The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset DOI Creative Commons
Jun-feng Nie,

Dengqiu Lu,

Cong Zhang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

Abstract Background: Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect SII on association between metals and total fat (TOFAT). We aim to investigate mediated relationship urinary TOFAT in US adult population. Methods: This cross-sectional study was conducted among adults with complete information SII, urine metal concentrations, from 2011-2018 National Health Nutrition Examination Survey (NHANES). Multifactorial logistic regression restricted cubic splines were used explore levels TOFAT. Furthermore, serial mediation analyses mediating Results: A 3324 subjects included this study. After adjusting for covariates, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), antimony (Sb) had negative significant decreased trends odds ratios (all P trend < 0.05). In population, we found that Cd, Co, Tu positive [ β = 34.67 (95%CI: 1.65, 67.70); 54.49 12.20, 96.78); 29.46 1.67, 57.24)], whereas As Hg SII. The results analysis showed effects associations Co TOFAT, beta coefficient 0.8% 0.2, 0.5%; 0.020). not statistically As, > Conclusions: Our findings suggested exposure would directly decrease level increase completely by which mainly exerted females rather than males.

Language: Английский

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population DOI Creative Commons
Linhai Zhao, Yanfei Wei, Qiumei Liu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 29, 2024

Exposure to heavy metals alone or in combination can promote systemic inflammation. The aim of this study was investigate potential associations between multiple plasma and markers immune

Language: Английский

Citations

7
Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among U.S. adults DOI
Yalan Liu,

Zhaofeng Jin,

Shihao Fu

et al.

BioMetals, Journal Year: 2024, Volume and Issue: 37(5), P. 1279 - 1288

Published: May 31, 2024

Language: Английский

Citations

4
The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female DOI Creative Commons
Jun-feng Nie,

Zhumin Hu,

Cuiyao Xian

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 15, 2024

Studies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored relationship co-exposure Cd, Co, Pb, PAHs, SII.

Language: Английский

Citations

3
Interplay and long-lasting effects of maternal low-level Pb, Hg, and Cd exposures on offspring cognition DOI Creative Commons

Lu Ouyang,

Qi Li, Shuo Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117315 - 117315

Published: Nov. 1, 2024

Lead (Pb), mercury (Hg), and cadmium (Cd) are prevalent persistent environmental contaminants, causing detrimental effects on millions of individuals worldwide. Our previous research demonstrated that early-life exposure to low-level Pb, Hg, Cd mixtures may lead cognitive impairments. However, the association interaction among low levels or remains unclear. In this study, a two-level full factorial design (5.481, 0.036, 2.132 mg/L for respectively) was conducted assess interplay maternal offspring cognition. Following during pregnancy lactation, competitive absorption observed. Maternal each metal alone resulted in higher blood brain concentrations compared co-exposure at equivalent levels. behavioral experiments Morris water maze novel object recognition test revealed synergistically impaired offspring's spatial cognition memory. Importantly, dysfunction persisted into middle age even without after adulthood. Moreover, open field elevated plus indicated triggered risk-taking behavior weaning offspring, with significant main effect Pb exposure. No long-lasting detected middle-aged offspring. Further investigation molecular mechanisms showed dysregulation corticosterone reaction immune response might be potential mechanism underlying co-exposure-induced study highlights synergistic multiple heavy exposures,underscoring urgency prevent children women childbearing age.

Language: Английский

Citations

3
Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults DOI Creative Commons
Xinliang Zheng,

Wenxin Zhou,

Zhuoying Jiang

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 237 - 237

Published: March 24, 2025

α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on levels remains unclear. This study investigated the relationship between urinary concentrations serum using data from National Health Nutrition Examination Survey (NHANES) 2007–2016 cycles. A total of 4071 adults aged 40 79 years were included in analysis. After adjusting for potential confounders, positive associations found barium (Ba), cesium (Cs), molybdenum (Mo), while tungsten (W) uranium (U) negatively correlated levels. The combined effects multiple metals further analyzed qgcomp model, which demonstrated a negative correlation increased mixtures Specifically, U, arsenic (t-As), W, cadmium (Cd), antimony (Sb), lead (Pb) contributed reduction levels, Ba, Cs, dimethylarsinic acid (DMA), Mo, thallium (Tl), cobalt (Co) positively These findings suggest that certain metals, particularly combination, may reduce potentially accelerating aging processes. Further studies should investigate underlying mechanisms responsible these associations.

