Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy DOI Creative Commons
Fei Xing, Ning Liu, Can Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

Abstract Colorectal cancer ranks as the third most prevalent form of globally, with chemotherapy remaining primary treatment modality. To mitigate drug resistance and minimize adverse effects associated chemotherapy, selection appropriate adjuvants assumes paramount importance. Caffeic acid phenyl ethyl(CAPE), a naturally occurring compound derived from propolis, exhibits diverse array biological activities. We observed that addition CAPE significantly augmented sensitivity colorectal cells to oxaliplatin. In SW480 HCT116 cells, oxaliplatin combined 10 µM reduced IC50 12 80 2 4 µM, respectively. then used proteomics detect differentially expressed proteins in CAPE-treated found main showing changes expression after were SQSTM1 (p62) MAP1LC3B (LC3B). Gene ontology analysis revealed exerted antitumor chemotherapy-sensitization through autophagy pathway. subsequently verified using immunoblotting. Simultaneously, inhibitor bafilomycin A1 an mCherry-EGFP-LC3 reporter gene controls effect on levels. Collectively, results indicate may exert chemotherapy-sensitizing by inhibiting autophagy, offering novel insights for development potential chemosensitizing agents.

Language: Английский

Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review DOI Creative Commons
Xuan Meng,

Yongli Shen,

Huanyu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 28, 2024

Language: Английский

Citations

15
Glutathione-scavenging natural-derived ferroptotic nano-amplifiers strengthen tumor therapy through aggravating iron overload and lipid peroxidation DOI

Ruie Chen,

Liewei Wen, Feng Guo

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 866 - 878

Published: Jan. 29, 2025

Language: Английский

Citations

1
The Role of Nrf2 in the Regulation of Mitochondrial Function and Ferroptosis in Pancreatic Cancer DOI Creative Commons

Dinara Baiskhanova,

H. Schäfer

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 696 - 696

Published: June 6, 2024

The transcription factor nuclear erythroid 2-related 2 (Nrf2) represents the master regulator of cellular antioxidant response and plays a critical role in tumorigenesis. This includes preventive effect Nrf2 on cell death through ferroptosis, which an essential mechanism therapy resistance malignant tumors, such as pancreatic ductal adenocarcinoma (PDAC) one most aggressive still incurable tumors. Addressing this issue, we provide overview mediated with particular emphasis its mitochondria organelle responsible for execution ferroptosis. We further outline how deregulated adds to progression PDAC, especially respect ferroptosis anti-cancer drug killing is impaired by resistance. Our review discusses recent approaches inhibition natural synthetic compounds overcome based enhanced Finally, outlook therapeutic strategies combined inducing drugs.

Language: Английский

Citations

5
Ferroptosis: a new mechanism of traditional Chinese medicine for cancer treatment DOI Creative Commons
Jiahao Zhu,

Peipei Shen,

Yu Xu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 16, 2024

Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the build-up of lipid peroxidation and reactive oxygen species (ROS) derived lipids within cells. Recent studies demonstrated efficacy ferroptosis inducers in targeting malignant cells, thereby establishing promising avenue for combating cancer. Traditional Chinese medicine (TCM) has long history use widely used cancer treatment. TCM takes holistic approach, viewing patient as system utilizing herbal formulas to address complex diseases such have elucidated molecular mechanisms underlying induction during These identified numerous plant metabolites derivatives that target multiple pathways targets. can induce tumor cells through various regulatory mechanisms, amino acid, iron, metabolism pathways, which may provide therapeutic strategies apoptosis-resistant also influence anticancer immunotherapy via ferroptosis. This review comprehensively elucidates ferroptosis, highlights pivotal genes involved orchestrating this process, evaluates advancements made research pertaining provides theoretical insights into tumors using botanical drugs.

