Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

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Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102664 - 102664

Published: Jan. 1, 2025

Language: Английский

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The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10757 - 10757

Published: Oct. 6, 2024

With the aging of global population, neurodegenerative diseases are emerging as a major public health issue. The adoption less sedentary lifestyle has been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key hallmarks, such genomic instability, telomere attrition, neuroinflammation, underscore need for comprehensive personalized strategies promote resilience healthy aging.

Language: Английский

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The Role of Astrocytes in the Temporoammonic Pathway: Masticatory Behavior as a Neuroprotective Strategy Against Age-Related Cognitive Decline

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Astrocytes undergo phenotypic changes with aging, contributing to neurodegenerative diseases and cognitive impairments in later life. The temporoammonic (TA) pathway terminates at the stratum lacunosum-moleculare (SLM) of CA1 region, where astrocytic support is crucial for synaptic plasticity information processing related spatial learning memory. This study tested hypothesis that age-related morphological astrocytes SLM affect performance we explored whether masticatory activity modulates these changes. Young (6 months) aged (18 female Swiss albino mice were subjected three distinct regimens: a hard diet (HD), HD followed by soft (HD/SD), or SD return (HD/SD/HD). Cognitive was assessed using Morris Water Maze (MWM), rates calculated from escape latencies throughout five days trials. After behavioral testing, culled immunohistochemical analysis glial fibrillary acidic protein (GFAP) expression performed. 3D reconstructions within generated analyzed. Hierarchical clustering identified astrocyte morphotypes, revealing significant shift high-complexity (AST1) toward lower-complexity subtypes (AST2 AST3. results demonstrate aging reduces complexity, especially dorsal which correlated impaired Notably, on HD/SD/HD regimen exhibited partial recovery function morphology, suggesting potential rehabilitation effect activity. Statistical confirmed differences complexity across age groups dietary regimens (p < 0.01). These findings highlight may contribute decline. Overall, maintaining proper mastication be an effective approach maintain integrity during preserve hippocampus-dependent function, particularly older individuals.

Language: Английский

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Research Progress of Bile Acids in Neurodegenerative Diseases

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

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AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100142 - 100142

Published: March 1, 2025

Language: Английский

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Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(15)

Published: April 17, 2025

Parkinson's disease (PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction. The exploration of novel therapeutic strategies for PD is vital. To investigate the potential mechanism action rhapontin-a natural compound with known antioxidant anti-inflammatory properties-in context PD. Network pharmacology was used to predict targets mechanisms rhapontin in Behavioral tests tyrosine hydroxylase immunofluorescence analysis were assess effect on symptoms pathology MPTP-induced mice. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, IL-10 levels tissues measured using an enzyme-linked immunosorbent assay (ELISA). Additionally, nuclear erythroid 2-related 2 (NRF2) activation confirmed western blotting. NRF2 predicted be key transcription underlying effects PD, its anti-PD may associated properties. Rhapontin ameliorated loss dopaminergic neurons dysfunction 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice activating NRF2. treatment significantly decreased pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) substantia nigra, striatum, colon, whereas it increased cytokine (IL-10) only indicating involvement gut-brain axis neuroprotective potential. Finally, identified as a activated rhapontin, particularly colon. We elucidated mouse models combination network analysis, behavioral assessments, immunofluorescence, ELISA, Western Our findings revealed multifaceted role ameliorating through properties, NRF2, paving way future research into targeted therapies

Language: Английский

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Gut microbiota and ovarian diseases: a new therapeutic perspective

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: May 21, 2025

The gut microbiota is a complex community of microorganisms that inhabit the human gastrointestinal tract, helping to maintain ecological balance body's internal and external environments. Disruptions in composition diversity microbiota, as well changes their metabolic functions, can link development severity conditions such premature ovarian insufficiency, polycystic ovary syndrome, tumors. This article thoroughly reviews recent research on connection between diseases, providing fresh perspectives prevention, pathogenesis, treatment.

Language: Английский

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Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

The human body contains approximately 100 trillion microorganisms, predominantly within the gastrointestinal tract, collectively called gut microbiota. Investigations have revealed bidirectional communication between microbiota and brain, characterized as "microbiota-gut-brain axis." This axis represents an important regulator of brain development function, immune system development, nutrient metabolism, making it a target for efforts to alleviate progression neurodegenerative diseases (NDDs). Despite extensive biomedical clinical research, our understanding causes, optimal treatment, NDDs remains limited. paper aims summarize available knowledge on role played by how is connected conditions; in particular, relationship gut-brain communications neuro-immune conditions reviewed. We discuss why communicates with this impacts neurodegeneration. Next, we examine alterations microbiota, response, changes associated dysbiosis. Finally, highlight preclinical evidence probiotics, prebiotics, fecal transplantation, dietary supplements, natural drugs, exercise intervention potential therapeutic approaches that could lead new treatment paradigm NDDs.

Language: Английский

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In vivo mechanism of interaction between trimethylamine lyase expresssion and glycolytic pathways

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Inhibition of key enzymes by glycolysis inhibitors could promote the utilization and conversion glycine, thereby reducing synthesis trimethylamine lyase.

Language: Английский

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