Validation of biomarkers of food intake—critical assessment of candidate biomarkers DOI Creative Commons
Lars Ove Dragsted, Qian Gao,

A. Scalbert

et al.

Genes & Nutrition, Journal Year: 2018, Volume and Issue: 13(1)

Published: May 30, 2018

Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments used. They may also be used to assess compliance guidelines or intervention. therefore hold promise direct and objective measurement intake. However, the number comprehensively validated biomarkers is limited just few. Many new candidate emerge from metabolic profiling studies advances chemistry. Furthermore, identified based on extensive literature reviews such as described Biomarker Food Intake Reviews (BFIRev). To systematically critically validity intake, it necessary outline streamline an optimal reproducible validation process. A consensus-based procedure was provide evaluate set most important criteria systematic BFIs. As result, developed including eight criteria, plausibility, dose-response, time-response, robustness, reliability, stability, analytical performance, inter-laboratory reproducibility. The has dual purpose: (1) estimate current level approach (2) pinpoint which additional needed full each biomarker This position paper outlines second step BFIRev but identified, e.g., metabolomic studies.

Language: Английский

Metabolomics: beyond biomarkers and towards mechanisms DOI
Caroline H. Johnson, Julijana Ivanišević, Gary Siuzdak

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2016, Volume and Issue: 17(7), P. 451 - 459

Published: March 16, 2016

Language: Английский

Citations

2192
Emerging applications of metabolomics in drug discovery and precision medicine DOI
David S. Wishart

Nature Reviews Drug Discovery, Journal Year: 2016, Volume and Issue: 15(7), P. 473 - 484

Published: March 11, 2016

Language: Английский

Citations

1265
Metabolomics for Investigating Physiological and Pathophysiological Processes DOI Open Access
David S. Wishart

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1819 - 1875

Published: Aug. 22, 2019

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in metabolomics is leading a renewed interest metabolism and role that small molecule play many biological processes. As result, traditional views as being simply “bricks mortar” cells just fuel for cellular energetics are upended. Indeed, appear have much more varied far important roles signaling molecules, immune modulators, endogenous toxins, environmental sensors. This review explores how yielding new insights into number physiological In particular, major focus on illustrating discoveries made through improving our understanding both normal physiology pathophysiology diseases. These influence organ function, nutrient sensing, gut physiology. Collectively, this work unified system-wide perspective biology wherein metabolites, proteins, genes understood interact synergistically modify actions functions organelles, organisms.

Language: Английский

Citations

795
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update DOI
Ana Rodriguez‐Mateos, David Vauzour, Christian G. Krueger

et al.

Archives of Toxicology, Journal Year: 2014, Volume and Issue: 88(10), P. 1803 - 1853

Published: Sept. 2, 2014

Language: Английский

Citations

550
The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective DOI Creative Commons
Gary Williamson, Colin D. Kay, Alan Crozier

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2018, Volume and Issue: 17(5), P. 1054 - 1112

Published: July 10, 2018

Abstract Flavonoids are plant‐derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and complex pathways involved bioavailability of flavonoids body now well understood. In recent years, been appreciated that gut microbiome plays major role flavonoid action, but much progress still needs to be made this area. Since first publications health effects flavonoids, their action is understood protect against various stresses, mechanism evolved from debunked simple direct antioxidant hypothesis into an understanding molecular targets enzymes specific cell types. This review traces development field over past 8 decades, indicates current state art, how was reached. Future recommendations based historical analysis (a) focus key areas (b) perform intervention studies focusing protective effects, (c) carry out cellular vitro experiments using appropriate cells together chemical form found at site action; could native compounds food for digestion intestine, conjugated metabolites blood after absorption small intestine cells, or forms tissues catabolism by microbiota.

Language: Английский

Citations

475
Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies DOI Creative Commons
Yoriko Heianza, Wenjie Ma, JoAnn E. Manson

et al.

