Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 26
Published: Dec. 15, 2024
The
implant
surface
chemistry
and
topography
are
primary
factors
regulating
the
success
survival
of
bone
scaffold.
Surface
modification
is
a
promising
alternative
to
enhance
biocompatibility
tissue
response
augment
osteogenic
functionalities
polyesters
like
PLA.
study
employed
synergistic
effect
alkaline
hydrolysis
polydopamine
(PDA)
functionalization
cell-material
interactions
on
3D
printed
polylactic
acid
(PLA)
Comprehensive
characterization
modified
PLA
highlights
improvements
in
physical,
chemical
upon
two-step
modification.
X-ray
photoelectron
spectroscopy
(XPS)
analysis
substantiated
enhanced
PDA
deposition
with
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
157, P. 106646 - 106646
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(2), P. 2791 - 2813
Published: Jan. 6, 2025
Transplantation
of
bone
implants
is
currently
recognized
as
one
the
most
effective
means
treating
defects.
Biobased
and
biodegradable
polyester
composites
combine
good
mechanical
degradable
properties
polyester,
thereby
providing
an
alternative
for
implant
materials.
Bone
tissue
engineering
(BTE)
accelerates
defect
repair
by
simulating
microenvironment.
Composite
scaffolds
support
formation
further
accelerate
process
repair.
The
introduction
3D
printing
technology
enables
preparation
to
be
more
precise,
reproducible,
flexible,
which
a
very
promising
development.
This
review
presents
physical
BTE
summarizes
strategies
adopted
domestic
international
scholars
improve
based
on
biobased
polyester/ceramic
in
recent
years.
In
addition,
future
development
prospects
field
challenges
expanding
production
clinical
applications
are
presented.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 1, 2025
ABSTRACT
This
investigation
aims
to
fabricate
scaffolds
consisting
of
gelatin/polylactic
acid/bredigite
composites
for
bone
tissue
regeneration.
In
this
regard,
porous
were
created
using
the
freeze–drying
technique.
To
determine
structure
and
assess
successful
synthesis
samples,
x‐ray
diffraction
(XRD)
Fourier
transform
infrared
(FTIR)
analyses
conducted.
The
morphological
properties
polymeric
bredigite
(0,
2.5,
5,
7.5
wt%)
incorporated
examined
field‐emission
scanning
electron
microscopy
(FE‐SEM).
evaluation
mechanical
revealed
that
addition
5
wt%
1Gel3PLA
scaffold
increased
compressive
strength
from
0.30–0.35
>
0.57
MPa.
Regarding
porosity,
decreasing
Gel:PLA
ratio
1:3
1:2
while
maintaining
constant
gelatin
content
porosity
58.3%
71.4%,
consistently
decreased
across
all
scaffolds.
in
vitro
bioactivity
assessment,
carried
out
simulated
body
fluid
(SBF),
demonstrated
formation
an
apatite
layer
on
surface
composite
after
immersion
SBF.
results
MTT
test
showed
as
amount
particles
wt%,
cell
viability
also
periods
(higher
than
90%
viability).
interaction
between
cells
was
by
culturing
human
osteoblastic
line
(MG‐63)
scaffolds,
revealing
a
higher
proliferation
deposition
minerals
bredigite‐containing
those
without
bredigite.
These
collectively
suggest
Gel‐PLA‐5
holds
promise
osteoconductive
material
applications
regenerating
tissue.
Advanced Engineering Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
This
review
aims
to
summarize
recent
advances
in
3D
printing
technologies
for
polymer‐based
bone
scaffolds,
focusing
on
material
applications
and
clinical
implications.
The
applicable
different
materials
are
discussed
with
their
characteristics
application
advantages,
specifically
the
common
techniques
polymer
used.
Recent
of
3D‐printed
scaffolds
multifunctionality
(i.e.,
drug
delivery,
regeneration
minimally
invasive
implantation)
then
presented
provide
guidance
potential
applications.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
20(1), P. 012001 - 012001
Published: Nov. 22, 2024
Abstract
Advancement
in
medicine
and
technology
has
resulted
into
prevention
of
countless
deaths
increased
life
span.
However,
it
is
important
to
note
that,
the
modern
lifestyle
altered
food
habits,
witnessed
life-style
stresses
road
accidents
leading
several
health
complications
one
primary
victims
bone
health.
More
often
than
ever,
healthcare
professionals
encounter
cases
massive
fracture,
loss
generation
critical
sized
defects.
Surgical
interventions,
through
use
grafting
techniques
are
necessary
such
cases.
Natural
grafts
(allografts,
autografts
xenografts)
however,
have
major
drawbacks
terms
delayed
rehabilitation,
lack
appropriate
donors,
infection
morbidity
that
shifted
focus
investigators
direction
synthetic
grafts.
By
employing
biomaterials
based
on
tissue
engineering
(BTE),
provide
a
more
biologically
acceptable
approach
establishing
phases
healing.
In
BTE,
various
materials
utilized
support
enhance
regeneration.
Biodegradable
polymers
like
poly-(lactic
acid),
poly-(glycolic
poly-(
ϵ
-caprolactone)
commonly
used
for
their
customizable
mechanical
properties
ability
degrade
over
time,
allowing
natural
growth.
PEG
employed
hydrogels
promote
cell
adhesion
Ceramics,
as
hydroxyapatite
beta-tricalcium
phosphate
(
β
-TCP)
mimic
mineral
attachment,
with
-TCP
gradually
resorbing
new
forms.
Composite
materials,
including
polymer-ceramic
polymer-glasses,
combine
benefits
both
ceramics/glasses
offer
enhanced
biological
properties.
collagen,
gelatin,
chitosan
matrix
attachment
formation,
also
offering
antimicrobial
Hybrid
decellularized
retain
structure
factors,
while
functionalized
scaffolds
incorporate
growth
factors
or
bioactive
molecules
further
stimulate
healing
integration.
The
current
review
article
provides
insights
could
yield
revolutionary
improvements
orthopedic
medical
fields.
introduction
section
this
focuses
statistical
information
requirements
globally
its
impact
economy.
later
section,
anatomy
human
bone,
defects
diseases
pertaining
limitations
were
detailed.
Biopolymers,
bioceramics,
biometals-based
discussed
depth
sections
followed.
then
concludes
summary
addressing
trends
future
prospects
potential
transplants.