Language: Английский

Citations

4
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

Citations

0
Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy DOI Creative Commons
Fei Xing, Ning Liu, Can Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 25, 2024

Abstract Colon cancer ranks as the third most prevalent form of globally, with chemotherapy remaining primary treatment modality. To mitigate drug resistance and minimize adverse effects associated chemotherapy, selection appropriate adjuvants assumes paramount importance. Caffeic acid phenethyl ester (CAPE), a naturally occurring compound derived from propolis, exhibits diverse array biological activities. We observed that addition CAPE significantly augmented sensitivity colon cells to oxaliplatin. In SW480 HCT116 cells, oxaliplatin combined 10 µM reduced IC 50 14.24 ± 1.03 84.16 3.02 2.11 0.15 3.92 0.17 µM, respectively. then used proteomics detect differentially expressed proteins in CAPE-treated found main showing changes expression after were p62 (SQSTM1) LC3B (MAP1LC3B). Gene ontology analysis revealed exerted antitumor chemotherapy-sensitization through autophagy pathway. subsequently verified using immunoblotting. Simultaneously, inhibitor bafilomycin A1 mCherry-EGFP-LC3 reporter gene controls effect on levels. Collectively, results indicate may exert chemotherapy-sensitizing by inhibiting autophagy, offering novel insights for development potential chemosensitizing agents.

Language: Английский

Citations

3
The mechanism by which piR-000699 targets SLC39A14 regulates ferroptosis in aging myocardial <?A3B2 pi6?>ischemia/reperfusion injury DOI Creative Commons

Hongyang Chi,

Yue’e Chai,

Lingju Ma

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: 56(9), P. 1352 - 1364

Published: Feb. 29, 2024

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by to cardiomyocytes leading different types cell death. The degree irreversible myocardial damage closely related age, and ferroptosis involved in cardiomyocyte damage. However, the mechanisms underlying regulation aging I/R are still unclear. present study aims explore mechanism piRNA ferroptosis. Using left anterior descending coronary artery ligation an rat model D-galactose-induced line (H9C2) construct model, we investigate whether occurs after reperfusion

Language: Английский

Citations

1
Targeting Disulfidptosis with Potentially Bioactive Natural Products in Metabolic Cancer Therapy DOI Creative Commons

Xinyan Li,

Jiayi Xu,

Liangwen Yan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 604 - 604

Published: Nov. 8, 2024

Metabolic cancers are defined by metabolic reprogramming. Although this reprograming drives rapid tumour growth and invasion, it also reveals specific vulnerabilities that can be therapeutically exploited in cancer therapy. A novel form of programmed cell death, known as disulfidptosis, was identified last year; cells with high SLC7A11 expression undergo disulfidptosis when deprived glucose. Natural products have attracted increasing attention shown potential to treat through diverse mechanisms.

Language: Английский

Citations

1
Research progress of iron metabolism and ferroptosis in myeloid neoplasms DOI
Yudi Wang, Weiying Feng, Fudi Wang

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Dysregulation of iron metabolism is present in a variety myeloid neoplasms. The prognosis acute leukemia related to the differential expression molecules. myelodysplastic syndrome patients with overload poor. Myeloproliferative neoplasms are often characterized by coexistence deficiency and erythrocytosis, which can be treated targeting hepcidin. Myeloid tumor cells susceptible oxidative damage caused accumulation reactive oxygen species sensitive ferroptosis. Ferroptosis has anti-tumor effect syndrome. Targeting ferroptosis reverse imatinib resistance chronic leukemia. All above research results indicate that affect development progression used as their therapeutic targets. This article reviews characteristics neoplasms, well mechanism ferroptosis, order provide basis for new strategies.

Language: Английский

Citations

0
Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy DOI Creative Commons
Fei Xing, Ning Liu, Can Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

Abstract Colorectal cancer ranks as the third most prevalent form of globally, with chemotherapy remaining primary treatment modality. To mitigate drug resistance and minimize adverse effects associated chemotherapy, selection appropriate adjuvants assumes paramount importance. Caffeic acid phenyl ethyl(CAPE), a naturally occurring compound derived from propolis, exhibits diverse array biological activities. We observed that addition CAPE significantly augmented sensitivity colorectal cells to oxaliplatin. In SW480 HCT116 cells, oxaliplatin combined 10 µM reduced IC50 12 80 2 4 µM, respectively. then used proteomics detect differentially expressed proteins in CAPE-treated found main showing changes expression after were SQSTM1 (p62) MAP1LC3B (LC3B). Gene ontology analysis revealed exerted antitumor chemotherapy-sensitization through autophagy pathway. subsequently verified using immunoblotting. Simultaneously, inhibitor bafilomycin A1 an mCherry-EGFP-LC3 reporter gene controls effect on levels. Collectively, results indicate may exert chemotherapy-sensitizing by inhibiting autophagy, offering novel insights for development potential chemosensitizing agents.

Language: Английский

Citations

0