Characterization of SARS-CoV-2 Variants in Military and Civilian Personnel of an Air Force Airport during Three Pandemic Waves in Italy

Microorganisms, Journal Year: 2023, Volume and Issue: 11(11), P. 2711 - 2711

Published: Nov. 5, 2023

We investigated SARS-CoV-2 variants circulating, from November 2020 to March 2022, among military and civilian personnel at an Air Force airport in Italy order classify viral isolates a potential hotspot for virus spread. Positive samples were subjected Next-Generation Sequencing (NGS) of the whole genome Sanger sequencing spike coding region. Phylogenetic analysis classified traced their evolutionary relationships. Clusters identified using 70% cut-off. methods yielded comparable results terms variant classification. In 2021, we several variants, including B.1.258 (4/67), B.1.177 (9/67), Alpha (B.1.1.7, 9/67), Gamma (P.1.1, 4/67), Delta (4/67). only Omicron its sub-lineage observed (37/67). screened detect naturally occurring resistance genomic regions, target new therapies, comparing them Wuhan Hu-1 reference strain. Interestingly, 2/30 non-Omicron carried G15S 3CLpro substitution responsible reduced susceptibility protease inhibitors. On other hand, unusual substitutions A1803V, D1809N, A949T on PLpro, D216N 3CLpro. Finally, P323L RdRp regions was not associated with mutational pattern related polymerase inhibitor resistance. This study highlights importance continuous surveillance monitor evolution general population, as well restricted communities.

Language: Английский

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Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 8, 2023

Abstract While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report dynamics lineages March 2020 to 2022 in Cameroon. Of 760 whole-genome sequences successfully generated by national genomic surveillance network, 74% were viral sub-lineages origin and non-variants concern, 15% Delta, 6% Omicron, 3% Alpha 2% Beta variants. The pandemic was driven wave 1 (16 weeks, 2.3% CFR), variants 2 (21 1.6% Delta 3 (11 2.0% omicron 4 (8 0.73% with declining trend over time (p = 0.01208). Even though heterogeneity did not seemingly contribute breadth transmission, especially appeared as drivers COVID-19 severity

Language: Английский

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Global Emergence of SARS-CoV2 Infection and Scientific Interventions to Contain its Spread

Current Protein and Peptide Science, Journal Year: 2024, Volume and Issue: 25(4), P. 307 - 325

Published: Jan. 24, 2024

Abstract: The global pandemic caused by COVID-19 posed a significant challenge to public health, necessitating rapid scientific interventions tackle the spread of infection. review discusses key areas research on including viral genomics, epidemiology, pathogenesis, diagnostics, and therapeutics. genome sequencing virus facilitated tracking its evolution, transmission dynamics, identification variants. Epidemiological studies have provided insights into disease spread, risk factors, impact health infrastructure social distancing measures. Investigations pathogenesis elucidated mechanisms underlying immune responses severe manifestations long-term effects COVID-19. Overall, article provides an updated overview diagnostic methods developed for SARS-CoV-2 their strengths, limitations, appropriate utilization in different clinical settings. Furthermore, therapeutic approaches antiviral drugs, immunomodulatory therapies, repurposed medications been investigated alleviate severity improve patient outcomes. Through comprehensive analysis these efforts, advancements made understanding tackling SARS-CoV-2, while underscoring need continued address evolving challenges this crisis.

Language: Английский

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The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients

Prostaglandins & Other Lipid Mediators, Journal Year: 2023, Volume and Issue: 169, P. 106770 - 106770

Published: Aug. 24, 2023

Language: Английский

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To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals

Scandinavian Journal of Immunology, Journal Year: 2023, Volume and Issue: 99(2)

Published: Dec. 6, 2023

Abstract COVID‐19 disease has plagued the world economy and affected overall well‐being life of most people. Natural infection as well vaccination leads to development an immune response against pathogen. This involves production antibodies, which can neutralize virus during future challenges. In addition, cellular memory with B T cells provides long‐lasting protection. The longevity been a subject intensive research in this field. extent immunity conferred by different forms or natural infections remained debatable for long. Hence, understanding effectiveness these responses among groups people assist government organizations making informed policy decisions. article, based on publicly available data, we have reviewed generated some vaccines SARS‐CoV‐2 its variants, particularly cell individuals.

Language: Английский

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The Relationship between the Transmission of Different SARS-CoV-2 Strains and Air Quality: A Case Study in China

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 1943 - 1943

Published: Jan. 20, 2023

Coronavirus Disease 2019 (COVID-19) has been a global public health concern for almost three years, and the transmission characteristics vary among different virus variants. Previous studies have investigated relationship between air pollutants COVID-19 infection caused by original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, it is unclear whether individuals might be more susceptible to due exposure pollutants, with SARS-CoV-2 mutating faster faster. This study aimed explore major strains (the strain, Delta variant, Omicron variant) in China. A generalized additive model was applied investigate associations six (PM2.5, PM10, SO2, CO, NO2, O3). positive correlation indicated NO2) confirmed cases strains. It also suggested that mutant variants appear closely associated than strain. could provide valuable insight into control strategies limit concentration at lower levels would better spread even as continues mutate.

