Assessing water quality of River Mahananda, Malda, India using Cirrhinus reba as a bioindicator: Oxidative stress biomarkers and histopathological fingerprints

Environmental Monitoring and Assessment, Journal Year: 2025, Volume and Issue: 197(5)

Published: April 9, 2025

Language: Английский

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Environmental contaminants and insects: Genetic strategies for ecosystem and agricultural sustainability

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 982, P. 179660 - 179660

Published: May 17, 2025

Language: Английский

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Expression of Antimicrobic Peptide Piscidin1 in Gills Mast Cells of Giant Mudskipper Periophthalmodon schlosseri (Pallas, 1770)

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 13707 - 13707

Published: Nov. 8, 2022

The amphibious teleost Giant mudskipper (Periophthalmodon schlosseri, Pallas 1770) inhabit muddy plains and Asian mangrove forests. It spends more than 90% of its life outside the water, using skin, gills, buccal-pharyngeal cavity mucosa to breathe in oxygen from surrounding air. All vertebrates have been found mast cells (MCs), which are part innate immune system. These mostly mucous membranes organs that come contact with environment. According their morphology, MCs distinctive cytoplasmic granules released during degranulation process. Additionally, these antimicrobial peptides (AMPs) fight a variety infections. Piscidins, hepcidins, defensins, cathelicidins, histonic examples fish AMPs. Confocal microscopy was used this study assess Piscidin1 expression Mudskipper branchial MCs. Our results demonstrated presence gills is highly positive for Piscidin1. colocalized labeled TLR2/5-HT Piscidin1/5-HT supported our data. giant highlights involvement peptide orchestration immunity, advancing knowledge defense system fish.

Language: Английский

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Localization of Acetylcholine, Alpha 7-NAChR and the Antimicrobial Peptide Piscidin 1 in the Macrophages of Fish Gut: Evidence for a Cholinergic System, Diverse Macrophage Populations and Polarization of Immune Responses

Fishes, Journal Year: 2023, Volume and Issue: 8(1), P. 43 - 43

Published: Jan. 8, 2023

The recognition and elimination of invading pathogens are vital for host survival. Macrophages play a central role in protection cells functionally reminiscent vertebrate macrophages present all multicellular organisms. A pattern responsible bacterial found on the surface is CD14. These possess repertoire antimicrobial molecules stored their granules lysosomes. Polarization states observed mammalian termed M1 M2 also likely exist fish macrophages. Markers macrophage subtypes slowly but definitively emerging species. In study cell markers such as CD14, acetylcholine, alpha 7 acetylcholine nicotinic receptor (nAChR) subtype, inducible nitric oxidase synthase (iNOS), peptide piscidin 1 reported first time intestinal both catfish Heteropneustes fossilis (Bloch, 1794) African bonytongue Heterotis niloticus (Cuvier, 1829) along anterior posterior axis concentric muscle layers. Many effector responses including respiratory burst NO induction similar across diverse animal taxa. Antibodies against calbindin coupled with ones to VAChT tubulin revealed localization myenteric submucosal plexuses, which made up enteric neurons, glial cells, nerves near Current studies allow elucidation multiple roles disease models providing an insight into vivo function fish.

Language: Английский

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Shell formation in two species of bivalves: the role of mantle cells and haemocytes

Zoological Journal of the Linnean Society, Journal Year: 2023, Volume and Issue: 200(4), P. 980 - 993

Published: Sept. 7, 2023

Abstract The shell of bivalves acts as structural support, defence against predators, stressors, and maintenance homeostasis. Haemocytes mantle epithelial cells participate in formation. Mantle produce the organic matrix are associated with biomineralization because their proximity to surface ability maintain deposition ex vivo. play an immunological role involved Ca2+ CO32- intracellular transport implicated mineralization. This study aims evaluate expression molecules that key roles internal nervous system, haemocytes outer margin two species bivalves, Polititapes aureus Gmelin, 1791 Cerastoderma glaucum Bruguière, 1789, highlight collaborative Our data show for first time presence serotonin/S100 protein, TLR2/iNOS colocalization P. C. glaucum, suggesting perform canonical sensory biomineralizing activity, while typical immune function, collaboration formation, providing new information on cellular interactions formation giving more details taxonomical studies.

