Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 866, P. 161258 - 161258

Published: Dec. 30, 2022

In Asian developing countries, undeveloped and ineffective sewer systems are causing surface water pollution by a lot of contaminants, especially pharmaceuticals personal care products (PPCPs). Therefore, the risks for freshwater fauna need to be assessed. The present study aimed at: i) elucidating contamination status; ii) evaluating bioaccumulation; iii) assessing potential PPCP residues in fish from three countries. We measured 43 PPCPs plasma several species as well ambient samples collected India (Chennai Bengaluru), Indonesia (Jakarta Tangerang), Vietnam (Hanoi Hoa Binh). addition, validity existing blood-water partitioning model based solely on lipophilicity chemicals is assessed ionizable readily metabolizable PPCPs. When comparing bioaccumulation factors calculated concentrations (BAFmeasured) with bioconcentration predicted their pH-dependent octanol-water partition coefficient (BCFpredicted), close values (within an order magnitude) were observed 58-91 % detected compounds. Nevertheless, up 110 times higher BAFmeasured than BCFpredicted found antihistamine chlorpheniramine tilapia but not other species. compound significantly different (tilapia > carp catfish), possibly due species-specific differences toxicokinetics (e.g., protein binding hepatic metabolism). Results risk evaluation suggested that chlorpheniramine, triclosan, haloperidol, triclocarban, diclofenac, diphenhydramine can pose adverse effects wild fish. indicated high ecological carbamazepine, sulfamethoxazole, erythromycin, triclosan ecosystems.

Language: Английский

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Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(24), P. 8845 - 8862

Published: June 8, 2023

The increasing levels and frequencies at which active pharmaceutical ingredients (APIs) are being detected in the environment of significant concern, especially considering potential adverse effects they may have on nontarget species such as fish. With many pharmaceuticals lacking environmental risk assessments, there is a need to better define understand risks that APIs their biotransformation products pose fish, while still minimizing use experimental animals. There both extrinsic (environment- drug-related) intrinsic (fish-related) factors make fish potentially vulnerable human drugs, but not necessarily captured nonfish tests. This critical review explores these factors, particularly focusing distinctive physiological processes underlie drug absorption, distribution, metabolism, excretion toxicity (ADMET). Focal points include impact life stage absorption (A) via multiple routes; implications fish's unique blood pH plasma composition distribution (D) molecules throughout body; how endothermic nature varied expression activity drug-metabolizing enzymes tissues affect metabolism (M); physiologies relative contribution different excretory organs (E) metabolites. These discussions give insight into where existing data properties, pharmacokinetics pharmacodynamics from mammalian clinical studies or help inform

Language: Английский

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Fate of pharmaceuticals in the Ebro River Delta region: The combined evaluation of water, sediment, plastic litter, and biomonitoring

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167467 - 167467

Published: Sept. 29, 2023

Language: Английский

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Effects of common antiepileptic drugs on teleost fishes

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 866, P. 161324 - 161324

Published: Jan. 4, 2023

Language: Английский

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Assessment of wastewater-borne pharmaceuticals in tissues and body fluids from riverine fish

Environmental Pollution, Journal Year: 2023, Volume and Issue: 324, P. 121374 - 121374

Published: Feb. 27, 2023

Riverine fish in densely populated areas is constantly exposed to wastewater-borne contaminants from effluent discharges. These can enter the organism through skin, gills or by ingestion. Whereas most studies assessing contaminant burden have focused either on muscle a limited set of tissues. Here we out generate more comprehensive overview distribution pollutants across tissues analyzing panel matrices including liver, kidney, brain, muscle, heart, plasma and bile. To achieve broad analyte coverage with minimal bias towards specific class, sample extracts four species were analyzed High-Performance Liquid Chromatography (HPLC) - high-resolution mass spectrometry (HRMS) for presence 600 pharmaceutically active compounds (PhACs) known environmental relevance river water suspect-screening analysis. A total 30 detected suspect screening at least one clear prevalence antidepressants. Of these, 15 confidence level 2.a (Schymanski scale), 1 following confirmation authentic standards, which furthermore enabled their quantification. The PhACs confirmed included acridone, acetaminophen, caffeine, clarithromycin, codeine, diazepam, diltiazem, fluoxetine, ketoprofen, loratadine, metoprolol, sertraline, sotalol, trimethoprim, venlafaxine. Among these substances, sertraline stood as it displayed highest detection frequency. values tissue partition coefficients brain correlated its physicochemical properties. Based inter-matrix comparison frequencies, skin heart should be biomonitoring riverine fish.