Language: Английский

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Coping with the COVID-19 pandemic: A cross-sectional study to investigate how mental health, lifestyle, and socio-demographic factors shape students’ quality of life

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(7), P. e0288358 - e0288358

Published: July 20, 2023

The high prevalence of COVID-19 has had an impact on the Quality Life (QOL) people across world, particularly students. purpose this study was to investigate social, lifestyle, and mental health aspects that are associated with QOL among university students in Lebanon.A cross-sectional design implemented using a convenience sampling approach. Data collection took place between November 2021 February 2022, involving 329 undergraduate graduate from private public universities. life assessed Quality-of-Life Scale (QOLS). Descriptive statistics, Cronbach's alpha, linear regression-based methods were used analyze association socio-demographic, health-related, factors. significance level for statistical analysis predetermined at α = 0.05.The participants' average (SD) score 76.03 (15.6) Cronbach alpha 0.911. positively importance religion daily decisions (β 6.40, p 0.006), household income 5.25, 0.017), general ratings Excellent/poor 23.52, <0.001), access counseling 4.05, 0.020), physical exercise 6.67, healthy diet 4.62, 0.026); negatively cigarette smoking increased -6.25, 0.030), internet use ≥4 hours -7.01, 0.005), depression -0.56, 0.002) stress -0.93, <0.001).In conclusion, reveals key factors influence students' quality (QOL). Factors such as religion, higher income, improve QOL, while depression, stress, excessive use, it. Universities should prioritize initiatives like activity promotion, affordable nutritious options, destigmatizing health, services, self-help interventions support student well-being enhance their QOL.

Language: Английский

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Complexity and Diversity of the Neurological Spectrum of SARS-CoV-2 over Three Waves of COVID-19

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3477 - 3477

Published: June 14, 2024

Background/Objectives: SARS-CoV-2 continually mutates, with five identified variants. Many neurological manifestations were observed during the COVID-19 pandemic, differences between virus The aim of this study is to assess frequency and characteristics in hospitalized patients over three waves Poland comparison analysis correlation course infection. Methods: This retrospective single-center included 600 consecutive adults confirmed COVID-19, 3 (pre-Delta, Delta Omicron) Poland. Demographic clinical information collected compared across periods. Results: median age group was 68, lower wave. In Omicron period, disease severity at admission inflammatory markers concentration lowest. Neurological 49%. most common altered mentation, headache, myalgia, mood disorder, ischemic stroke encephalopathy. Smell taste disturbances (STDs) less frequent period. complications predominant pre-Delta Ischemic more often Altered mentation related higher admission, worse lab test results, ICU mortality, while headache reduced mortality. Pre-existing dementia Conclusions: are frequent, a rate STDs period cerebrovascular diseases Headache improves comorbidities increase

Language: Английский

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Molecular Characterization and Cluster Analysis of SARS-CoV-2 Viral Isolates in Kahramanmaraş City, Turkey: The Delta VOC Wave within One Month

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 802 - 802

Published: March 21, 2023

The SARS-CoV-2 pandemic has seriously affected the population in Turkey. Since beginning, phylogenetic analysis been necessary to monitor public health measures against COVID-19 disease. In any case, of spike (S) and nucleocapsid (N) gene mutations was crucial determining their potential impact on viral spread. We screened S N regions detect usual unusual substitutions, whilst also investigating clusters among a patient cohort resident Kahramanmaraş city, restricted time span. Sequences were obtained by Sanger methods genotyped PANGO Lineage tool. Amino acid substitutions annotated comparing newly generated sequences NC_045512.2 reference sequence. Clusters defined using with 70% cut-off. All classified as Delta. Eight isolates carried protein, some them located S2 key domain. One isolate displayed L139S while few T24I A359S able destabilize protein. Phylogeny identified nine monophyletic clusters. This study provided additional information about epidemiology Turkey, suggesting local transmission infection city several routes, highlighting necessity improve power sequencing worldwide.

Language: Английский

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The lead time and geographical variations of Baidu Search Index in the early warning of COVID-19

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 7, 2023

Internet search data was a useful tool in the pre-warning of COVID-19. However, lead time and indicators may change over space with new variants appear massive nucleic acid testing. Since Omicron appeared late 2021, we collected daily number cases Baidu Search Index (BSI) seven terms from 1 January to 30 April, 2022 12 provinces/prefectures explore variation China. Two peaks "COVID-19 epidemic", "Novel Coronavirus" "COVID-19" can be observed. One January, which showed 3 days Henan Tianjin. Another on early March, occurred 0-28 ahead local epidemic but had spatial variation. It 4 weeks Shanghai, 2 5-8 Jilin Province, Changchun Prefecture. But it only 1-3 Tianjin, Quanzhou Prefecture, Fujian Province 0 day Shenzhen, Shandong Qingdao Yanbian The BSI high correlated (rs:0.70-0.93) consistent epidemiological trend. temporal close related strength case detection ability should strengthened when perceiving increase.

Language: Английский

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