Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 523 - 523

Published: June 27, 2023

Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.

Language: Английский

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Polymer-based low dielectric constant and loss materials for high-speed communication network: Dielectric constants and challenges

European Polymer Journal, Journal Year: 2023, Volume and Issue: 200, P. 112543 - 112543

Published: Oct. 28, 2023

Language: Английский

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Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

RSC Advances, Journal Year: 2023, Volume and Issue: 13(50), P. 35251 - 35291

Published: Jan. 1, 2023

Nanocomposite hydrogel biomaterials represent an exciting frontier in biomedicine, offering solutions to longstanding challenges.

Language: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

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Exploring the Effects and Interactions of Conducting Polymers in the Volume Phase Transition of Thermosensitive Conducting Hydrogels

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(9), P. 4688 - 4702

Published: April 17, 2024

Conducting polymers (CPs) play a vital role in imparting electrochemical and photothermal properties to thermosensitive conducting hydrogels (TCH). The application of TCH is expanding not only for biomedical applications but also address water scarcity. While the volume phase transition (VPT) phenomenon has been extensively studied, contribution CPs this process underlying chemical interactions remain unclear low explored. In study, we present novel polymer hydrogel (CPH) utilizing poly(N-isopropylacrylamide) (PNIPAAm) enriched with poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles as model system. This serves platform both experimental theoretical investigations into influence on VPT. Through comprehensive examination responses temperature employing Raman spectroscopy, atomistic simulations using advanced hybrid methodologies, artificial intelligence, unveil shielding effect CP. arises from robust NIPAAm, inducing selective dehydration microenvironment. Remarkably, mirrors observed during VPT triggered by an increase temperature. Understanding intricate between imperative systematic development fine-tuning performance future CPHs. knowledge ensures more precise adaptation these materials their intended end applications.

Language: Английский

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Preparation and osteogenic properties of nano-hydroxyapatite/polyvinylidene fluoride/polyacrylamide/carboxymethyl cellulose piezoelectric double-network hydrogel soaked with metal ions

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 111911 - 111911

Published: Feb. 1, 2025

Language: Английский

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Polymers in Physics, Chemistry and Biology: Behavior of Linear Polymers in Fractal Structures

Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3400 - 3400

Published: Dec. 2, 2024

We start presenting an overview on recent applications of linear polymers and networks in condensed matter physics, chemistry biology by briefly discussing selected papers (published within 2022-2024) some detail. They are organized into three main subsections: physics (further subdivided simulations coarse-grained models structural properties materials), (quantum mechanical calculations, environmental issues rheological viscoelastic composites) (macromolecules, proteins biomedical applications). The core the work is devoted to a review theoretical aspects polymers, with emphasis self-avoiding walk (SAW) chains, regular lattices both deterministic random fractal structures. Values critical exponents describing structure SAWs different environments updated whenever available. case structures modeled percolation clusters at criticality, issue multifractality, which typical these complex systems, illustrated. Applications suggested, references known results literature provided. A detailed discussion reptation method its many interesting problem protein folding evolution also considered, key open questions highlighted. include experimental section introduces most relevant this work. last two sections dedicated applications, one materials science, such as features plasma-treated polymeric surfaces growth polymer thin films, second biology, considering among others long DNA, confined finite domain.

Language: Английский

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Reversibility of Swelling, pH Sensitivity, Electroconductivity, and Mechanical Properties of Composites Based on Polyacrylic Acid Hydrogels and Conducting Polymers

Journal of Composites Science, Journal Year: 2023, Volume and Issue: 7(6), P. 261 - 261

Published: June 20, 2023

Composites based on polyacrylic acid gels as matrices and conducting polymers (polyaniline polypyrrole) functional components have been obtained. It has shown that the dependence of equilibrium degree swelling pH medium for demonstrates its pronounced maximum at = 11. The reversibility processes swelling/contraction composites over a wide variation acidities was studied analyzed. effect crosslinking matrix content in determined. electric conductivity depended matrices, component measured. Deformational characteristics compression were measured prepared block-shaped cylinders. proven formation rigid-chain polymer phase led to an increase elastic modulus compared with one gel, but it did not cause noticeable decrease elasticity. observed new characterized by combination capacity, sensitivity, electroconductivity.

Language: Английский

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Graphene quantum dots in high performance nanocomposites—design to phantastic progressions

Materials Research Innovations, Journal Year: 2023, Volume and Issue: 28(4), P. 294 - 308

Published: Oct. 17, 2023

ABSTRACTThis comprehensive and novel article covers an important category of nanocomposites, i.e. polymer graphene quantum dots derived nanocomposites. Graphene have been found as remarkable zero-dimensional derivative having size up to 20 nm. Similar graphene, applied beneficial nano-reinforcement for the polymers. In this context, various conductive polymers (polypyrrole, polyaniline, polythiophene, etc.) thermoplastic (poly(vinyl alcohol), poly(vinyl fluoride), used matrices. Inclusion in matrices revealed superior structure, morphological, electronic, optical, photoluminescence, several other advantageous physical characteristics. Important application areas polymer/graphene nanomaterials observed solar cells, sensors, supercapacitors, batteries, memory devices, bioimaging. However, further research efforts desirable regarding modification exploration new nanocomposite designs sectors well overcoming related challenges future progressions nanocomposites.KEYWORDS: dotsconductive polymernanocompositessensorsolar cell Disclosure statementNo potential conflict interest was reported by authors.

Language: Английский

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Eco‐friendly electrosynthesis of Cu‐PANI‐pencil composite: Enhanced their current value, acid sensing, click chemistry and turn on‐off sunlight photo‐catalytical H2O2 activation

ChemSusChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

In this contribution, we report a straightforwardly and easily one-step synthesis of small family composites based in polyaniline grafted on HB2 graphite (PANI@UG) their copper-doped derivatives (Cu

Language: Английский

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