Journal of the American Heart Association, Journal Year: 2017, Volume and Issue: 6(7)

Published: June 30, 2017

Gut microbial metabolites have been implicated as novel risk factors for cardiovascular events and premature death. The strength consistency of associations between blood concentrations the gut metabolites, trimethylamine-N-oxide (TMAO) its precursors, with major adverse (MACE) or death not comprehensively assessed. We quantified TMAO precursors risks MACE mortality.PubMed Embase databases were searched up, a total 19 prospective studies from 16 publications (n=19 256, including 3315 incident cases) quantitative estimates development included in our main analysis. Multivariate-adjusted relative (RRs) used when these available. Elevated associated pooled RR 1.62 (95% CI, 1.45, 1.80; Pheterogeneity=0.2; I2=23.5%) compared low levels, 1 study black participants influenced heterogeneity association. After excluding data blacks, RRs different according to body mass index, prevalence diabetes mellitus, history diseases, kidney dysfunction. Furthermore, elevated 1.63 (1.36, 1.95) all-cause mortality. Individuals (l-carnitine, choline, betaine) had an approximately 1.3 1.4 times higher those concentrations.Elevated increased mortality independently traditional factors.

Language: Английский

Citations

454
Review of recent developments in GC–MS approaches to metabolomics-based research DOI
David J. Beale, Farhana R. Pinu, Konstantinos A. Kouremenos

et al.

Metabolomics, Journal Year: 2018, Volume and Issue: 14(11)

Published: Nov. 1, 2018

Language: Английский

Citations

420
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial DOI

Keith McIntosh,

David E. Reed,

Theresa Schneider

et al.

Gut, Journal Year: 2016, Volume and Issue: 66(7), P. 1241 - 1251

Published: March 14, 2016

Objective To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides polyols (FODMAP) high FODMAP diets on symptoms, the metabolome microbiome patients with IBS. Design We performed a controlled, single blind study IBS (Rome III criteria) randomised to (n=20) or diet for 3 weeks. Symptoms were assessed using symptom severity scoring (IBS-SSS). The was evaluated lactulose breath test (LBT) metabolic profiling in urine mass spectrometry. Stool microbiota composition analysed by 16S rRNA gene profiling. Results Thirty-seven (19 FODMAP; 18 FODMAP) completed 3-week diet. IBS-SSS reduced group (p<0.001) but not group. LBTs showed minor decrease H 2 production Metabolic groups differed significantly after (p<0.01), three metabolites (histamine, p-hydroxybenzoic acid, azelaic acid) being primarily responsible discrimination between two groups. Histamine, measure immune activation, eightfold (p<0.05). Low increased Actinobacteria richness diversity, decreased relative abundance bacteria involved gas consumption. Conclusions symptoms are linked content associated alterations metabolome. In subsets patients, FODMAPs modulate histamine levels microbiota, both which could alter symptoms. Trial registration number NCT01829932.

Language: Английский

Citations

414
Intestinal Microbiota in Cardiovascular Health and Disease DOI
W.H. Wilson Tang, Fredrik Bäckhed, Ulf Landmesser

et al.

Journal of the American College of Cardiology, Journal Year: 2019, Volume and Issue: 73(16), P. 2089 - 2105

Published: April 1, 2019

Language: Английский

Citations

390
The Blood Exposome and Its Role in Discovering Causes of Disease DOI Creative Commons
Stephen M. Rappaport, Dinesh Kumar Barupal, David S. Wishart

et al.

Environmental Health Perspectives, Journal Year: 2014, Volume and Issue: 122(8), P. 769 - 774

Published: March 21, 2014

Since 2001, researchers have examined the human genome (G) mainly to discover causes of disease, despite evidence that G explains relatively little risk. We posit unexplained disease risks are caused by exposome (E; representing all exposures) and × E interactions. Thus, etiologic research has been hampered scientists' continuing reliance on low-tech methods characterize compared with high-tech omics for characterizing G.

Language: Английский

Citations

346