Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 23, 2024

Placental function plays a crucial role in fetal development, as it serves the primary interface for delivery of nutrients and oxygen from mother to fetus. Magnetic resonance imaging (MRI) has significantly improved our ability visualize understand placenta's complex structure function. This review provides an up-to-date examination most common novel placental MRI techniques. It will also discuss clinical applications diagnosing monitoring insufficiency, well its implications growth restriction (FGR) congenital heart disease (CHD). Ongoing research using multi-parametric techniques aims develop biomarkers uncover relationships between parameters pre-onset diseased states, ultimately contributing better maternal health outcomes, which is essential guide judgement.

Language: Английский

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Validation of a Food Knowledge Questionnaire on Tanzanian Women of Childbearing Age

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 691 - 691

Published: Feb. 7, 2022

The present manuscript describes the validation of a food knowledge questionnaire (FKQ) for Tanzanian childbearing age women. FKQ was derived from Ugandan version and adapted according to culture habits, including 114 closed-ended questions, divided into five different sections. administered 671 childbearing-age women who were eligible if they: (i) aged between 14 49 years old, (ii) had not been diagnosed with any disease (iii) lived in urban or peri-urban area Arusha Morogoro region. process conducted Tanzania recruitment occurred August October 2020. final validated characterized by total 88 ten sections; each section aimed investigate aspect knowledge, except A, which collected information related social demographic characteristics respondent. showed good construct validity content assess practices could be used future studies identify at higher risk unhealthy eating habits choices.

Language: Английский

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Influence of adipose tissue immune dysfunction on childhood obesity

Cytokine & Growth Factor Reviews, Journal Year: 2022, Volume and Issue: 65, P. 27 - 38

Published: May 4, 2022

Language: Английский

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Serotonin and cyclic sleep organization in full-term newborn infants with intrauterine growth retardation

Journal of obstetrics and women s diseases, Journal Year: 2023, Volume and Issue: 71(6), P. 5 - 14

Published: Feb. 7, 2023

BACKGROUND: The high frequency of neurological and mental diseases in children who had intrauterine retardatiojn development indicates the need to study specific markers disorders fetal brain functional development, particular, state serotonergic system, which plays a key role morpho-functional early ontogenesis. AIM: To content serotonin full-term newborns with delay comparison quantitative qualitative characteristics sleep. MATERIALS AND MЕTHODS: main group consisted 26 newborns, whose took place conditions chronic placental insufficiency, led formation an asymmetric form development. control 72 healthy from mothers without pregnancy complications. Children each are divided into three subgroups depending on gestational age: I 37, II 38, III 3940 weeks. In all children, 712 hours after birth, electropoligram sleep was recorded (an electroencephalograph company Mizar, Russia) its analyses were carried out, highlighting orthodox, paradoxical phase undifferentiated state. determined platelet-rich plasma blood umbilical cord vein as well platelet suspension prepared venous taken first day life. platelets judged by indicator obtained dividing amount level. high-performance liquid chromatography electrochemical detection. Statistical analysis performed using Statistica 6 program (Statsoft Inc, USA). RESULTS: We report here low growth retardation absence normal increase weeks 3739 violation genetic programming for sleep-wake cycle organization. CONCLUSIONS: Assessment serotonin-producing system newborn pattern can serve diagnostic marker damage substantiate timely application neuroprotection.

Language: Английский

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Epigenetic influences and brain development

S S Korsakov Journal of Neurology and Psychiatry, Journal Year: 2023, Volume and Issue: 123(3), P. 12 - 12

Published: Jan. 1, 2023

In recent years, the amount of scientific data on involvement epigenetic processes in regulation brain development postnatal ontogenesis has been rapidly growing. The article provides an overview research mechanisms influences development. Information was searched Scopus, Web Science, MedLine, Cochrane Library, PubMed, Pedro, Scholar, eLibrary, CyberLeninka and RSCI databases for period 1940-2022 by keywords: development, epigenetics, neuroontogenesis, methylation, histone modifications, chromatin remodeling, non-coding RNAs. Today, influence genome include DNA RNA covalent modification histones, Epigenetic modifications are often reversible provide necessary plasticity response progenitor cells to environmental signals. each these factors neurodevelopment is considered. possibility transsynaptic transmission hereditary material means circular indicated. main ways microRNA presented their universality as «overgenic» regulator organism adaptation external conditions Data relationship long RNAs with functional activity oligodendroglia presented. Also, indicate paths pathogenetically determined prevention congenital pathology.В последние годы стремительно растет объем научных данных об участии эпигенетических процессов в регулировании развития головного мозга постнатальном онтогенезе. В статье приведен обзор исследований по механизмам влияний на развитие мозга. Выполнен поиск информации базах и РИНЦ за период 1940—2022 гг. ключевым словам «развитие мозга», «эпигенетика», «нейроонтогенез», «метилирование», «гистоновые модификации», «ремоделирование хроматина», «некодирующие РНК». К эпигенетического влияния геном относят метилирование ДНК РНК, ковалентную модификацию гистонов, ремоделирование хроматина, а также влияние некодирующих РНК. Эпигенетические модификации часто бывают обратимыми обеспечивают необходимую пластичность для ответа клеток-предшественников средовые сигналы. Рассмотрено каждого из этих факторов. Указано возможность транссинаптической передачи наследственного материала посредством кольцевых Приведены основные пути микроРНК указано их универсальность как надгенного регулятора адаптации организма к внешним условиям. данные о связи длинных РНК с регуляцией функциональной активности олигодендроглии. Представленные сведения свидетельствуют актуальности индивидуального подхода патогенезу нарушений мозга, перспективах патогенетически обусловленной профилактики врожденной патологии ЦНС.

Language: Русский

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