial error, saving time resources. A robust also assist translating vitro vivo experiments. main aim this demonstrate that any study establishes should accompanied by a detailed analysis modeling since not only involves diffusion degradation but surface erosion, complicated swelling dynamics, crosslinking, drug-polymer interactions. As such, first part, we discuss classification role various applications later elaborate pharmaceutical ionic gelling, stabilization, cross-linking, grafting, drugs. We document several models applied hydrogels, nanofibers, nanoparticles conclude that, at times, more than one accurately describe profiles, indicating existence mechanisms running parallel. Finally, future opportunities advanced nanoengineered theranostic aptitudes clinical applications.
Language: Английский
Citations
73
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 503 - 503
Published: Feb. 2, 2023
Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to group of biodegradable, bioavailable, and non-toxic materials natural origin; thus, it promising matrix for creating delivery systems different active agents. Recently, much attention has been paid nanodelivery as carriers enable better bioavailability, thus higher efficiency the loaded drug. The present review focused on progress in chitosan-based nanoparticles targeted antitumor drugs. paper discusses literature reports from last three years which chitosan were applied substances used therapy potential new drugs with anticancer properties. Special was treatments increase therapeutic effectiveness minimize side effects specific substance.
Language: Английский
Citations
44
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 337, P. 122145 - 122145
Published: April 9, 2024
Language: Английский
Citations
39
Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 11, 2025
Chronic diseases such as cancer and diabetes demand advanced drug delivery methods that can accommodate precise, sustained, targeted release of active compounds. Existing carriers conventional capsules are limited by issues like poor bioavailability, mechanical fragility, unpredictable patterns. With the global market expected to surpass USD 1.8 trillion 2028, it is crucial address these challenges. Additionally, there a growing need develop biocompatible systems mitigate concerns about toxicity, environmental impact, patient compliance. Here, we review latest advancements in composite capsules, focusing on key aspects controlled release, properties, biocompatibility, antimicrobial potential. Composite materials offer customised mechanisms combining synthetic natural polymers. This has led improvements stability, encapsulation efficiency, bioavailability. Some noteworthy this field include development magnetic-responsive for therapies, alginate-based dual-release systems, solid lipid nanoparticles (SLNs) gene delivery. For example, lycopene whey protein composites achieved an impressive efficiency 94%, showcasing enhanced performance. have been developments pH-sensitive designed treatment, which drugs selectively tumour environments. Furthermore, multifunctional magnetic created facilitate MRI imaging remote-controlled release. Moreover, proven effective improving therapeutic outcomes treatments ensuring specifically within acidic microenvironment. Other notable achievements integration antioxidant nanoparticles, cerium oxide (CeO₂), into showing potential mitigating oxidative stress providing neuroprotection inflammatory neurodegenerative conditions. Despite innovations, persistent challenges related scalability, regulatory clearance, enduring biocompatibility necessitate further investigation. These combined possess significant potential, presenting more intelligent, adaptable positioned transform personalised medicine future healthcare solutions.
Language: Английский
Citations
2
Polymers, Journal Year: 2023, Volume and Issue: 15(9), P. 2149 - 2149
Published: April 30, 2023
In recent years, polymeric materials have been used in a wide range of applications variety fields. particular, the field bioengineering, use natural biomaterials offers possible new avenue for development products with better biocompatibility, biodegradability, and non-toxicity. This paper reviews structural physicochemical properties alginate hyaluronic acid, as well modified cross-linked derivatives tissue engineering drug delivery. summarizes application acid bone engineering, wound dressings, carriers. We provide some ideas on how to replace or combine alginate-based composites hyaluronic-acid-based delivery achieve eco-economic value.
Language: Английский
Citations
32
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2227 - 2227
Published: Aug. 29, 2023
Therapeutic polysaccharide-based coatings have recently emerged as versatile strategies to transform a conventional medical implant into drug delivery system. However, the translation of these clinic systems still requires deeper understanding their degradation/release profiles. This claim is supported by little or no data. In this review paper, comprehensive description benefits and challenges generated provided. Moreover, latest advances made towards application most important representative based on polysaccharide types for are debated. Furthermore, suggestions/recommendations future research speed up transition from laboratory testing clinical applications given.
Language: Английский
Citations
32
Sustainable Chemistry and Pharmacy, Journal Year: 2023, Volume and Issue: 33, P. 101086 - 101086
Published: April 13, 2023
Language: Английский
Citations
28
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Aug. 2, 2024
Increased mass manufacturing and the pervasive use of plastics in many facets daily life have had detrimental effects on environment. As a result, these worries heighten possibility climate change due to carbon dioxide emissions from burning conventional, non-biodegradable polymers. Accordingly, biodegradable gelatin chitosan polymers are being created as sustainable substitute for polymeric materials various applications. Chitosan is only naturally occurring cationic alkaline polysaccharide, well-known edible polymer derived chitin. The biological activities chitosan, such its antioxidant, anticancer, antimicrobial qualities, recently piqued interest researchers. Similarly, hydrolytic breakdown collagen protein offers medicinal advantages owing unique amino acid composition. In this review, we present an overview recent studies focusing applying fields. These include using food packaging, antioxidants properties, properties encapsulating biologically active substances, tissue engineering, microencapsulation technology, water treatment, drug delivery. This review emphasizes significance investigating options plastics. It showcases diverse uses tackling environmental issues driving progress across different industries.
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130949 - 130949
Published: March 18, 2024
Language: Английский
Citations
11