Mitigation of Experimental Hepatocellular Carcinoma by Inonotus obliquus Mushroom Extract in Association with Oxidative Stress and Inflammation Signaling DOI
Zaved Ahmad, Pir Mohammad Ishfaq, S. K. Jain

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: 114, P. 104648 - 104648

Published: Jan. 30, 2025

Language: Английский

Optimization of extraction condition to improve blackthorn (Prunus spinosa L.) polyphenols, anthocyanins and antioxidant activity by natural deep eutectic solvent (NADES) using the simplex lattice mixture design method DOI
Hyrije Koraqi, Alev Yüksel Aydar, R. Pandiselvam

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110497 - 110497

Published: April 6, 2024

Language: Английский

Citations

10
Extraction of Phycocyanin and Chlorophyll from Spirulina by “Green Methods” DOI Creative Commons
Krastena Nikolova, Nadezhda Petkova, Dasha Mihaylova

et al.

Separations, Journal Year: 2024, Volume and Issue: 11(2), P. 57 - 57

Published: Feb. 12, 2024

Phycocyanin is a pigment–protein complex from the group of phycobiliproteins obtained Spirulina (Arthrospira platensis), with possibilities for various applications in food and pharmaceutical technologies. It natural colorant cosmetic products. This study aimed to investigate effect ultrasonic microwave extraction conditions on antioxidant activity (AOA), chlorophyll content, content purity index phycocyanin aqueous alcoholic extracts platensis). For this purpose, water or ethanol was performed at 20 °C, 30 40 °C 1, 2, 3 h an frequency 36 kHz, 45 kHz. Microwave 60 s, 120 180 s. each samples, three parallel measurements were made by DPPH FRAP methods, yield determined spectrophotometrically. Ultrasonic resulted higher compared extraction. The highest 14.88 mg g−1 1.60 achieved temperature one hour wave A relatively low 4.21 g−1, but 2.67, time two hours, Chlorophyll b hours kHz 1.400 g−1. proposes as green method obtain varying that may be used food, cosmetic, biomedical purposes.

Language: Английский

Citations

9
Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation DOI Creative Commons
Fahad Hussain, Ayesha Tahir, Muhammad Saeed Jan

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10304 - 10321

Published: Jan. 1, 2024

Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD).

Language: Английский

Citations

9
Chitosan catechol-tannic acid composite hydrogel and cryogel with antimicrobial and hemostatic properties DOI

Liang-Jyun Huang,

Shih‐Ho Lin,

Tsai‐Yu Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132174 - 132174

Published: May 13, 2024

Language: Английский

Citations

9
A rapid and simplified DPPH assay for analysis of antioxidant interactions in binary combinations DOI Creative Commons
Fernando Silva, Francisco Veiga,

Catarina Cardoso

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 202, P. 110801 - 110801

Published: May 16, 2024

The study of synergistic and antagonistic antioxidant interactions is particularly important for pharmaceutical food industries. application methods like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay highly suited the quantification activity single compounds or plant extracts foods. However, studying interactions, these assays can become laborious time-consuming, since each pair combinations demands preparation several binary mixtures endowed with different combining concentrations. Consequently, generate large amounts data that need to be mathematically statistically treated specific commercial software. In our work, we propose a novel strategy shorten simultaneously number steps related treatment in interactions. To achieve this goal, were prepared using an adapted version checkerboard (two-dimensional microdilution) quantified, analyzed, presented free-web (SynergyFinder Plus). Particularly, studied interaction trehalose ascorbic acid, catechin, gallic quercetin. Our results show presents significant combination all four compounds. conclusion, first time SynergyFinder Plus has been used Hence, straightforward, efficient, accessible method was developed assess mixtures.

Language: Английский

Citations

9
Assessment of the antibacterial and antioxidant activities of seaweed-derived extracts DOI Creative Commons
Monika Hejna, Matteo Dell’Anno, Yanhong Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

Citations

9
Design and Synthesis of Pyridine Bis-Hydrazone Metal Complexes of Co(II), Cu(II), and Hg(II): Spectral, Gaussian, Electrochemical, Biological, Drug-Likeness and Molecular Docking Investigations DOI

Afnan I. Gomaa,

Esam A. Gomaa, Rania Zaky

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112188 - 112188

Published: Feb. 23, 2024

Language: Английский

Citations

8
Characterization of Phenolic Compounds from Moth Bean (Vigna aconitifolia) Seeds and Assessment of Prophylactic Potential in Terms of Antioxidant and Antihypertensive Activity DOI

Nancy Goyal,

Vanshika Adiani, Sachin N. Hajare

et al.

ACS Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

This study investigates the extraction, identification, and assessment of antioxidant antihypertensive potential soluble bound phenolics from moth bean. The yields were quantified as 0.15 ± 0.03 mg GAE/g 0.28 0.04 GAE/g, respectively. Overall, 9 major 15 identified crude fractions. Soluble exhibited higher (EC50: DPPH: 17.25 0.77; ABTS: 20.13 0.25; FRAP: 3.3 μg/mL) well a superior angiotensin converting enzyme (ACE) along with renin (IC50: 0.38; 2.3 μg/mL, respectively) inhibitory activity compared to phenolics. Notably, kaempferol displayed highest ACE inhibition via interacting key amino acids active site (His 387 Glu 411) Zn ion ACE, while gentisic acid by S1 pocket (Asp 32, Ser 76) renin. These findings highlight their therapeutic relevance in hypertension oxidative stress management.

Language: Английский

Citations

1
Deciphering antioxidant interactions via data mining and RDKit DOI Creative Commons
Lucas B. Ayres,

Justin T. Furgala,

Carlos D. García

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Minimizing the oxidation of lipids remains one most important challenges to extend shelf-life food products and reduce waste. While consumer contain antioxidants, efficient strategy is incorporate combinations two or more compounds, boosting total antioxidant capacity. Unfortunately, reasons for observing synergistic / antagonistic additive effects in samples are still unclear, it common observe very different responses even similar mixtures. Aiming identify chemical features that can be correlated with specific responses, this report presents an analysis 1243 mixtures antioxidants reported literature. The focuses on commonly compounds considers how various descriptors (number atoms, number heavy heteroatoms, carbon oxygen nitrogen chloride polar surface area, molecular weight, aromatic rings, logP, hydrogen bond counts) affect response. Out those, our showed bonding plays role determining interact, potentially affecting overall behavior Far from drawing a universal conclusion about particular mechanism; article provides overview what has worked so far, delving into possible variables behind those interactions.

Language: Английский

Citations

1
Impact of dietary mulberry (Morus alba) fruit extract on the growth performance, skin color, and immune response of fancy carp (Cyprinus carpio) DOI
Wassana Prisingkorn,

Prasob‐orn Rinthong,

Narong Kamolrat

et al.

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 40, P. 102611 - 102611

Published: Jan. 5, 2025

Language: Английский

Citations

1