Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng DOI Creative Commons
Ke Xu,

Biwen Hu,

Xuhui Ding

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(14), P. 6749 - 6756

Published: June 21, 2023

To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury. This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded tissue sections were prepared, later, BAX/BCL-2 protein expression was observed HE, Sirius red, TUNEL immunofluorescence detect apoptotic injury α-SMA/TGF-β fibrosis, inflammation-related NF-KB detected. HE staining showed that reduced necrotic cells fibrosis in liver-injured mice, increased anti-inflammatory cytokine IL-18 TNF-α, IL-1β IL-6 expression. Conclusion: Ginsenoside can effectively antagonize D-gal's role injury, its may be associated with regulating inflammatory Rg.

Language: Английский

Evaluating the effects of mitochondrial autophagy flux on ginsenoside Rg2 for delaying D-galactose induced brain aging in mice DOI
Junjie Zhang,

Ke‐cheng Chen,

Yue Zhou

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 104, P. 154341 - 154341

Published: July 16, 2022

Language: Английский

Citations

39
The anti-aging mechanism of ginsenosides with medicine and food homology DOI
Tiantian Tian,

Chung-Nga Ko,

Wenya Luo

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(20), P. 9123 - 9136

Published: Jan. 1, 2023

Ginsenosides resist the aging by regulating multiple signaling pathways.

Language: Английский

Citations

23
Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells DOI
Huimin Zhou, Yan Liu, Yong Su

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117794 - 117794

Published: Jan. 19, 2024

Language: Английский

Citations

12
Potential benefits of ginseng against COVID-19 by targeting inflammasomes DOI Creative Commons
Young‐Su Yi

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 46(6), P. 722 - 730

Published: April 5, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs system multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes inflammasome-mediated inflammatory signaling pathways, are key determinants of hyperinflammation storm in COVID-19 patients. Additionally, inhibits inflammasome activation to evade host's antiviral immunity. Therefore, regulating initiation has received increasing attention as a preventive measure Ginseng its active constituents, ginsenosides saponins, improve immune exert anti-inflammatory effects by targeting stimulation. this review discussed potential therapeutic roles ginseng based on regulatory role

Language: Английский

Citations

36
The NLRP3 inflammasome in fibrosis and aging: The known unknowns DOI

Yanqing Liu,

Xuezeng Xu,

Wangrui Lei

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 79, P. 101638 - 101638

Published: May 5, 2022

Language: Английский

Citations

32
Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice DOI Open Access
Duoduo Zhang,

Pengmin Ji,

Ran Sun

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112936 - 112936

Published: April 11, 2022

Chronic renal injury (CRI) is a common pathological damage in chronic disease, and the therapeutic options for preventing its progression are limited at present. Ginsenoside Rg1 (Rg1) reported to have protective effect on by improving oxidative stress inflammation. Lipopolysaccharide (LPS) plays important roles inducing inflammatory high-dose LPS often used perform acute injury. However, little known about of low-dose CRI, against LPS-induced CRI. Here, we mechanism CRI mice. In this study, results demonstrated that (0.25 mg/kg) exposure 14 days significantly induced function impairment fibrosis. Meanwhile, increased reactive oxygen species (ROS) generation, NADPH oxidase 4 (NOX4) NLRP3 inflammasome expression cortex. treatment with Rg1, tempol (a superoxide dismutase mimetic), apocynin NOX inhibitor) improved fibrosis, decreased levels TGF-β, IL-1β, KIM-1, β-Gal, collagen IV kidneys. And also reduced ROS generation inhibited activation NOX4 inflammasome. Overall, these suggest can ameliorate kidney mechanisms may be involved reducing NOX2-mediated inhibiting NLRP1

Language: Английский

Citations

28
Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources DOI Creative Commons
Lili Song, Shicui Zhang

Biomolecules, Journal Year: 2023, Volume and Issue: 13(11), P. 1600 - 1600

Published: Oct. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Language: Английский

Citations

20
Chinese herbal formula ruangan granule enhances the efficacy of entecavir to reverse advanced liver fibrosis/early cirrhosis in patients with chronic HBV infection: A multicenter, randomized clinical trial DOI Creative Commons
Yufeng Xing,

Weichao Zhong,

Deti Peng

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106737 - 106737

Published: March 20, 2023

Nucleotide analogs treatment can reverse liver fibrosis in chronic hepatitis B (CHB). However, it has limited effect on resolution patients with CHB, particularly preventing progression to hepatocellular carcinoma (HCC). Ruangan granule (RG), a Chinese herbal formula, proven produce therapeutic against animal experiment. Thus, we aimed evaluate the of our formula (RG) combined entecavir (ETV) advanced fibrosis/early cirrhosis from CHB. A total 240 CHB histologically confirmed 12 centers were randomly and blindly allocated consume either ETV (0.5 mg/day) plus RG (2 times/day) or control for 48 weeks (wk) treatment. Changes histopathology, serology imageology observed. Liver reversion, defined as reduction Knodell HAI score by ≥ 2 points Ishak 1 grade, was assessed. The rate regression inflammation remission after wk histopathology significantly higher + group (38.73% vs. 23.94%, P = 0.031). ultrasonic semiquantitative scores decreased 41 (28.87%) 15 (21.13%) ETV+RG groups, respectively (P 0.026). had lower Fibrosis-4 (FIB-4) index 0.028). There significant difference between groups function normalization < 0.01). Moreover, combination further reduced risk HCC median 55-month follow-up This study illustrates that improve reducing HCC.

Language: Английский

Citations

16
Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice DOI Creative Commons

Pengmin Ji,

Qifeng Shi,

Yan Liu

et al.

Renal Failure, Journal Year: 2023, Volume and Issue: 45(1)

Published: April 5, 2023

Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but mechanism unclear. NADPH oxidase 4 (NOX4) an essential reactive oxygen species (ROS) source in kidney. The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. Therefore, we hypothesized that might alleviate injury fibrosis by inhibiting NOX4 MAPK T2DM-induced DKD. We found significantly improves lipid deposition, fibrosis, ROS production reduces NOX4, p22phox, p47phox, p-ERK, p-JNK, p-P38 expressions T2DM mice kidneys. also high-fat diet palmitate (PA) PA + HG (high glucose) exposure human mesangial cells could induce production, activation NOX4-MAPK signaling. results suggest high glucose play significant role progression, while attenuate

Language: Английский

Citations

14
Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis DOI Creative Commons
Sixia Yang, Tingting Pei, Linshuang Wang

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 8039 - 8039

Published: Nov. 19, 2022

Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) considered have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related remain unclear. The study aimed evaluate protective effects SAMP8 mice. mice were administered Ferrostatin-1 (Fer-1) for 12 weeks. function, fibrosis, ferroptosis tissue detected. results showed that elevated blood urea nitrogen (BUN) serum creatinine (SCr) levels significantly decreased, albumin (ALB) increased, mesangial hyperplasia reduced group. transforming growth factor-β (TGF-β) α-smooth muscle actin (α-sma) treatment decreased lipid peroxidation kidneys, regulated iron transport-related proteins ferroptosis-related proteins. These suggested delays aging inhibits glomerular by inhibiting

Language: Английский

Citations

19