Language: Английский

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Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2534 - 2534

Published: June 18, 2022

The immune system is highly dynamic and susceptible to many alterations throughout pregnancy. Since December 2019, a pandemic caused by coronavirus disease 19 (COVID-19) has swept the globe. To contain spread of COVID-19, immediate measures such as quarantine isolation were implemented. These containment have contributed exacerbate situations anxiety stress, especially in pregnant women, who are already particularly anxious about their condition. Alterations psychological state women related system, which more vulnerable under stress. COVID-19 could therefore find fertile soil these individuals risk severe forms. Normally controlled dietary regimen followed during pregnancy, but use particular vitamins micronutrients can help counteract depressive-anxiety states improve provide an additional weapon defense against bring pregnancy fruition. This review aims gather data on impact condition assess whether some psychophysical symptoms.

Language: Английский

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Immunogenicity, effectiveness, safety and psychological impact of COVID-19 mRNA vaccines

Human Immunology, Journal Year: 2022, Volume and Issue: 83(11), P. 755 - 767

Published: Aug. 8, 2022

Language: Английский

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Investigating the internal system of defense of Gastropoda Aplysia depilans (Gmelin, 1791): Focus on hemocytes

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 137, P. 108791 - 108791

Published: May 3, 2023

The internal defense system of mollusks represents an efficient protection against pathogens and parasites, involving several biological immune processes, such as phagocytosis, encapsulation, cytotoxicity, antigenic recognition self/non-self. Mollusks possess professional, migratory, circulating cells that play a key role in the organism, hemocytes. Several studies have been performed on hemocytes from different mollusks, but, to date, these are still scarcely explored. Different hemocyte populations found, according presence or absence granules, size, species studied. Our study aims deepen knowledge gastropod Aplysia depilans using morphological techniques light confocal microscopy, testing Toll-like receptor 2, inducible nitric oxide synthetase, nicotinic acetylcholine alpha 7 subunit. results show two distinguishable by presence/absence granules cytoplasm, strongly positive for antibodies tested, suggesting first time receptors surface sea hare immunohistochemistry. These data help understanding this gastropod, providing additional comprehending evolution response metazoan phylogenesis.

Language: Английский

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Perfluorooctanoic Acid Promotes Recruitment and Exocytosis of Rodlet Cells in the Renal Hematopoietic Tissue of Common Carp

Toxics, Journal Year: 2023, Volume and Issue: 11(10), P. 831 - 831

Published: Sept. 30, 2023

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants, with perfluorooctanoic acid (PFOA) being a prominent member. PFOA poses risk to aquatic ecosystems human health due its presence in water, persistence, bioaccumulation. Since rodlet cells (RCs) have emerged as potential biomarkers for chemical stressors, this study aimed investigate the effects of sub-chronic exposure on RCs renal hematopoietic tissue common carp. Three groups fish were used: an unexposed control group two exposed environmentally relevant (200 ng L−1) elevated (2 mg concentrations. Light transmission electron microscopy employed assess RCs’ distribution patterns exocytosis, while biometry quantified tissue. The results showed that, even at concentrations, significantly influenced patterns, leading increased occurrence cluster formation, well heightened exocytosis activity. This research highlights PFOA’s immunotoxicity suggests sentinel immunological response contaminants. These findings enhance our understanding PFAS toxicity emphasise importance monitoring their impact representative vertebrates reliable animal models.

Language: Английский

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Toxic Effects of Carbaryl Exposure on Juvenile Asian Seabass (Lates calcarifer)

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(3), P. 923 - 938

Published: July 10, 2024

This study examines the physiological and immunological effects of 0.5 ppm carbaryl exposure on juvenile Asian seabass (Lates calcarifer) over 12 h to 72 h. Notable results include decreased activities liver enzymes catalase (CAT), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-PX), while superoxide dismutase (SOD) levels remained stable, with lowest CAT GSH-PX observed at Serum biochemistry revealed increased alkaline phosphatase (AKP) acid (ACP) 24 h, declining aspartate aminotransferase (AST) a peak in creatinine 48 Histopathological analysis showed carbaryl-induced necrosis spleen cells, melanomacrophage centers both organs. Additionally, immune gene expression indicated an upregulation heat shock proteins consistent elevation complement component C3 interleukin-8 (IL-8). These findings suggest that significantly impairs organ function modulates responses L. calcarifer, underlining need for further research protective strategies against pesticide impacts aquaculture.

Language: Английский

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