Curcumin, the golden spice in treating cardiovascular diseases

Biotechnology Advances, Journal Year: 2019, Volume and Issue: 38, P. 107343 - 107343

Published: Feb. 1, 2019

Language: Английский

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Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Neuroscience, Journal Year: 2019, Volume and Issue: 406, P. 1 - 21

Published: Feb. 28, 2019

Language: Английский

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Curcumin, Gut Microbiota, and Neuroprotection

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2426 - 2426

Published: Oct. 11, 2019

Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. However, discrepancy exists between well-documented pharmacological activities that curcumin seems to possess in vivo its poor aqueous solubility, bioavailability, pharmacokinetic profiles should limit any therapeutic effect. Thus, it is possible could exert direct regulative effects primarily gastrointestinal tract, where high concentrations are present after oral administration. Indeed, new working hypothesis explain neuroprotective role despite limited availability acts indirectly on central nervous system by influencing "microbiota-gut-brain axis", complex bidirectional which microbiome composition represent factor preserves determines brain "health". Interestingly, metabolites might provide benefit restoring dysbiosis gut microbiome. Conversely, subject bacterial enzymatic modifications, forming pharmacologically more active than curcumin. These mutual interactions allow keep proper individual physiologic functions play key neuroprotection.

Language: Английский

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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111888 - 111888

Published: July 5, 2021

Curcumin, isolated from Curcuma longa L., is a fat-soluble natural compound that can be obtained ginger plant tuber roots, which accumulative evidences have demonstrated it resist viral and microbial infection has anti-tumor, reduction of blood lipid glucose, antioxidant removal free radicals, active against numerous disorders various chronic diseases including cardiovascular, pulmonary, neurological autoimmune diseases. In this article highlighted the recent evidence curcuminoids applied in sevral aspects medical problem particular COVID-19 pandemics. We searched several literature databases MEDLINE (PubMed), EMBASE, Web Science, Cochrane Library, Google Scholar, ClinicalTrials.gov website via using curcumin medicinal properties as keyword. All studies published time when database was established to May 2021 retrieved. This review summarizes growing confirmation for mechanisms related curcumin's physiological pharmacological effects with target proteins interaction molecular docking. The purpose provide deeper insight understandings value discovery development new drugs. Curcumin could used prevention or therapy cardiovascular disease, respiratory diseases, cancer, neurodegeneration, infection, inflammation based on cellular biochemical, regulation, suppression immunomodulation.

Language: Английский

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Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Journal of Orthopaedic Surgery and Research, Journal Year: 2019, Volume and Issue: 14(1)

Published: Sept. 11, 2019

Abstract Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that mainly featured by stiffness and cartilage degradation. Icariin (ICA), an extract from Epimedium , has been preliminarily proven to show anti-osteoporotic anti-inflammatory effects in OA. However, underlying mechanisms of ICA on chondrocytes need be elucidated. Methods LPS-treated monosodium iodoacetate (MIA)-treated Wistar rats were used as models OA vitro vivo, respectively. LDH MTT assays performed detect cytotoxicity cell viability. The expression levels NLRP3, IL-1β, IL-18, MMP-1, MMP-13, collagen II detected qRT-PCR Western blotting. release IL-1β IL-18 ELISA assay. Caspase-1 activity was assessed flow cytometry. Immunofluorescence immunohistochemistry examine level NLRP3 rat cartilage, progression monitored with hematoxylin-eosin (H&E) staining safranin O/fast green staining. Results could suppress LPS-induced inflammation reduction formation chondrocytes. Furthermore, inhibit inflammasome-mediated caspase-1 signaling pathway alleviate pyroptosis induced LPS. Overexpression reversed above changes caused ICA. It further confirmed model alleviated inhibiting NLRP3-mediated pyroptosis. Conclusion inhibited via repressing NLRP3/caspase-1 signaling-mediated suggesting might a promising compound treatment

Language: Английский

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A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Chemosphere, Journal Year: 2021, Volume and Issue: 271, P. 129499 - 129499

Published: Jan. 4, 2021

Language: Английский

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Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer’s disease

Bioorganic Chemistry, Journal Year: 2021, Volume and Issue: 108, P. 104681 - 104681

Published: Jan. 29, 2021

Language: Английский

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Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Molecules, Journal Year: 2021, Volume and Issue: 26(17), P. 5327 - 5327

Published: Sept. 2, 2021

Natural products derived from plants, as well their bioactive compounds, have been extensively studied in recent years for therapeutic potential a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These are characterized by progressive dysfunction loss neuronal structure function. There has little progress designing efficient treatments, despite impressive breakthroughs our understanding NDs. In the prevention therapy NDs, use natural may provide great opportunities; however, many clinical issues emerged regarding use, primarily based on lack scientific support or proof effectiveness patient safety. Since neurodegeneration is associated with myriad pathological processes, targeting multi-mechanisms action neuroprotection approaches that include preventing cell death restoring function damaged neurons should be employed. treatment AD PD, neuroprotective agents. This current review will highlight numerous compounds thatexert effects pathologies

Language: Английский

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Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2140 - 2140

Published: June 22, 2022

Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to World Health Organization (WHO), neurological main causes mortality worldwide. include Alzheimer’s disease, Parkinson′s Huntington′s Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion Brain tumor, Spinal cord injury, and Stroke. These diseases considered incurable because no specific therapies available cross blood-brain barrier (BBB) reach brain in a significant amount for pharmacological effect brain. There is need development strategies that can improve efficacy drugs circumvent BBB. One promising approaches use different types nano-scale materials. nano-based have ability increase therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, drug loading capacity. Different shapes nanomaterials been widely used treatment disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. nanoparticles unique characteristics, sensitivity, selectivity, BBB when nano-sized particles, imaging studies NDs. In this review, we briefly summarized recent literature on various their mechanism action disorders.

Language: Английский

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Longevity and anti-aging effects of curcumin supplementation

GeroScience, Journal Year: 2024, Volume and Issue: 46(3), P. 2933 - 2950

Published: Feb. 27, 2024

Language: Английский

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