Language: Английский

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Sub-chronic exposure to paroxetine disrupts ecologically relevant behaviours in fish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170405 - 170405

Published: Jan. 26, 2024

The functional conservation of important selective serotonin reuptake inhibitor (SSRI) targets in non-target organisms raises concerns about their potential adverse effects on the ecosystems. Although environmental levels SSRIs like paroxetine (PAR) have risen, knowledge regarding long-term exposure to PAR is limited. This study investigated impact sub-chronic (21 days) two sub-lethal concentrations (40 and 400 μg/L) behaviour adult zebrafish different scenarios: basal activity (under dark light conditions), stress response (evoked by sudden transitions) recovery. A new framework was employed for integrative fish's swimming performance based innate ability respond shifts. Several swimming-associated parameters (e.g., total distance, time inactivity, angles) thigmotaxis were monitored an integrated analysis each scenario. Data revealed reduced activity, impaired behavioural alterations recovery PAR-exposed fish. An anxiolytic effect particularly noticeable fish at μg/L (from light) dark) exposed 40 μg/L. detected PAR-induced modifications suggest a disruption brain glucocorticoid signalling that may implications individual level changing responses predators), with repercussions population community levels. Therefore, applied protocol proved sensitive detecting changes induced PAR.

Language: Английский

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Behavioural responses of fishes to anthropogenic disturbances: Adaptive value and ecological consequences

Journal of Fish Biology, Journal Year: 2023, Volume and Issue: 103(4), P. 773 - 783

Published: Jan. 17, 2023

Aquatic ecosystems are changing at an accelerating rate because of human activities. The changes alter the abundance and distribution fishes, with potential consequences for ecosystem structure function. Behavioural responses often underlie these in population dynamics, such as altered habitat choice or foraging activity. Here, we present a framework understanding how why behaviour is affected by activities behavioural turn influence higher ecological levels. We further review literature to assess state field identify gaps our knowledge. begin discussing factors that determine individual responds change environment whether response adaptive not. In particular, explain importance evolutionary history species. then search current knowledge impact disturbances on fishes ecosystems. reveals much attention has been directed but worryingly little known about populations, communities Yet, can have profound given underly many, if not most, species interactions. Thus, more should be paid mechanisms pathways through which Such information needed ultimate effects biodiversity function stability aquatic

Language: Английский

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Predicting the potential risks posed by antidepressants as emerging contaminants in fish based on network pharmacological analysis

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: 99, P. 105872 - 105872

Published: June 6, 2024

Language: Английский

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Pharmaceuticals in the Aquatic Environment: No Answers Yet to the Major Questions

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 43(3), P. 589 - 594

Published: June 30, 2022

Abstract The presence of pharmaceuticals in the environment, especially aquatic has received a lot attention last 20 plus years. Despite that attention, two most important questions regarding environment still cannot be answered. It is not possible to put threat posed by into perspective with many other threats (stressors) facing organisms, such as low flows due over‐abstraction water, inhibited passage migratory species dams and weirs, diseases, algal blooms causing oxygen levels releasing toxins, eutrophication, climate change, so on. Nor it identify which are concern not. Not only can these key answered presently, they have extremely little despite being identified 10 years ago answer. That situation must change if resources expertise effectively used protect environment. Environ Toxicol Chem 2024;43:589–594. © 2022 Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC on behalf SETAC.

Language: Английский

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Biological-Activity-Based Prioritization of Antidepressants in Wastewater in England and Japan

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(16), P. 6444 - 6454

Published: April 6, 2023

Antidepressants are one of the most commonly prescribed pharmaceuticals. Although they have been frequently detected in aquatic environments around globe, little is known regarding their adverse effects on humans and organisms. Recently, an vitro monoamine transporter inhibition assay was developed to detect transporter-inhibitory activities antidepressants wastewater Japan. However, it unclear which were responsible for wastewater. Herein, per capita consumption 32 antidepressants, excretion unchanged parent compounds, water consumption, removal rate during treatment processes, potency values from used prioritize concern effluent England In both countries, sertraline O-desmethylvenlafaxine had highest contribution inhibitory against human serotonin (hSERT) zebrafish SERT (zSERT), respectively. It found that inhibited zSERT more strongly than hSERT. The Japan higher thresholds abnormal behavior fish. prioritized this study provide insight into launching environmental monitoring ecotoxicological studies antidepressants.

Language: Английский

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