Language: Английский

Citations

0
Blood Cadmium Levels and Overactive Bladder in Middle-Aged and Older Adults in the United States: Insights from NHANES 2007–2020 Data DOI
Fan Gao, Lu Yin, Qiang Cheng

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125148 - 125148

Published: Oct. 1, 2024

Language: Английский

Citations

2
The Mechanisms of Cadmium Toxicity in Living Organisms DOI Creative Commons

Slavena Davidova,

Viktor Mihailov Milushev,

Galina Satchanska

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 875 - 875

Published: Nov. 30, 2024

Cadmium (Cd) is a toxic metal primarily found as by-product of zinc production. Cd was proven carcinogen, and exposure to this has been linked various adverse health effects, which were first reported in the mid-19th century thoroughly investigated by 20th century. The toxicokinetics dynamics reveal its propensity for long biological retention predominant storage soft tissues. Until 1950s, pollution caused industrial activities, whereas nowadays, main source phosphate fertilizers, strongly contaminate soil water affect human ecosystems. enters body mainly through ingestion inhalation, with food tobacco smoke being primary sources. It accumulates organs, particularly kidney liver, known cause severe problems, including renal dysfunction, bone diseases, cardiovascular many others. On cellular level, disrupts numerous processes, inducing oxidative stress generation DNA damage. This comprehensive review explores pollution, accumulation, distribution, impacts on bacteria, fungi, edible mushrooms, plants, animals, humans molecular level. Molecular aspects carcinogenesis, apoptosis, autophagy, specific gene expression, protein synthesis, ROS formation discussed well. paper also summarizes how removed from contaminated environments body.

Language: Английский

Citations

2
Effect of blood lead levels on periodontitis in American adults: a cross-sectional analysis from the national health and nutrition examination survey DOI Creative Commons

Tangye Dai,

Qun Dai

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 21, 2024

The primary objective of this study was to assess the impact blood lead levels on development and progression periodontitis.

Language: Английский

Citations

1
Association of Metal Exposure with Novel Immunoinflammatory Indicators DOI Creative Commons
Lingxiao Zhao, Xieyi Chen, Zhongwen Chen

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 316 - 316

Published: April 26, 2024

Objective: We aimed to investigate the relationship between metal exposure and novel immunoinflammatory indicators. Methods: Data on adults participating in National Health Nutrition Examination Survey (NHANES) from 2009 2018 were analyzed. Various statistical models employed assess association immune-inflammation-related Additionally, impact of inflammation different gender populations was explored. Results: This study included 4482 participants, whom 51.1% male. Significant correlations observed among various metals. Both elastic net (ENET) linear regression revealed robust associations cadmium (Cd), cobalt (Co), arsenic (As), mercury (Hg), Weighted quantile sum (WQS) Quantile g-computation (Q-gcomp) demonstrated strong barium (Ba), Co, Hg Bayesian kernel machine (BKMR) analysis indicated an overall positive correlation vivo urinary levels systemic response index (SIRI) aggregate (AISI). Furthermore, As, emerged as key metals contributing changes Conclusions: Metals exhibit with emerging indicators, concurrent mixed may exacerbate inflammatory response. this varies across populations.

Language: Английский

Citations

1
The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset DOI Creative Commons
Weipeng Zhang, Cong Zhang,

Dengqiu Lu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 28, 2024

Abstract Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect SII on association between metals and total fat (TOFAT). We aim to investigate mediated relationship urinary TOFAT in US adult population. This cross-sectional study was conducted among adults with complete information SII, urine metal concentrations, from 2011–2018 National Health Nutrition Examination Survey (NHANES). Multifactorial logistic regression restricted cubic splines were used explore levels TOFAT. Furthermore, serial mediation analyses mediating A 3324 subjects included this study. After adjusting for confounders, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), antimony (Sb), thallium(Tl) had negative decreased trends odds ratios (all P trend < 0.05). In population, we found that Cd, Co, Tu positively associated ( β = 29.70, 79.37, 31.08), whereas As Hg SII. The analysis showed Co TOFAT, being 0.9% (95%CI: 0.3%, 1.6%). Our findings suggested exposure As, would directly decrease level increase completely by mainly exerted females rather than males.

Language: Английский

Citations

1